JPS5598188A - Novel cephalosporin and its preparation - Google Patents

Novel cephalosporin and its preparation

Info

Publication number
JPS5598188A
JPS5598188A JP553779A JP553779A JPS5598188A JP S5598188 A JPS5598188 A JP S5598188A JP 553779 A JP553779 A JP 553779A JP 553779 A JP553779 A JP 553779A JP S5598188 A JPS5598188 A JP S5598188A
Authority
JP
Japan
Prior art keywords
formula
fluorouracil
compound
preparation
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP553779A
Other languages
Japanese (ja)
Inventor
Fujio Matsuda
Kozo Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP553779A priority Critical patent/JPS5598188A/en
Publication of JPS5598188A publication Critical patent/JPS5598188A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formula I [R1 is (un)substituted alkyl, cycloalkyl, cycloalkenyl group, etc.; X is O or S; Y is substituent which does not take part in the reaction], its salt or ester.
EXAMPLE: 7-[ D-α-Fluorouracil-1-carbonylaminophenylacetamide ]-3-methyl-3-cephem-4-carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria, having carcinostatic actions.
PROCESS: A cephalosporin of formula II or its derivative is reacted with a reactive derivative of 5-fluorouracil of formula III (Z is F, Cl, Br, I, H, or 1W5C alkoxy group), e.g. an acid halide, in the presence of a base, e.g. an alkali hydroxide, as a reaction accelerator or neutralizing agent in an inert solvent, e.g. methanol, at -50W80°C to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP553779A 1979-01-23 1979-01-23 Novel cephalosporin and its preparation Pending JPS5598188A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP553779A JPS5598188A (en) 1979-01-23 1979-01-23 Novel cephalosporin and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP553779A JPS5598188A (en) 1979-01-23 1979-01-23 Novel cephalosporin and its preparation

Publications (1)

Publication Number Publication Date
JPS5598188A true JPS5598188A (en) 1980-07-25

Family

ID=11613932

Family Applications (1)

Application Number Title Priority Date Filing Date
JP553779A Pending JPS5598188A (en) 1979-01-23 1979-01-23 Novel cephalosporin and its preparation

Country Status (1)

Country Link
JP (1) JPS5598188A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62258367A (en) * 1986-04-02 1987-11-10 Chisso Corp 5-fluorouracil derivative and production thereof
EP0705606A1 (en) * 1994-09-21 1996-04-10 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62258367A (en) * 1986-04-02 1987-11-10 Chisso Corp 5-fluorouracil derivative and production thereof
EP0705606A1 (en) * 1994-09-21 1996-04-10 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Use of 5-Thia-1,4-diazabicyclo [4.2.0] octane-3,8-dioxo compounds in antitumor therapy

Similar Documents

Publication Publication Date Title
JPS565487A (en) Cephalosporin compound, its preparation, and antimicrobial comprising it
JPS5573686A (en) Novel penicillin
JPS5598188A (en) Novel cephalosporin and its preparation
JPS55147284A (en) Novel beta-lactam derivative and its preparation
JPS54138590A (en) 7-methoxycephalosporin compound, its preparation, and anti-bacterial agent containing the same
JPS5746990A (en) Novel cephalexin derivative and its preparation
JPS5524135A (en) Penicillin derivative and its preparation
JPS54103888A (en) Novel 7alpha-methoxy-cephalosporin
JPS55136287A (en) Novel penicillin, cephalosporin, and their preparation
JPS5646885A (en) Novel cephamycin ester and its preparation
JPS5625188A (en) 7alpha-methoxycephalosporin
JPS54144392A (en) Cephalosporin derivative
JPS5448784A (en) N,n-dimethylacetamide adduct of cephalosporin and its preparation
JPS5540617A (en) Mitomycin derivative
JPS56133260A (en) Azetidine derivative and its preparation
JPS57165389A (en) Novel penicillin and cephalosporin compound
JPS5466693A (en) Cephalosporin derivative and its preparation
JPS56128787A (en) Cephalosporin derivative and its preparation
JPS5531044A (en) Penicillanic acid derivative and its preparation
EP0111569A4 (en) Hydroxyalkanesulfonic acids and their derivatives, and process for their preparation.
JPS57108091A (en) Novel carbapenem type antibiotic and its preparation
JPS5799591A (en) 7alpha-methoxy-3-cephem derivative, its preparation and antibacterial agent comprising it
JPS565482A (en) Penicillin derivative and its salt
JPS6442490A (en) Substituted oxycarbonylaminocephem compound
JPS5585594A (en) Cephem compound and their preparation