JPS56113795A - 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same - Google Patents

2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same

Info

Publication number
JPS56113795A
JPS56113795A JP1613780A JP1613780A JPS56113795A JP S56113795 A JPS56113795 A JP S56113795A JP 1613780 A JP1613780 A JP 1613780A JP 1613780 A JP1613780 A JP 1613780A JP S56113795 A JPS56113795 A JP S56113795A
Authority
JP
Japan
Prior art keywords
deoxy
acetyl
antitumor agent
fluorouridine
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1613780A
Other languages
Japanese (ja)
Inventor
Setsuo Fujii
Bonpei Yasui
Hideo Fukami
Yoshitaka Sako
Tomohisa Miyamoto
Kazuko Ando
Iwao Hashimoto
Yoneichi Kura
Shoichiro Kawai
Yumiko Miyagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUNAI CORP
Funai Pharmaceutical Industries Ltd
Original Assignee
FUNAI CORP
Funai Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUNAI CORP, Funai Pharmaceutical Industries Ltd filed Critical FUNAI CORP
Priority to JP1613780A priority Critical patent/JPS56113795A/en
Publication of JPS56113795A publication Critical patent/JPS56113795A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The titled compound expressed by the formula (R is heterocyclic ring residue).
EXAMPLE: 3-(Furan-2-carbonyl)-2'-deoxy-3',5'-di-O-acetyl-5-fluorouridine.
USE: An antitumor agent with low toxicity and a powerful antitumor activity.
PROCESS: 2'-Deoxy-3',5'-di-O-acetyl-5-fluorouridine is reacted with an acid halide, e.g. chloride or bromide, of the formula R-CO-hal (hal is halogen) in a solvent, e.g. ether or chloroform, preferably in the presence of a base, e.g. a trialkylamine or pyridine, to give the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
JP1613780A 1980-02-13 1980-02-13 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same Pending JPS56113795A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1613780A JPS56113795A (en) 1980-02-13 1980-02-13 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1613780A JPS56113795A (en) 1980-02-13 1980-02-13 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same

Publications (1)

Publication Number Publication Date
JPS56113795A true JPS56113795A (en) 1981-09-07

Family

ID=11908099

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1613780A Pending JPS56113795A (en) 1980-02-13 1980-02-13 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same

Country Status (1)

Country Link
JP (1) JPS56113795A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605645A (en) * 1981-12-09 1986-08-12 Teijin Limited 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54163586A (en) * 1978-06-10 1979-12-26 Toyama Chemical Co Ltd Novel 55fluoroo*betaa urizine or 2**deoxyybetaa urizine* derivative * production thereof and antiicancer agent containing same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54163586A (en) * 1978-06-10 1979-12-26 Toyama Chemical Co Ltd Novel 55fluoroo*betaa urizine or 2**deoxyybetaa urizine* derivative * production thereof and antiicancer agent containing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605645A (en) * 1981-12-09 1986-08-12 Teijin Limited 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof

Similar Documents

Publication Publication Date Title
JPS5432460A (en) Cycloalkylidenemethylphenylacetic acid derivative and their preparation
JPS56115799A (en) 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivative, its preparation, and antitumor agnet containing the same
JPS57116074A (en) Novel camptothecin derivative and its preparation
JPS56113795A (en) 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same
JPS5751000A (en) Ester derivative of alkoxybenzoyldeoxyfluorouridine
JPS54151987A (en) Preparation of 3',5'-disubstituted-2'-deoxy-beta-uridines and 2'-deoxy-beta-urdines
JPS5528955A (en) Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same.
JPS5424882A (en) Novel heterocyclic compounds and their preparation
JPS5639090A (en) 5-substituted uracil derivative and its preparation
JPS5473775A (en) Isoxazoline-3-one derivative
JPS56115798A (en) 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation, and antitumor agent containing the same
JPS5427580A (en) Selective herbicides
JPS5387330A (en) Novel thiohydroxymate derivative, its preparation and bactericideand herbicide containing the same
JPS5735588A (en) Carbostyrile derivative
JPS56156277A (en) 5-fluorouracil derivative and its preparation
JPS5714598A (en) 5-substituted-1-beta-d-arabinofuranosyluracil derivative and its preparation
JPS5219685A (en) Preparation of novel 2,3-dioxopiperazine derivatives
JPS5610121A (en) Preparation of organic fluorocompound
JPS5427573A (en) 3,4-dihydrocarbostyril derivatives
JPS5711975A (en) Aminophenyltetrazole derivative and salt thereof
JPS5547651A (en) Production of sulfoxyimine
JPS643190A (en) Damavaricin fc derivative
JPS5629575A (en) Preparation of pyrazole derivative
JPS57212159A (en) Production of n-((1-ethyl-2-pyrrolidinyl)methyl)-2- methoxy-5-sulfamoylbenzamide
JPS5629579A (en) Preparation of novel cyclic urethane compound