JPS5473775A - Isoxazoline-3-one derivative - Google Patents

Isoxazoline-3-one derivative

Info

Publication number
JPS5473775A
JPS5473775A JP13961377A JP13961377A JPS5473775A JP S5473775 A JPS5473775 A JP S5473775A JP 13961377 A JP13961377 A JP 13961377A JP 13961377 A JP13961377 A JP 13961377A JP S5473775 A JPS5473775 A JP S5473775A
Authority
JP
Japan
Prior art keywords
isoxazoline
formula
derivative
halogen
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13961377A
Other languages
Japanese (ja)
Inventor
Mitsuo Nagano
Junichi Sakai
Muneharu Mizukai
Norio Nakamura
Hidekazu Mitsusaka
Shinsaku Kobayashi
Kazuo Tomita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP13961377A priority Critical patent/JPS5473775A/en
Publication of JPS5473775A publication Critical patent/JPS5473775A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An isoxazoline-3-one derivative of formula I: (R1 is halogen; R2 is H, lower alkyl, aryl, or heterocyclic group; R3 is lower alkyl, lower alkenyl, aralkenyl, lower alkynyl, or aralkynyl group).
EXAMPLE: 2-Allyl-4-chloro-5-phenyl-4-isoxazoline-3-one.
USE: Pharmaceuticals having auti-inflammatory, analgesic, and artipyretic actions.
PROCESS: A 3-hydroxy isoxazole of formula I is reacted with a halogen compound of formula III: (X is halogen, e.g. Cl, Br, I, etc.) in an inert solvent, e.g. methanol, benzene, etc. in the presence or absence of a base, e.g. sodium, potassium hydroxides, etc. at 0W150°C, preferably 20W130°C to give the isoxazoline-3-one derivative of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP13961377A 1977-11-21 1977-11-21 Isoxazoline-3-one derivative Pending JPS5473775A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13961377A JPS5473775A (en) 1977-11-21 1977-11-21 Isoxazoline-3-one derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13961377A JPS5473775A (en) 1977-11-21 1977-11-21 Isoxazoline-3-one derivative

Publications (1)

Publication Number Publication Date
JPS5473775A true JPS5473775A (en) 1979-06-13

Family

ID=15249359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13961377A Pending JPS5473775A (en) 1977-11-21 1977-11-21 Isoxazoline-3-one derivative

Country Status (1)

Country Link
JP (1) JPS5473775A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273744A2 (en) * 1986-12-26 1988-07-06 Sankyo Company Limited Centrally-acting muscle relaxants
JPH02132471A (en) * 1988-11-12 1990-05-21 Ricoh Co Ltd Copying machine
JPH02132468A (en) * 1988-11-12 1990-05-21 Ricoh Co Ltd Copying machine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273744A2 (en) * 1986-12-26 1988-07-06 Sankyo Company Limited Centrally-acting muscle relaxants
JPH02132471A (en) * 1988-11-12 1990-05-21 Ricoh Co Ltd Copying machine
JPH02132468A (en) * 1988-11-12 1990-05-21 Ricoh Co Ltd Copying machine

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