JPS5799592A - Novel cephalosporins - Google Patents

Novel cephalosporins

Info

Publication number
JPS5799592A
JPS5799592A JP55175263A JP17526380A JPS5799592A JP S5799592 A JPS5799592 A JP S5799592A JP 55175263 A JP55175263 A JP 55175263A JP 17526380 A JP17526380 A JP 17526380A JP S5799592 A JPS5799592 A JP S5799592A
Authority
JP
Japan
Prior art keywords
compound shown
formula
formulai
acetamido
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55175263A
Other languages
Japanese (ja)
Other versions
JPS6052755B2 (en
Inventor
Hiroshi Sadaki
Hirokazu Narita
Hiroyuki Imaizumi
Yoshinori Konishi
Takihiro Inaba
Tatsuo Hirakawa
Hideo Taki
Masaru Tai
Yasuo Watanabe
Isamu Saikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP55175263A priority Critical patent/JPS6052755B2/en
Priority to NZ198350A priority patent/NZ198350A/en
Priority to CA000386066A priority patent/CA1204735A/en
Priority to GB8128011A priority patent/GB2089339B/en
Priority to PH26215A priority patent/PH18072A/en
Priority to AU75438/81A priority patent/AU550330B2/en
Priority to IN1045/CAL/81A priority patent/IN155375B/en
Priority to IL74413A priority patent/IL74413A/en
Priority to IL63892A priority patent/IL63892A/en
Priority to DE3152932A priority patent/DE3152932C2/de
Priority to DE3152935A priority patent/DE3152935C2/de
Priority to IT49348/81A priority patent/IT1172201B/en
Priority to DE3152934A priority patent/DE3152934C2/de
Priority to NL8104386A priority patent/NL8104386A/en
Priority to PL1981238230A priority patent/PL135611B1/en
Priority to DE19813137854 priority patent/DE3137854A1/en
Priority to PL1981233143A priority patent/PL135446B1/en
Priority to US06/304,912 priority patent/US4489072A/en
Priority to DE3152931A priority patent/DE3152931C2/de
Priority to MX7609A priority patent/MX155025A/en
Priority to DK421881A priority patent/DK163877C/en
Priority to CS827529A priority patent/CS236491B2/en
Priority to FI812980A priority patent/FI75575C/en
Priority to HU812759A priority patent/HU185850B/en
Priority to KR1019810003579A priority patent/KR860000487B1/en
Priority to SU813340952A priority patent/SU1190987A3/en
Priority to AT0410981A priority patent/AT375082B/en
Priority to NO813252A priority patent/NO161117C/en
Priority to PT73727A priority patent/PT73727B/en
Priority to CS817055A priority patent/CS236471B2/en
Priority to CS827530A priority patent/CS236492B2/en
Priority to SE8105658A priority patent/SE453090B/en
Priority to ES505760A priority patent/ES505760A0/en
Priority to LU83650A priority patent/LU83650A1/en
Priority to FR8118156A priority patent/FR2509310B1/en
Priority to RO81105405A priority patent/RO82689A/en
Priority to CH4520/84A priority patent/CH652130A5/en
Priority to RO112113A priority patent/RO86825B/en
Priority to DD81233599A priority patent/DD202436A5/en
Priority to CH4521/84A priority patent/CH652128A5/en
Priority to CH6202/81A priority patent/CH652129A5/en
Priority to RO112112A priority patent/RO86824B/en
Priority to RO112111A priority patent/RO86823B/en
Priority to DD81247292A priority patent/DD208351A5/en
Priority to CH4519/84A priority patent/CH651837A5/en
Priority to EG543/81A priority patent/EG17373A/en
Publication of JPS5799592A publication Critical patent/JPS5799592A/en
Priority to ES514671A priority patent/ES8306157A1/en
Priority to ES514670A priority patent/ES514670A0/en
Priority to ES514669A priority patent/ES8306155A1/en
Priority to FR8215992A priority patent/FR2511377B1/en
Priority to SU823529508A priority patent/SU1249017A1/en
Priority to SU823523100A priority patent/SU1274625A3/en
Priority to SU823520351A priority patent/SU1418329A1/en
Priority to AR29180883A priority patent/AR240645A1/en
Priority to AT0055583A priority patent/AT378962B/en
Priority to AT0055483A priority patent/AT378961B/en
Priority to AT0055683A priority patent/AT378193B/en
Priority to PH29077A priority patent/PH20221A/en
Priority to PH29075A priority patent/PH19251A/en
Priority to PH29078A priority patent/PH18484A/en
Priority to PH29076A priority patent/PH19147A/en
Priority to CA000435930A priority patent/CA1200541A/en
Priority to GB08402250A priority patent/GB2136420B/en
Priority to GB08402249A priority patent/GB2135304B/en
Priority to IN602/CAL/84A priority patent/IN158590B/en
Priority to IN601/CAL/84A priority patent/IN158589B/en
Priority to IN603/CAL/84A priority patent/IN159126B/en
Priority to US06/654,681 priority patent/US4673738A/en
Priority to IL74413A priority patent/IL74413A0/en
Priority to AU49862/85A priority patent/AU558649B2/en
Priority to AU49861/85A priority patent/AU568033B2/en
Publication of JPS6052755B2 publication Critical patent/JPS6052755B2/en
Priority to SE8600192A priority patent/SE468478B/en
Priority to SE8600195A priority patent/SE468477B/en
Priority to SE8600193A priority patent/SE468479B/en
Priority to SE8600194A priority patent/SE468476B/en
Priority to KR1019860002383A priority patent/KR860000932B1/en
Priority to FI870153A priority patent/FI80041C/en
Priority to US07/022,433 priority patent/US4879381A/en
Priority to US07/707,221 priority patent/US5144027A/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by the formulaI(R1 is H or carboxyl- protecting group; R2 is aromatic hydrocarbon group, acylamino, etc.; R3 is H or alkoxy; R4 is H or halogen; R5 is H or amino; A is -CH2-, etc.; Z is S,S→O; one of dotted lines in the cephem ring is double bond) and its salt.
EXAMPLE: 7-[2-(2-Aminothiazole-4-yl)acetamido]-3-[2-(5-acetamido-1,2,3,4-tetrazolyl) methyl]-Δ3-cephem-4-carboxylic acid.
USE: An antibacterial agent effective against Gram-positive and Gram-negative bacteria. Stable to β-lactamse, having low toxicity.
PROCESS: A compound shown by the formula II or its salt is reacted with an aromatic hydrocarbon, etc. in an organic solvent in the presence of an acid, etc., to give a compound shown by the formula III. This compound is reacted with a compound shown by the formula IV, to give shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP55175263A 1980-09-25 1980-12-13 New cephalosporins Expired JPS6052755B2 (en)

