JPS56113795A - 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same - Google Patents
2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the sameInfo
- Publication number
- JPS56113795A JPS56113795A JP1613780A JP1613780A JPS56113795A JP S56113795 A JPS56113795 A JP S56113795A JP 1613780 A JP1613780 A JP 1613780A JP 1613780 A JP1613780 A JP 1613780A JP S56113795 A JPS56113795 A JP S56113795A
- Authority
- JP
- Japan
- Prior art keywords
- deoxy
- acetyl
- antitumor agent
- fluorouridine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The titled compound expressed by the formula (R is heterocyclic ring residue).
EXAMPLE: 3-(Furan-2-carbonyl)-2'-deoxy-3',5'-di-O-acetyl-5-fluorouridine.
USE: An antitumor agent with low toxicity and a powerful antitumor activity.
PROCESS: 2'-Deoxy-3',5'-di-O-acetyl-5-fluorouridine is reacted with an acid halide, e.g. chloride or bromide, of the formula R-CO-hal (hal is halogen) in a solvent, e.g. ether or chloroform, preferably in the presence of a base, e.g. a trialkylamine or pyridine, to give the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1613780A JPS56113795A (en) | 1980-02-13 | 1980-02-13 | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1613780A JPS56113795A (en) | 1980-02-13 | 1980-02-13 | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56113795A true JPS56113795A (en) | 1981-09-07 |
Family
ID=11908099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1613780A Pending JPS56113795A (en) | 1980-02-13 | 1980-02-13 | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56113795A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4605645A (en) * | 1981-12-09 | 1986-08-12 | Teijin Limited | 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54163586A (en) * | 1978-06-10 | 1979-12-26 | Toyama Chemical Co Ltd | Novel 55fluoroo*betaa urizine or 2**deoxyybetaa urizine* derivative * production thereof and antiicancer agent containing same |
-
1980
- 1980-02-13 JP JP1613780A patent/JPS56113795A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54163586A (en) * | 1978-06-10 | 1979-12-26 | Toyama Chemical Co Ltd | Novel 55fluoroo*betaa urizine or 2**deoxyybetaa urizine* derivative * production thereof and antiicancer agent containing same |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4605645A (en) * | 1981-12-09 | 1986-08-12 | Teijin Limited | 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof |
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