JPS57200390A - Preparation of xanthine derivative - Google Patents

Preparation of xanthine derivative

Info

Publication number
JPS57200390A
JPS57200390A JP8478281A JP8478281A JPS57200390A JP S57200390 A JPS57200390 A JP S57200390A JP 8478281 A JP8478281 A JP 8478281A JP 8478281 A JP8478281 A JP 8478281A JP S57200390 A JPS57200390 A JP S57200390A
Authority
JP
Japan
Prior art keywords
compound shown
lewis acid
compound
dimethylxanthine
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8478281A
Other languages
Japanese (ja)
Inventor
Takumi Matsumura
Yasuhiro Koyagi
Akihiro Yashiro
Hiroshi Kawahara
Akira Yokozuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daitou Koueki Kk
Daito Koeki KK
Original Assignee
Daitou Koueki Kk
Daito Koeki KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daitou Koueki Kk, Daito Koeki KK filed Critical Daitou Koueki Kk
Priority to JP8478281A priority Critical patent/JPS57200390A/en
Publication of JPS57200390A publication Critical patent/JPS57200390A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound having a vasodilating action and a promoting action on the deformation state of erythrocyte in high yield, by reacting 1-(3-butenyl)-3,7-dimethylxanthine with acetyl chloride in the presence of a Lewis acid, followed by reducing the reaction product.
CONSTITUTION: A compound shown by the formulaIis reacted with equivalentW 1.5 equivalent based on the compound of acetyl chloride in the presence of a Lewis acid in a solvent such as dichloromethane at -10W40°C, to give a compound shown by the formula II. The amount of the Lewis acid used is 6W10 equivalent based on the compound shown by the formulaI. The compound shown by the formulaIas a starting material is obtained easily in high yield by reacting 3-bromo-1-butene with an alakli metal salt of 3,7-dimethylxanthine.
COPYRIGHT: (C)1982,JPO&Japio
JP8478281A 1981-06-02 1981-06-02 Preparation of xanthine derivative Pending JPS57200390A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8478281A JPS57200390A (en) 1981-06-02 1981-06-02 Preparation of xanthine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8478281A JPS57200390A (en) 1981-06-02 1981-06-02 Preparation of xanthine derivative

Publications (1)

Publication Number Publication Date
JPS57200390A true JPS57200390A (en) 1982-12-08

Family

ID=13840259

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8478281A Pending JPS57200390A (en) 1981-06-02 1981-06-02 Preparation of xanthine derivative

Country Status (1)

Country Link
JP (1) JPS57200390A (en)

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