JPS57200390A - Preparation of xanthine derivative - Google Patents
Preparation of xanthine derivativeInfo
- Publication number
- JPS57200390A JPS57200390A JP8478281A JP8478281A JPS57200390A JP S57200390 A JPS57200390 A JP S57200390A JP 8478281 A JP8478281 A JP 8478281A JP 8478281 A JP8478281 A JP 8478281A JP S57200390 A JPS57200390 A JP S57200390A
- Authority
- JP
- Japan
- Prior art keywords
- compound shown
- lewis acid
- compound
- dimethylxanthine
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound having a vasodilating action and a promoting action on the deformation state of erythrocyte in high yield, by reacting 1-(3-butenyl)-3,7-dimethylxanthine with acetyl chloride in the presence of a Lewis acid, followed by reducing the reaction product.
CONSTITUTION: A compound shown by the formulaIis reacted with equivalentW 1.5 equivalent based on the compound of acetyl chloride in the presence of a Lewis acid in a solvent such as dichloromethane at -10W40°C, to give a compound shown by the formula II. The amount of the Lewis acid used is 6W10 equivalent based on the compound shown by the formulaI. The compound shown by the formulaIas a starting material is obtained easily in high yield by reacting 3-bromo-1-butene with an alakli metal salt of 3,7-dimethylxanthine.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8478281A JPS57200390A (en) | 1981-06-02 | 1981-06-02 | Preparation of xanthine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8478281A JPS57200390A (en) | 1981-06-02 | 1981-06-02 | Preparation of xanthine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57200390A true JPS57200390A (en) | 1982-12-08 |
Family
ID=13840259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8478281A Pending JPS57200390A (en) | 1981-06-02 | 1981-06-02 | Preparation of xanthine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57200390A (en) |
-
1981
- 1981-06-02 JP JP8478281A patent/JPS57200390A/en active Pending
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