JPS5663966A - Pyrimidine derivative and its preparation - Google Patents

Pyrimidine derivative and its preparation

Info

Publication number
JPS5663966A
JPS5663966A JP13943079A JP13943079A JPS5663966A JP S5663966 A JPS5663966 A JP S5663966A JP 13943079 A JP13943079 A JP 13943079A JP 13943079 A JP13943079 A JP 13943079A JP S5663966 A JPS5663966 A JP S5663966A
Authority
JP
Japan
Prior art keywords
formula
pyrimidine derivative
preparation
integer
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13943079A
Other languages
Japanese (ja)
Inventor
Fumio Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Kinzoku Industry Co Ltd
Original Assignee
Tokyo Kinzoku Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Kinzoku Industry Co Ltd filed Critical Tokyo Kinzoku Industry Co Ltd
Priority to JP13943079A priority Critical patent/JPS5663966A/en
Publication of JPS5663966A publication Critical patent/JPS5663966A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A pyrimidine derivative expressed by formula I, II, or III [R and R1 are alkyls, (substituted) phenyls, halogens, alkoxyls, hydroxyls or alkoxycarbonyls; Y and Z are heterocyclic rings; V is H, alkyl, (substituted)phenyl, halogen, alkoxyl, hydroxyl, nitrile, etc.; X is or H; W is hetero-atom (group); l is an integer 0W10; m and k are 0, 1 or 2; n is an integer 1W6].
EXAMPLE: 1-Furfuryl-carbamoyl-5-fluorouracil.
USE: An anticancer agent having no toxicity or side effects.
PROCESS: An amine expressed by the formula H2N(CH2)l(CHR)mY, formula HZ or formula IV is reacted with phosgene and a pyrimidine of formula V.
COPYRIGHT: (C)1981,JPO&Japio
JP13943079A 1979-10-29 1979-10-29 Pyrimidine derivative and its preparation Pending JPS5663966A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13943079A JPS5663966A (en) 1979-10-29 1979-10-29 Pyrimidine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13943079A JPS5663966A (en) 1979-10-29 1979-10-29 Pyrimidine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5663966A true JPS5663966A (en) 1981-05-30

Family

ID=15245008

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13943079A Pending JPS5663966A (en) 1979-10-29 1979-10-29 Pyrimidine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5663966A (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5785374A (en) * 1980-11-18 1982-05-28 Mitsui Toatsu Chem Inc 5-fluorouracil derivative and its preparation
JPS5998091A (en) * 1983-10-31 1984-06-06 Sanwa Kagaku Kenkyusho:Kk Novel organosilicon compound, its preparation and antitumor agent containing said compound as active constituent
JPS60181085A (en) * 1984-02-28 1985-09-14 Chisso Corp 5-fluorouracil derivative
JPS60199887A (en) * 1984-03-26 1985-10-09 Nippon Kasei Kk 5-fluorouracil derivative, its preparation, and antitumor agent
JPS6165890A (en) * 1984-09-10 1986-04-04 Sanwa Kagaku Kenkyusho:Kk Novel organic silicon compound, its production and antitumor agent containing same as active ingredient
JPS61204171A (en) * 1985-03-06 1986-09-10 Terumo Corp 5-fluorouracil derivative and medicinal drug preparation containing same
EP0240352A2 (en) * 1986-04-02 1987-10-07 Chisso Corporation 5-Fluorouracil derivatives and processes for producing thereof
JPS62258367A (en) * 1986-04-02 1987-11-10 Chisso Corp 5-fluorouracil derivative and production thereof
US4810790A (en) * 1986-10-09 1989-03-07 Daikin Industries Ltd. 5-fluorouracil derivatives useful as carcinostatic substances
JP2008507493A (en) * 2004-07-23 2008-03-13 バイエル・クロツプサイエンス・エス・アー 4-pyridinylethylcarboxamide derivatives useful as fungicides
JP2014510743A (en) * 2011-03-31 2014-05-01 シェファー、コンスタンツェ Perfluorinated compounds for non-viral introduction of nucleic acids
JP2015518019A (en) * 2012-05-28 2015-06-25 フォンダツィオーネ・イスティトゥート・イタリアーノ・ディ・テクノロジャＦｏｎｄａｚｉｏｎｅ Ｉｓｔｉｔｕｔｏ Ｉｔａｌｉａｎｏ Ｄｉ Ｔｅｃｎｏｌｏｇｉａ Acid ceramidase inhibitors and their use as pharmaceuticals
DE102014014266B3 (en) * 2014-09-26 2015-08-27 Skw Stickstoffwerke Piesteritz Gmbh Use of pyrazole compounds as dry stress tolerance improvers
CN108640907A (en) * 2018-06-20 2018-10-12 河北中医学院 Uracil-carbazoles conjugate, synthesis and its application
CN109384730A (en) * 2017-08-10 2019-02-26 南京友怡医药科技有限公司 1- { 3- [p- double-(2- chloroethyl) amido] phenylpropyl alcohol amido } formyl -5-fluor-uracil and preparation and application
CN109485641A (en) * 2018-07-19 2019-03-19 河北中医学院 Uracil-carbazoles conjugate, synthesis and its application of a kind of amide key connection

