JPS5473774A - Isoxazoline-3-one derivative - Google Patents

Isoxazoline-3-one derivative

Info

Publication number
JPS5473774A
JPS5473774A JP13961277A JP13961277A JPS5473774A JP S5473774 A JPS5473774 A JP S5473774A JP 13961277 A JP13961277 A JP 13961277A JP 13961277 A JP13961277 A JP 13961277A JP S5473774 A JPS5473774 A JP S5473774A
Authority
JP
Japan
Prior art keywords
isoxazoline
formula
derivative
phenyl
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13961277A
Other languages
Japanese (ja)
Inventor
Mitsuo Nagano
Junichi Sakai
Muneharu Mizukai
Norio Nakamura
Hidekazu Mitsusaka
Shinsaku Kobayashi
Kazuo Tomita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP13961277A priority Critical patent/JPS5473774A/en
Publication of JPS5473774A publication Critical patent/JPS5473774A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An isoxazoline-3-one derivative of formula I: (R1 is H or lower alkyl group; R2 is aryl, heterocyclic group; R3 is lower alkyl, lower alkenyl, aralkenyl, lower alkynyl, or aralkynyl group).
EXAMPLE: 2-(3-Phenyl-2-propynyl)-5-phenyl-4-isoxazoline-3-one.
USE: Pharmaceuticals having anti-inflammatory, analgesic, and antipyretic actions.
PROCESS: A 3-hydroxyisoxazole is reacted with 1.0W2.0 moles of a halogen compound of formula III: (X is halogen, e.g. Cl, Br, I, etc.) in an inert solvent, e.g. benzene, methanol, etc., if necessary, in the presence of a base, e.g. potassium, sodium hydroxides, etc. at 0W150°C, preferably 20W130°C to give the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP13961277A 1977-11-21 1977-11-21 Isoxazoline-3-one derivative Pending JPS5473774A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13961277A JPS5473774A (en) 1977-11-21 1977-11-21 Isoxazoline-3-one derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13961277A JPS5473774A (en) 1977-11-21 1977-11-21 Isoxazoline-3-one derivative

Publications (1)

Publication Number Publication Date
JPS5473774A true JPS5473774A (en) 1979-06-13

Family

ID=15249334

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13961277A Pending JPS5473774A (en) 1977-11-21 1977-11-21 Isoxazoline-3-one derivative

Country Status (1)

Country Link
JP (1) JPS5473774A (en)

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