Priority Applications (79)

Application Number Priority Date Filing Date Title
JP55175263A JPS6052755B2 (en) 1980-12-13 1980-12-13 New cephalosporins
NZ198350A NZ198350A (en) 1980-09-25 1981-09-14 Cephalosporins and intermediates;pharmaceutical compositions
CA000386066A CA1204735A (en) 1980-09-25 1981-09-16 Cephalosporins, processes for producing the same, intermediates thereof and process for producing the intermediates
GB8128011A GB2089339B (en) 1980-09-25 1981-09-16 Novel cephalosporins processes for producing the same intermediates thereof and process for producing the intermediates
PH26215A PH18072A (en) 1980-09-25 1981-09-16 Cephalosporins
AU75438/81A AU550330B2 (en) 1980-09-25 1981-09-17 Cephalosporin derivatives with a broad antibacterial spectrum 276
IN1045/CAL/81A IN155375B (en) 1980-09-25 1981-09-19
IL74413A IL74413A (en) 1980-12-13 1981-09-20 7-(4-halo-3-oxobutyramido)-and 7-(4-halo-2-hydroxyamino-3-oxobutyramido)-cephalosporin derivatives
IL63892A IL63892A (en) 1980-11-12 1981-09-20 7-(2-(aminothiazol-4yl)acetamido)cephalosporin derivatives,processes for producing the same and pharmaceutical compositions comprising them
DE3152932A DE3152932C2 (en) 1980-09-25 1981-09-23
DE3152935A DE3152935C2 (en) 1980-09-25 1981-09-23
IT49348/81A IT1172201B (en) 1980-09-25 1981-09-23 CEPHALOSPORINS AND THEIR INTERMEDIATES RELATIVE PODUCTION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE3152934A DE3152934C2 (en) 1980-09-25 1981-09-23
NL8104386A NL8104386A (en) 1980-09-25 1981-09-23 CEPHALOSPORINS, PROCESSES FOR THE PREPARATION THEREOF, INTERMEDIATE PRODUCTS, METHOD FOR PREPARING THE INTERMEDIATE PRODUCTS, AND PHARMACEUTICAL PREPARATIONS CONTAINING THE CEPHALOSPORINES AS AN ACTIVE COMPONENT.
PL1981238230A PL135611B1 (en) 1980-12-13 1981-09-23 Method of obtaining novel cephalosporinic derivatives
DE19813137854 DE3137854A1 (en) 1980-09-25 1981-09-23 NEW CEPHALOSPORINE, METHOD FOR PRODUCING THE SAME, INTERMEDIATE STAGES AND METHOD FOR PRODUCING THE INTERMEDIATE STAGE
PL1981233143A PL135446B1 (en) 1980-12-13 1981-09-23 Method of obtaining novel cephalosporinic derivatives
US06/304,912 US4489072A (en) 1980-09-25 1981-09-23 Cephalosporins
DE3152931A DE3152931C2 (en) 1980-09-25 1981-09-23
MX7609A MX155025A (en) 1980-09-25 1981-09-24 PROCEDURE TO PRODUCE CEPHALOSPORINS
DK421881A DK163877C (en) 1980-09-25 1981-09-24 ANALOGY PROCEDURE FOR THE PREPARATION OF HIS UNKNOWN CEPHALOSPORINES
CS827529A CS236491B2 (en) 1980-12-13 1981-09-24 Method of cephalosporines preparation
FI812980A FI75575C (en) 1980-09-25 1981-09-24 Process for the preparation of novel cephalosporins.
HU812759A HU185850B (en) 1980-09-25 1981-09-24 Process for preparing 7-/ /thiazol-4-yl/-acetamido- or hydroxy-imino- or alkoxy-imino-acetamido/ -delta up 3 -cefem-4-carboxylic acid derivatives
KR1019810003579A KR860000487B1 (en) 1980-09-25 1981-09-24 Process for preparing cephalosporins
SU813340952A SU1190987A3 (en) 1980-12-13 1981-09-24 Method of producing cephalosporin derivatives or salts thereof
AT0410981A AT375082B (en) 1980-09-25 1981-09-24 METHOD FOR PRODUCING NEW CEPHALOSPORINES