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50148365A (en) * 1973-11-28 1975-11-27
JPS5285179A (en) * 1976-01-08 1977-07-15 Mitsui Toatsu Chem Inc Preparation of carbamoylated 5-fluorouracils
JPS52139080A (en) * 1976-04-26 1977-11-19 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyluracils
JPS5328183A (en) * 1976-08-25 1978-03-16 Mitsui Toatsu Chem Inc 1-carbamoyl-5-fluorouracil derivatives and thier preparation
JPS5359679A (en) * 1976-11-08 1978-05-29 Mitsui Toatsu Chem Inc 1-cyclic carbamoyl-5-fluorouracils and their preparation
JPS5373572A (en) * 1976-12-09 1978-06-30 Mitsui Toatsu Chem Inc 1-(n-hydroxyalkylcarbamoyl)-5-fluorouracils and their preparation
JPS5398974A (en) * 1977-02-07 1978-08-29 Mitsui Toatsu Chem Inc 1-carbamoyl-5-fluorouracils and process for their preparation
JPS53130679A (en) * 1977-04-20 1978-11-14 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyl-uracil
JPS5427578A (en) * 1977-07-29 1979-03-01 Mitsui Toatsu Chem Inc 1-carboxyalkylcarbamoyl-5-fluorouracil derivatives and their preparation
JPS55330A (en) * 1978-06-19 1980-01-05 Eisai Co Ltd 5-fluorouracil compound and antitumor agent comprising it
JPS5581865A (en) * 1978-10-30 1980-06-20 Fujisawa Pharmaceut Co Ltd 5-fluorouracil derivatives and their preparation
JPS5583760A (en) * 1978-12-21 1980-06-24 Ono Pharmaceut Co Ltd Preparation of 5-fluorouracil derivative
JPS5625166A (en) * 1979-08-09 1981-03-10 Banyu Pharmaceut Co Ltd 5-fluorouracil derivative

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50148365A (en) * 1973-11-28 1975-11-27
JPS5285179A (en) * 1976-01-08 1977-07-15 Mitsui Toatsu Chem Inc Preparation of carbamoylated 5-fluorouracils
JPS52139080A (en) * 1976-04-26 1977-11-19 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyluracils
JPS5328183A (en) * 1976-08-25 1978-03-16 Mitsui Toatsu Chem Inc 1-carbamoyl-5-fluorouracil derivatives and thier preparation
JPS5359679A (en) * 1976-11-08 1978-05-29 Mitsui Toatsu Chem Inc 1-cyclic carbamoyl-5-fluorouracils and their preparation
JPS5373572A (en) * 1976-12-09 1978-06-30 Mitsui Toatsu Chem Inc 1-(n-hydroxyalkylcarbamoyl)-5-fluorouracils and their preparation
JPS5398974A (en) * 1977-02-07 1978-08-29 Mitsui Toatsu Chem Inc 1-carbamoyl-5-fluorouracils and process for their preparation
JPS53130679A (en) * 1977-04-20 1978-11-14 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyl-uracil
JPS5427578A (en) * 1977-07-29 1979-03-01 Mitsui Toatsu Chem Inc 1-carboxyalkylcarbamoyl-5-fluorouracil derivatives and their preparation
JPS55330A (en) * 1978-06-19 1980-01-05 Eisai Co Ltd 5-fluorouracil compound and antitumor agent comprising it
JPS5581865A (en) * 1978-10-30 1980-06-20 Fujisawa Pharmaceut Co Ltd 5-fluorouracil derivatives and their preparation
JPS5583760A (en) * 1978-12-21 1980-06-24 Ono Pharmaceut Co Ltd Preparation of 5-fluorouracil derivative
JPS5625166A (en) * 1979-08-09 1981-03-10 Banyu Pharmaceut Co Ltd 5-fluorouracil derivative

