IE780397L - Guanines. - Google Patents

Guanines.

Info

Publication number
IE780397L
IE780397L IE780397A IE39778A IE780397L IE 780397 L IE780397 L IE 780397L IE 780397 A IE780397 A IE 780397A IE 39778 A IE39778 A IE 39778A IE 780397 L IE780397 L IE 780397L
Authority
IE
Ireland
Prior art keywords
formula
compound
compounds
prepared
denote
Prior art date
Application number
IE780397A
Other versions
IE46210B1 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IE780397L publication Critical patent/IE780397L/en
Publication of IE46210B1 publication Critical patent/IE46210B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Abstract

9-Hydroxyethoxymethylguanine derivatives of the formula I are prepared by reacting a compound of the formula II with a phosphorylating agent. The resulting compound of the formula I in which W and Z both denote hydrogen can be reacted with a base containing the desired cation or with a corresponding salt to give a compound of the formula I in which W and/or Z denote a pharmaceutically acceptable cation. The compounds of the formula I can also be prepared by the processes indicated in Claims 11 and 15. The compounds of the formula I are active against viruses, in particular against different types of DNA and RNA viruses. <IMAGE> [FR2381781A1]
IE397/78A 1977-02-24 1978-02-24 Phosphorus containing guanine derivatives having antiviral activity IE46210B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77177877A 1977-02-24 1977-02-24
GB5390577 1977-12-24

Publications (2)

Publication Number Publication Date
IE780397L true IE780397L (en) 1978-08-24
IE46210B1 IE46210B1 (en) 1983-03-23

Family

ID=26267373

Family Applications (1)

Application Number Title Priority Date Filing Date
IE397/78A IE46210B1 (en) 1977-02-24 1978-02-24 Phosphorus containing guanine derivatives having antiviral activity

Country Status (27)

Country Link
JP (1) JPS53108999A (en)
AR (2) AR219735A1 (en)
AT (1) AT353286B (en)
AU (1) AU521577B2 (en)
CA (1) CA1094062A (en)
CH (1) CH643858A5 (en)
DD (1) DD134098A5 (en)
DE (1) DE2808096A1 (en)
DK (1) DK147198C (en)
ES (2) ES467300A1 (en)
FI (1) FI68402C (en)
FR (1) FR2381781A1 (en)
GR (1) GR64404B (en)
HU (1) HU178808B (en)
IE (1) IE46210B1 (en)
IL (1) IL54130A0 (en)
IN (1) IN149483B (en)
IT (1) IT1105259B (en)
LU (1) LU79126A1 (en)
MC (1) MC1182A1 (en)
NL (1) NL7802111A (en)
NO (1) NO153260C (en)
NZ (1) NZ186555A (en)
PH (1) PH13996A (en)
PL (1) PL114474B1 (en)
PT (1) PT67706B (en)
SE (1) SE430507B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015584A3 (en) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Nucleotides, methods for their preparation and medicaments
DE3490262T1 (en) * 1983-05-24 1985-11-28 Sri International, Menlo Park, Calif. Antivirus agents
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
FR2733234B1 (en) * 1995-04-21 1997-07-04 Centre Nat Rech Scient DERIVATIVES OF ACYCLOVIR AS ANTIVIRAL AGENTS
AU5511196A (en) * 1995-04-21 1996-11-07 Centre National De La Recherche Scientifique (Cnrs) Acyclovir derivatives as antiviral agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof

Also Published As

Publication number Publication date
DK85178A (en) 1978-08-25
ATA134678A (en) 1979-04-15
NO780644L (en) 1978-08-25
IL54130A0 (en) 1978-04-30
NO153260C (en) 1986-02-12
IN149483B (en) 1981-12-26
FI68402C (en) 1985-09-10
PT67706A (en) 1978-03-01
DE2808096A1 (en) 1978-08-31
AR218718A1 (en) 1980-06-30
CH643858A5 (en) 1984-06-29
FI68402B (en) 1985-05-31
CA1094062A (en) 1981-01-20
DK147198B (en) 1984-05-14
AR219735A1 (en) 1980-09-15
AU3356078A (en) 1979-08-30
PL204885A1 (en) 1979-04-23
DE2808096C2 (en) 1988-02-18
JPS53108999A (en) 1978-09-22
IT1105259B (en) 1985-10-28
NZ186555A (en) 1981-02-11
IE46210B1 (en) 1983-03-23
MC1182A1 (en) 1978-12-22
PL114474B1 (en) 1981-01-31
SE7802140L (en) 1978-08-25
SE430507B (en) 1983-11-21
ES470383A1 (en) 1979-09-16
GR64404B (en) 1980-03-21
AT353286B (en) 1979-11-12
NO153260B (en) 1985-11-04
ES467300A1 (en) 1978-10-16
LU79126A1 (en) 1978-10-17
IT7848192A0 (en) 1978-02-24
NL7802111A (en) 1978-08-28
DK147198C (en) 1984-11-12
FR2381781B1 (en) 1980-04-25
FI780626A (en) 1978-08-25
FR2381781A1 (en) 1978-09-22
HU178808B (en) 1982-06-28
AU521577B2 (en) 1982-04-22
PT67706B (en) 1980-03-04
DD134098A5 (en) 1979-02-07
PH13996A (en) 1980-11-28

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Legal Events

Date Code Title Description
MM4A Patent lapsed