JPS5785374A - 5-fluorouracil derivative and its preparation - Google Patents

5-fluorouracil derivative and its preparation

Info

Publication number
JPS5785374A
JPS5785374A JP55161341A JP16134180A JPS5785374A JP S5785374 A JPS5785374 A JP S5785374A JP 55161341 A JP55161341 A JP 55161341A JP 16134180 A JP16134180 A JP 16134180A JP S5785374 A JPS5785374 A JP S5785374A
Authority
JP
Japan
Prior art keywords
fluorouracil
formula
expressed
ethylenedioxyhexyl
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55161341A
Other languages
Japanese (ja)
Inventor
Shoichiro Ozaki
Haruki Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP55161341A priority Critical patent/JPS5785374A/en
Publication of JPS5785374A publication Critical patent/JPS5785374A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 5-fluorouracil derivative expressed by formula I(R is 5- ethylenedioxyhexyl, 5-oxohexyl or 5-hydroxyhexyl).
EXAMPLE: 1-(5-Ethylene dioxyhexylcarbamoyl)-5-fluorouracil.
USE: A carcinostatic agent.
PROCESS: 5-Oxocapronitrile is reacted with ethylene glycol in the presence of an acidic catalyst, e.g. p-toluenesulfonic acid, to form 5-ethylenedioxycapronitrile expressed by formula II, which is then catalytically reduced with lithium aluminum hydride or Raney nickel to give 5-ethylenedioxyhexylamine. The resultant compound is then reacted with 1-chlorocarbonyl-5-fluorouracil to afford the compound expressed by formula I(R is 5-ethylenedioxyhexyl).
COPYRIGHT: (C)1982,JPO&Japio
JP55161341A 1980-11-18 1980-11-18 5-fluorouracil derivative and its preparation Pending JPS5785374A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55161341A JPS5785374A (en) 1980-11-18 1980-11-18 5-fluorouracil derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55161341A JPS5785374A (en) 1980-11-18 1980-11-18 5-fluorouracil derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5785374A true JPS5785374A (en) 1982-05-28

Family

ID=15733233

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55161341A Pending JPS5785374A (en) 1980-11-18 1980-11-18 5-fluorouracil derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5785374A (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50148365A (en) * 1973-11-28 1975-11-27
JPS5277073A (en) * 1975-11-05 1977-06-29 Mitsui Toatsu Chem Inc 1-carbamoyl-5-fluorouracil deruvative and anticancer drug containing s ame as effective component
JPS5373572A (en) * 1976-12-09 1978-06-30 Mitsui Toatsu Chem Inc 1-(n-hydroxyalkylcarbamoyl)-5-fluorouracils and their preparation
JPS53130679A (en) * 1977-04-20 1978-11-14 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyl-uracil
JPS5432487A (en) * 1977-08-17 1979-03-09 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyluracils
JPS5581865A (en) * 1978-10-30 1980-06-20 Fujisawa Pharmaceut Co Ltd 5-fluorouracil derivatives and their preparation
JPS5663966A (en) * 1979-10-29 1981-05-30 Tokyo Kinzoku Kogyo Kk Pyrimidine derivative and its preparation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50148365A (en) * 1973-11-28 1975-11-27
JPS5277073A (en) * 1975-11-05 1977-06-29 Mitsui Toatsu Chem Inc 1-carbamoyl-5-fluorouracil deruvative and anticancer drug containing s ame as effective component
JPS5373572A (en) * 1976-12-09 1978-06-30 Mitsui Toatsu Chem Inc 1-(n-hydroxyalkylcarbamoyl)-5-fluorouracils and their preparation
JPS53130679A (en) * 1977-04-20 1978-11-14 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyl-uracil
JPS5432487A (en) * 1977-08-17 1979-03-09 Mitsui Toatsu Chem Inc Preparation of 1-carbamoyluracils
JPS5581865A (en) * 1978-10-30 1980-06-20 Fujisawa Pharmaceut Co Ltd 5-fluorouracil derivatives and their preparation
JPS5663966A (en) * 1979-10-29 1981-05-30 Tokyo Kinzoku Kogyo Kk Pyrimidine derivative and its preparation

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