NO813252A NO161117C (en) 1980-09-25 1981-09-24 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE CEPHALOSPORIN DERIVATIVES.
PT73727A PT73727B (en) 1980-09-25 1981-09-24 Novel cephalosporins processes for producing the same intermediates thereof and process for producing the inter- mediates
CS817055A CS236471B2 (en) 1980-12-13 1981-09-24 Method of cephalosporines production
CS827530A CS236492B2 (en) 1980-12-13 1981-09-24 Method of cephalosporines preparation
SE8105658A SE453090B (en) 1980-09-25 1981-09-24 NEW CEPHALOSPORIN DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL COMPOSITION THEREOF
ES505760A ES505760A0 (en) 1980-09-25 1981-09-24 A PROCEDURE FOR THE PRODUCTION OF NEW CEPHALOSPORINS.
LU83650A LU83650A1 (en) 1980-09-25 1981-09-24 NOVEL CEPHALOSPORINS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR8118156A FR2509310B1 (en) 1980-09-25 1981-09-25 NOVEL CEPHALOSPORINS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
RO81105405A RO82689A (en) 1980-09-25 1981-09-25 PROCESS FOR THE PREPARATION OF CEPHALOSPORINS
CH4520/84A CH652130A5 (en) 1980-09-25 1981-09-25 INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF NEW cephalosporins.
RO112113A RO86825B (en) 1980-09-25 1981-09-25 Process for the preparation of 7-amino-3-methyl-substituted-delta3-cefem-4-carboxylic acids
DD81233599A DD202436A5 (en) 1980-09-25 1981-09-25 PROCESS FOR THE PREPARATION OF NEW CEPHALOSPORINES
CH4521/84A CH652128A5 (en) 1980-09-25 1981-09-25 INTERMEDIATE PRODUCTS FOR PRODUCING NEW CEPHALOSPORINES AND METHOD FOR PRODUCING THE SAME.
CH6202/81A CH652129A5 (en) 1980-09-25 1981-09-25 NEW CEPHALOSPORINE, METHOD FOR THE PRODUCTION THEREOF.
RO112112A RO86824B (en) 1980-09-25 1981-09-25 Process for the preparation of cephalosporins
RO112111A RO86823B (en) 1980-09-25 1981-09-25 Process for the preparation of cephalosporins
DD81247292A DD208351A5 (en) 1980-09-25 1981-09-25 METHOD OF GENERATING A 7- (SUBSTATION OR SUBSTYLE-AMIONO) -3- (SUBST.-METHYL) -ELTA HIGH 3-CEPHEM-4-CARBON ACID
CH4519/84A CH651837A5 (en) 1980-09-25 1981-09-25 INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF NEW CEPHALOSPORINES.
EG543/81A EG17373A (en) 1980-09-25 1981-09-26 Novel cephalosporins process for production the same intermediates thereof and process for producting the intermediates
ES514671A ES8306157A1 (en) 1980-09-25 1982-08-02 7-(substituted or unsubstituted amino) 3-substituted methyl-3cephem-4-carboxylic acid
ES514670A ES514670A0 (en) 1980-09-25 1982-08-02 A PROCEDURE FOR THE PRODUCTION OF NEW CEPHALOSPORINS.
ES514669A ES8306155A1 (en) 1980-09-25 1982-08-02 7-(substituted or unsubstituted amino) 3-substituted methyl-3cephem-4-carboxylic acid
FR8215992A FR2511377B1 (en) 1980-09-25 1982-09-22 NEW CEPHALOSPORINS AND THEIR SALTS
SU823529508A SU1249017A1 (en) 1980-12-13 1982-12-09 Cephalosporins as intermediate products in synthesis of cephalosporins possessing antibacterial properties
SU823523100A SU1274625A3 (en) 1980-12-13 1982-12-09 Method of producing cephalosporin or salts thereof
SU823520351A SU1418329A1 (en) 1980-12-13 1982-12-09 7-acylamidecephalosporins manifesting antibacterial properties
