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Tanabe Seiyaku Co Ltd
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Tanabe Seiyaku Co Ltd
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Priority to JP13181577ApriorityCriticalpatent/JPS5466693A/en
Publication of JPS5466693ApublicationCriticalpatent/JPS5466693A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:Cephalosporin derivative of formula I (R1 is H, tert-lower alkyloxycarbonyl; R2 is H, OH; R3 is lower aliphatic acyloxy, -S-Y-R; Y is triazole ring tetrazole ring, thiazole ring; R is H, amino, lower alkyl, carboxy-lower-alkylthio), and its salt. EXAMPLE.:7-[N-(2-tert-butyloxycarbonylaminomethyl-1,3-thiazol-4-yl)carbonyl- D-phenylglycyl]amino-3-acetoxymethyl-Δ3-cephem-4-carboxylic acid.
USE: Antibacterial agent. Effective to gram-positive and gram-negative bacteria; also effective to Pseudomonas aeruginosa, and indole-producing bacteria.
PROCESS: The compound IV is prepared by reacting the compound II (R4 is tert lower alkyloxycarbonyl) with the compound III (R5 is lower aliphatic acyloxy).
COPYRIGHT: (C)1979,JPO&Japio
JP13181577A1977-11-021977-11-02Cephalosporin derivative and its preparation
PendingJPS5466693A
(en)