JPS5587777A - Pyrimidine derivative, its preparation and antitumorigenic agent - Google Patents
Pyrimidine derivative, its preparation and antitumorigenic agentInfo
- Publication number
- JPS5587777A JPS5587777A JP15996278A JP15996278A JPS5587777A JP S5587777 A JPS5587777 A JP S5587777A JP 15996278 A JP15996278 A JP 15996278A JP 15996278 A JP15996278 A JP 15996278A JP S5587777 A JPS5587777 A JP S5587777A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- alkyl
- pyrimidine derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Pyrimidine derivatives of formula I (R1 and R2 are H, Cl, Br, carboxyl, amide, 1W30C alkyl, 3W10C cycloalkyl, aryl, etc.; R3 and R4 are H, halogen, 1W30C alkyl, aryl, 1W30C aliphatic acyl, aroyl, etc.; where R3 is equal to R4 and both of them are not H).
EXAMPLE: N'-Butoxycarbonyluracil.
USE: They are used in combination with 5-fluorouracil, antitumorigenic agent. They also are used as synthetic intermediate of 5-fluorouracils. 0.01W10 moles of the compound of formula I are combined with 1mol of 5-fluorouracil.
PREPARATION: The condensation reaction of a compound of formula IV as uracil with a compound of formula II (Y is halogen; X is O, S, imino; R5 is alkyl, cycloalkyl, etc.) as n-butyl chlorocarbonate and a halide of formula III or Y-R5 is effected in an aprotonic organic solvent in the presence of a base to form the objective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15996278A JPS5587777A (en) | 1978-12-27 | 1978-12-27 | Pyrimidine derivative, its preparation and antitumorigenic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15996278A JPS5587777A (en) | 1978-12-27 | 1978-12-27 | Pyrimidine derivative, its preparation and antitumorigenic agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5587777A true JPS5587777A (en) | 1980-07-02 |
JPS6337787B2 JPS6337787B2 (en) | 1988-07-27 |
Family
ID=15704965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15996278A Granted JPS5587777A (en) | 1978-12-27 | 1978-12-27 | Pyrimidine derivative, its preparation and antitumorigenic agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5587777A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60184066A (en) * | 1984-03-02 | 1985-09-19 | Sagami Chem Res Center | 5-fluoro-6-chlorouracil derivative and its preparation |
EP0877022A1 (en) * | 1997-05-09 | 1998-11-11 | Herbos d.d. | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity |
US6410546B1 (en) | 1997-04-07 | 2002-06-25 | Triangle Pharmaceuticals, Inc. | Use of MKC-442 in combination with other antiviral agents |
USRE37979E1 (en) | 1989-09-29 | 2003-02-04 | Mitsubishi Chemical Corporation | Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof |
JP2003505451A (en) * | 1999-07-22 | 2003-02-12 | ブラッコ イメージング エッセ ピ ア | Ceramide analogs, methods for their preparation and their use as antitumor agents |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6223723A (en) * | 1985-07-24 | 1987-01-31 | Canon Inc | Process for injection and compression molding |
-
1978
- 1978-12-27 JP JP15996278A patent/JPS5587777A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6223723A (en) * | 1985-07-24 | 1987-01-31 | Canon Inc | Process for injection and compression molding |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60184066A (en) * | 1984-03-02 | 1985-09-19 | Sagami Chem Res Center | 5-fluoro-6-chlorouracil derivative and its preparation |
USRE37979E1 (en) | 1989-09-29 | 2003-02-04 | Mitsubishi Chemical Corporation | Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof |
US6410546B1 (en) | 1997-04-07 | 2002-06-25 | Triangle Pharmaceuticals, Inc. | Use of MKC-442 in combination with other antiviral agents |
EP0877022A1 (en) * | 1997-05-09 | 1998-11-11 | Herbos d.d. | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity |
JP2003505451A (en) * | 1999-07-22 | 2003-02-12 | ブラッコ イメージング エッセ ピ ア | Ceramide analogs, methods for their preparation and their use as antitumor agents |
JP4652647B2 (en) * | 1999-07-22 | 2011-03-16 | ブラッコ イメージング エッセ ピ ア | Ceramide analogues, methods for their preparation and their use as antitumor agents |
Also Published As
Publication number | Publication date |
---|---|
JPS6337787B2 (en) | 1988-07-27 |
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