AR29180883A AR240645A1 (en) 1980-09-25 1983-01-07 Process for the preparation of new cephalosporines
AT0055583A AT378962B (en) 1980-09-25 1983-02-18 METHOD FOR PRODUCING NEW CEPHALOSPORINES
AT0055483A AT378961B (en) 1980-09-25 1983-02-18 METHOD FOR PRODUCING NEW CEPHALOSPORINES
AT0055683A AT378193B (en) 1980-09-25 1983-02-18 METHOD FOR PRODUCING 7- (SUBSTITUTED OR UNSUBSTITUTED AMINO) -3- (SUBSTITUTED METHYL) -DELTA3-CEPHEM-4-CARBONIC ACIDS
PH29077A PH20221A (en) 1980-09-25 1983-06-17 Process for producing novel cephalosporins
PH29075A PH19251A (en) 1980-09-25 1983-06-17 Process for producing novel cephalosporin
PH29078A PH18484A (en) 1980-09-25 1983-06-17 Process for producing novel cephalosporins
PH29076A PH19147A (en) 1980-09-25 1983-06-17 Process for producing novel cephalosporin
CA000435930A CA1200541A (en) 1980-09-25 1983-09-01 Cephalosporins, processes for producing the same, intermediates thereof and process for producing the intermediates
GB08402250A GB2136420B (en) 1980-09-25 1984-01-27 Cephalosporin derivatives
GB08402249A GB2135304B (en) 1980-09-25 1984-01-27 7-amino-3-(triazolyl or tetrazolyl)methyl-.3-cephem-4-carboxylic acidss
IN602/CAL/84A IN158590B (en) 1980-09-25 1984-08-29
IN601/CAL/84A IN158589B (en) 1980-09-25 1984-08-29
IN603/CAL/84A IN159126B (en) 1980-09-25 1984-08-29
US06/654,681 US4673738A (en) 1980-09-25 1984-09-26 Novel intermediates of cephalosporins and process for producing 7-(substituted or unsubstituted amino)-3-substituted methyl-Δ3 -cephem-4-carboxylic acids
IL74413A IL74413A0 (en) 1980-12-13 1985-02-21 Novel cephalosporins
AU49862/85A AU558649B2 (en) 1980-09-25 1985-11-13 Preparation of 7-amino-3-triazolyl or tetrazolylmethylcephem -4- carboxylic acid derivatives
AU49861/85A AU568033B2 (en) 1980-09-25 1985-11-13 3-((1,2,4-triazolyl or 2 (1,2,3,4-tetrazolyl) methyl) cephalosporins
SE8600192A SE468478B (en) 1980-09-25 1986-01-16 NEW CEPHALOSPORIN DERIVATIVES WHICH ARE APPLICABLE AS INTERMEDIATE
SE8600195A SE468477B (en) 1980-09-25 1986-01-16 PROCEDURES FOR THE PREPARATION OF 7-AMINO-3-SUBSTITUTED CEPHALOSPORIC ACID
SE8600193A SE468479B (en) 1980-09-25 1986-01-16 NEW CEPHALOSPORIN DERIVATIVES WHICH ARE APPLICABLE AS INTERMEDIATE
SE8600194A SE468476B (en) 1980-09-25 1986-01-16 NEW 7- (SUBSTITUTED OR UNSUBSTITUTED AMINO) -3- SUBSTITUTED METHYL-CEFEM-4-CARBOXYL ACID
KR1019860002383A KR860000932B1 (en) 1980-09-25 1986-03-29 Process of preparing cephalosporanic acid derivatives
FI870153A FI80041C (en) 1980-09-25 1987-01-15 PROCEDURE FOR FRAMSTAELLNING AV 7-AMINO-3- (SUBSTITUTED METHYL) -3-CEFEM-4-CARBOXYLSYROR.
US07/022,433 US4879381A (en) 1980-09-25 1987-03-06 7-(substituted or unsubstituted amino) 3-substituted methyl-3 cephem-4-carboxylic acid
US07/707,221 US5144027A (en) 1980-09-25 1991-05-24 Cephalosporins, process for producing the same, intermediates thereof and process for producing the intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55175263A JPS6052755B2 (en) 1980-12-13 1980-12-13 New cephalosporins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP56178293A Division JPS6053036B2 (en) 1981-11-09 1981-11-09 New cephalosporins

