JPS5587777A - Pyrimidine derivative, its preparation and antitumorigenic agent - Google Patents

Pyrimidine derivative, its preparation and antitumorigenic agent

Info

Publication number
JPS5587777A
JPS5587777A JP15996278A JP15996278A JPS5587777A JP S5587777 A JPS5587777 A JP S5587777A JP 15996278 A JP15996278 A JP 15996278A JP 15996278 A JP15996278 A JP 15996278A JP S5587777 A JPS5587777 A JP S5587777A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
alkyl
pyrimidine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15996278A
Other languages
Japanese (ja)
Other versions
JPS6337787B2 (en
Inventor
Setsuo Fujii
Yoshinori Sakai
Yutaro Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP15996278A priority Critical patent/JPS5587777A/en
Publication of JPS5587777A publication Critical patent/JPS5587777A/en
Publication of JPS6337787B2 publication Critical patent/JPS6337787B2/ja
Granted legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Pyrimidine derivatives of formula I (R1 and R2 are H, Cl, Br, carboxyl, amide, 1W30C alkyl, 3W10C cycloalkyl, aryl, etc.; R3 and R4 are H, halogen, 1W30C alkyl, aryl, 1W30C aliphatic acyl, aroyl, etc.; where R3 is equal to R4 and both of them are not H).
EXAMPLE: N'-Butoxycarbonyluracil.
USE: They are used in combination with 5-fluorouracil, antitumorigenic agent. They also are used as synthetic intermediate of 5-fluorouracils. 0.01W10 moles of the compound of formula I are combined with 1mol of 5-fluorouracil.
PREPARATION: The condensation reaction of a compound of formula IV as uracil with a compound of formula II (Y is halogen; X is O, S, imino; R5 is alkyl, cycloalkyl, etc.) as n-butyl chlorocarbonate and a halide of formula III or Y-R5 is effected in an aprotonic organic solvent in the presence of a base to form the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP15996278A 1978-12-27 1978-12-27 Pyrimidine derivative, its preparation and antitumorigenic agent Granted JPS5587777A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15996278A JPS5587777A (en) 1978-12-27 1978-12-27 Pyrimidine derivative, its preparation and antitumorigenic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15996278A JPS5587777A (en) 1978-12-27 1978-12-27 Pyrimidine derivative, its preparation and antitumorigenic agent

Publications (2)

Publication Number Publication Date
JPS5587777A true JPS5587777A (en) 1980-07-02
JPS6337787B2 JPS6337787B2 (en) 1988-07-27

Family

ID=15704965

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15996278A Granted JPS5587777A (en) 1978-12-27 1978-12-27 Pyrimidine derivative, its preparation and antitumorigenic agent

Country Status (1)

Country Link
JP (1) JPS5587777A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60184066A (en) * 1984-03-02 1985-09-19 Sagami Chem Res Center 5-fluoro-6-chlorouracil derivative and its preparation
EP0877022A1 (en) * 1997-05-09 1998-11-11 Herbos d.d. Synthesis of the sulfonylpyrimidine derivatives with anticancer activity
US6410546B1 (en) 1997-04-07 2002-06-25 Triangle Pharmaceuticals, Inc. Use of MKC-442 in combination with other antiviral agents
USRE37979E1 (en) 1989-09-29 2003-02-04 Mitsubishi Chemical Corporation Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof
JP2003505451A (en) * 1999-07-22 2003-02-12 ブラッコ イメージング エッセ ピ ア Ceramide analogs, methods for their preparation and their use as antitumor agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6223723A (en) * 1985-07-24 1987-01-31 Canon Inc Process for injection and compression molding

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6223723A (en) * 1985-07-24 1987-01-31 Canon Inc Process for injection and compression molding

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60184066A (en) * 1984-03-02 1985-09-19 Sagami Chem Res Center 5-fluoro-6-chlorouracil derivative and its preparation
USRE37979E1 (en) 1989-09-29 2003-02-04 Mitsubishi Chemical Corporation Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof
US6410546B1 (en) 1997-04-07 2002-06-25 Triangle Pharmaceuticals, Inc. Use of MKC-442 in combination with other antiviral agents
EP0877022A1 (en) * 1997-05-09 1998-11-11 Herbos d.d. Synthesis of the sulfonylpyrimidine derivatives with anticancer activity
JP2003505451A (en) * 1999-07-22 2003-02-12 ブラッコ イメージング エッセ ピ ア Ceramide analogs, methods for their preparation and their use as antitumor agents
JP4652647B2 (en) * 1999-07-22 2011-03-16 ブラッコ イメージング エッセ ピ ア Ceramide analogues, methods for their preparation and their use as antitumor agents

Also Published As

Publication number Publication date
JPS6337787B2 (en) 1988-07-27

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