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5785374A (en) * 1980-11-18 1982-05-28 Mitsui Toatsu Chem Inc 5-fluorouracil derivative and its preparation
JPS5998091A (en) * 1983-10-31 1984-06-06 Sanwa Kagaku Kenkyusho:Kk Novel organosilicon compound, its preparation and antitumor agent containing said compound as active constituent
JPS60181085A (en) * 1984-02-28 1985-09-14 Chisso Corp 5-fluorouracil derivative
JPS60199887A (en) * 1984-03-26 1985-10-09 Nippon Kasei Kk 5-fluorouracil derivative, its preparation, and antitumor agent
JPS6165890A (en) * 1984-09-10 1986-04-04 Sanwa Kagaku Kenkyusho:Kk Novel organic silicon compound, its production and antitumor agent containing same as active ingredient
EP0178076A2 (en) * 1984-09-10 1986-04-16 Sanwa Kagaku Kenkyusho Co., Ltd. Organo-silicone compounds, process for their manufacture, and pharmaceutical compositions thereof
US4778797A (en) * 1984-09-10 1988-10-18 Sanwa Kagaku Kenkyusho Co., Ltd. Organo-silicon compounds, process for the manufacture of same, and anti-tumor agent comprising the compound
JPH0530833B2 (en) * 1985-03-06 1993-05-11 Terumo Corp
JPS61204171A (en) * 1985-03-06 1986-09-10 Terumo Corp 5-fluorouracil derivative and medicinal drug preparation containing same
EP0240352A2 (en) * 1986-04-02 1987-10-07 Chisso Corporation 5-Fluorouracil derivatives and processes for producing thereof
JPS62258367A (en) * 1986-04-02 1987-11-10 Chisso Corp 5-fluorouracil derivative and production thereof
US4810790A (en) * 1986-10-09 1989-03-07 Daikin Industries Ltd. 5-fluorouracil derivatives useful as carcinostatic substances
JP2008507493A (en) * 2004-07-23 2008-03-13 バイエル・クロツプサイエンス・エス・アー 4-pyridinylethylcarboxamide derivatives useful as fungicides
JP2014510743A (en) * 2011-03-31 2014-05-01 シェファー、コンスタンツェ Perfluorinated compounds for non-viral introduction of nucleic acids
JP2015518019A (en) * 2012-05-28 2015-06-25 フォンダツィオーネ・イスティトゥート・イタリアーノ・ディ・テクノロジャＦｏｎｄａｚｉｏｎｅ Ｉｓｔｉｔｕｔｏ Ｉｔａｌｉａｎｏ Ｄｉ Ｔｅｃｎｏｌｏｇｉａ Acid ceramidase inhibitors and their use as pharmaceuticals
DE102014014266B3 (en) * 2014-09-26 2015-08-27 Skw Stickstoffwerke Piesteritz Gmbh Use of pyrazole compounds as dry stress tolerance improvers
CN109384730A (en) * 2017-08-10 2019-02-26 南京友怡医药科技有限公司 1- { 3- [p- double-(2- chloroethyl) amido] phenylpropyl alcohol amido } formyl -5-fluor-uracil and preparation and application
CN109384730B (en) * 2017-08-10 2022-02-18 南京友怡医药科技有限公司 1- {3- [ p-bis- (2-chloroethyl) amino ] phenylpropylamino } formyl-5-fluorouracil, preparation and application
CN108640907A (en) * 2018-06-20 2018-10-12 河北中医学院 Uracil-carbazoles conjugate, synthesis and its application
CN109485641A (en) * 2018-07-19 2019-03-19 河北中医学院 Uracil-carbazoles conjugate, synthesis and its application of a kind of amide key connection
CN109485641B (en) * 2018-07-19 2020-11-27 河北中医学院 Uracil-carbazole conjugate connected by amide bonds, and synthesis and application thereof

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