JPS5581865A - 5-fluorouracil derivatives and their preparation - Google Patents
5-fluorouracil derivatives and their preparationInfo
- Publication number
- JPS5581865A JPS5581865A JP14098379A JP14098379A JPS5581865A JP S5581865 A JPS5581865 A JP S5581865A JP 14098379 A JP14098379 A JP 14098379A JP 14098379 A JP14098379 A JP 14098379A JP S5581865 A JPS5581865 A JP S5581865A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- fluorouracil
- preparation
- lower alkyl
- bridged ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:5-Fluorouracil derivatives of formula I (R is aliphatic hydrocarbyl with bridged ring, sustituted lower alkyl).
EXAMPLE: 1-[N-(1-adamantylmethyl)carbamoyl]5-fluorouracil.
USE: An antitumorigenic agent.
PREPARATION: 5-Fluorouracil of formula I is made to react with an isocyanate of formula III (Ra is aliphatic hydrocarbyl with bridged ring, substituted lower alkyl) in a solvent as benzene or DMSO, under anhydrous conditions at room temperature or with heat to produce the objective compound of formula Ia.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/111,643 US4349552A (en) | 1978-10-30 | 1980-01-14 | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7842426 | 1978-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5581865A true JPS5581865A (en) | 1980-06-20 |
Family
ID=10500686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14098379A Pending JPS5581865A (en) | 1978-10-30 | 1979-10-30 | 5-fluorouracil derivatives and their preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5581865A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5663966A (en) * | 1979-10-29 | 1981-05-30 | Tokyo Kinzoku Kogyo Kk | Pyrimidine derivative and its preparation |
JPS5785374A (en) * | 1980-11-18 | 1982-05-28 | Mitsui Toatsu Chem Inc | 5-fluorouracil derivative and its preparation |
JPS60181085A (en) * | 1984-02-28 | 1985-09-14 | Chisso Corp | 5-fluorouracil derivative |
JPS61204171A (en) * | 1985-03-06 | 1986-09-10 | Terumo Corp | 5-fluorouracil derivative and medicinal drug preparation containing same |
JP2000169371A (en) * | 1998-10-02 | 2000-06-20 | Sankyo Co Ltd | Medicament containing dithiolane derivative |
JP2017501120A (en) * | 2013-11-13 | 2017-01-12 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Methods for preparing inhibitors of influenza virus replication |
-
1979
- 1979-10-30 JP JP14098379A patent/JPS5581865A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5663966A (en) * | 1979-10-29 | 1981-05-30 | Tokyo Kinzoku Kogyo Kk | Pyrimidine derivative and its preparation |
JPS5785374A (en) * | 1980-11-18 | 1982-05-28 | Mitsui Toatsu Chem Inc | 5-fluorouracil derivative and its preparation |
JPS60181085A (en) * | 1984-02-28 | 1985-09-14 | Chisso Corp | 5-fluorouracil derivative |
JPS61204171A (en) * | 1985-03-06 | 1986-09-10 | Terumo Corp | 5-fluorouracil derivative and medicinal drug preparation containing same |
JPH0530833B2 (en) * | 1985-03-06 | 1993-05-11 | Terumo Corp | |
JP2000169371A (en) * | 1998-10-02 | 2000-06-20 | Sankyo Co Ltd | Medicament containing dithiolane derivative |
JP2017501120A (en) * | 2013-11-13 | 2017-01-12 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Methods for preparing inhibitors of influenza virus replication |
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