Publications (2)

Publication Number Publication Date
JPS5799592A true JPS5799592A (en) 1982-06-21
JPS6052755B2 JPS6052755B2 (en) 1985-11-21

Family

ID=15993092

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55175263A Expired JPS6052755B2 (en) 1980-09-25 1980-12-13 New cephalosporins

Country Status (5)

Country Link
JP (1) JPS6052755B2 (en)
CS (3) CS236492B2 (en)
IL (2) IL74413A (en)
PL (2) PL135446B1 (en)
SU (4) SU1190987A3 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604189A (en) * 1983-06-20 1985-01-10 Sankyo Co Ltd Production of beta-lactam compound
JPS60228486A (en) * 1984-04-26 1985-11-13 Toyama Chem Co Ltd Novel process for preparing cephalosporin
JPS6137788A (en) * 1984-07-31 1986-02-22 Taito Pfizer Kk Novel cephalosporin compound
JPS6251688A (en) * 1985-08-30 1987-03-06 Taito Pfizer Kk Novel cephalosporin compound
JPS6267089A (en) * 1985-09-20 1987-03-26 Toyama Chem Co Ltd Purification of cephalosporin
EP0238060A2 (en) 1986-03-19 1987-09-23 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6872646B2 (en) 2017-09-14 2021-05-19 アップル インコーポレイテッドＡｐｐｌｅ Ｉｎｃ． Face sticker for head-mounted display

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604189A (en) * 1983-06-20 1985-01-10 Sankyo Co Ltd Production of beta-lactam compound
JPH0332554B2 (en) * 1983-06-20 1991-05-13 Sankyo Co
JPS60228486A (en) * 1984-04-26 1985-11-13 Toyama Chem Co Ltd Novel process for preparing cephalosporin
JPS6137788A (en) * 1984-07-31 1986-02-22 Taito Pfizer Kk Novel cephalosporin compound
JPS6251688A (en) * 1985-08-30 1987-03-06 Taito Pfizer Kk Novel cephalosporin compound
JPS6267089A (en) * 1985-09-20 1987-03-26 Toyama Chem Co Ltd Purification of cephalosporin
EP0238060A2 (en) 1986-03-19 1987-09-23 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents

Also Published As

Publication number Publication date
CS236491B2 (en) 1985-05-15
SU1418329A1 (en) 1988-08-23
PL238230A1 (en) 1983-05-23
SU1274625A3 (en) 1986-11-30
SU1249017A1 (en) 1986-08-07
PL135611B1 (en) 1985-11-30
PL233143A1 (en) 1983-05-23
CS236471B2 (en) 1985-05-15
IL74413A (en) 1986-08-31
IL74413A0 (en) 1985-05-31
CS236492B2 (en) 1985-05-15
PL135446B1 (en) 1985-10-31
JPS6052755B2 (en) 1985-11-21
SU1190987A3 (en) 1985-11-07

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Legal Events

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EXPY Cancellation because of completion of term