JPS5686188A - 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation - Google Patents

7-acylamino-3-substituted cephalosporanic acid derivative and its preparation

Info

Publication number
JPS5686188A
JPS5686188A JP16399080A JP16399080A JPS5686188A JP S5686188 A JPS5686188 A JP S5686188A JP 16399080 A JP16399080 A JP 16399080A JP 16399080 A JP16399080 A JP 16399080A JP S5686188 A JPS5686188 A JP S5686188A
Authority
JP
Japan
Prior art keywords
formula
compound
salt
acylamino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16399080A
Other languages
Japanese (ja)
Inventor
Takao Takatani
Hisashi Takasugi
Takashi Masugi
Hideaki Yamanaka
Koji Kawabata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS5686188A publication Critical patent/JPS5686188A/en
Pending legal-status Critical Current

Links

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

NEW MATERIAL:A compound of formula I [R1 is group of formula II (R4 is lower alkyl), etc.; R2 is lower alkoxymethyl, lower alkylthiomethyl, etc.; R3 is carboxy or protected carboxy; A is lower alkylene which may be substituted by amino, OH, oxo, etc.] or a salt thereof.
EXAMPLE: 7-[ 2- ( 2-Aminothiazol-4-yl ) -2-methoxyiminoacetamido ]-3-methylthiomethyl-3-cephem-4-carboxylic acid.
USE: An antimicrobial agent, particularly a drug for oral administration, capable of inhibiting the growth of various pathogenic microorganisms including both gram- positive and gram-negative bacteria.
PROCESS: A compound of formula III, a reactive derivative or a salt thereof is reacted with a compound of the formula R1-A-COOH, a reactive derivative or a salt thereof to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP16399080A 1979-11-19 1980-11-19 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation Pending JPS5686188A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7939985 1979-11-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP19117582A Division JPS5896092A (en) 1979-11-19 1982-10-29 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5686188A true JPS5686188A (en) 1981-07-13

Family

ID=10509300

Family Applications (12)

Application Number Title Priority Date Filing Date
JP16398980A Granted JPS5686187A (en) 1979-11-19 1980-11-19 7-acylamino-3-vinylcephalosporanic acid derivative and its preparation
JP16399080A Pending JPS5686188A (en) 1979-11-19 1980-11-19 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation
JP19117582A Granted JPS5896092A (en) 1979-11-19 1982-10-29 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation
JP22640283A Granted JPS59144788A (en) 1979-11-19 1983-11-29 7-acyalmino-3-substituted cephalosporanic acid derivative and preparation thereof
JP27813884A Pending JPS60185787A (en) 1979-11-19 1984-12-29 7-acylamino-3-substituted-cephalosporanic acid derivative and preparation thereof
JP62044400A Granted JPS62277391A (en) 1979-11-19 1987-02-26 7-acylamino-3-vinylcephalosporanic acid derivative and production thereof
JP62290251A Granted JPS63152370A (en) 1979-11-19 1987-11-17 Novel carboxylic acid
JP62290253A Granted JPS63146863A (en) 1979-11-19 1987-11-17 Carboxylic acids
JP29025087A Granted JPS63152385A (en) 1979-11-19 1987-11-17 Novel 7-substituted-3-vinylcephalosporanic acid
JP62290252A Granted JPS63152371A (en) 1979-11-19 1987-11-17 Aminothiazole derivative
JP29024987A Granted JPS63152388A (en) 1979-11-19 1987-11-17 Novel cephem compound
JP29024887A Granted JPS63152387A (en) 1979-11-19 1987-11-17 7-acylamino-3-vinyl cephalosporanic acid derivative

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP16398980A Granted JPS5686187A (en) 1979-11-19 1980-11-19 7-acylamino-3-vinylcephalosporanic acid derivative and its preparation

Family Applications After (10)

Application Number Title Priority Date Filing Date
JP19117582A Granted JPS5896092A (en) 1979-11-19 1982-10-29 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation
JP22640283A Granted JPS59144788A (en) 1979-11-19 1983-11-29 7-acyalmino-3-substituted cephalosporanic acid derivative and preparation thereof
JP27813884A Pending JPS60185787A (en) 1979-11-19 1984-12-29 7-acylamino-3-substituted-cephalosporanic acid derivative and preparation thereof
JP62044400A Granted JPS62277391A (en) 1979-11-19 1987-02-26 7-acylamino-3-vinylcephalosporanic acid derivative and production thereof
JP62290251A Granted JPS63152370A (en) 1979-11-19 1987-11-17 Novel carboxylic acid
JP62290253A Granted JPS63146863A (en) 1979-11-19 1987-11-17 Carboxylic acids
JP29025087A Granted JPS63152385A (en) 1979-11-19 1987-11-17 Novel 7-substituted-3-vinylcephalosporanic acid
JP62290252A Granted JPS63152371A (en) 1979-11-19 1987-11-17 Aminothiazole derivative
JP29024987A Granted JPS63152388A (en) 1979-11-19 1987-11-17 Novel cephem compound
JP29024887A Granted JPS63152387A (en) 1979-11-19 1987-11-17 7-acylamino-3-vinyl cephalosporanic acid derivative

Country Status (2)

Country Link
JP (12) JPS5686187A (en)
ZA (1) ZA806977B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128786A (en) * 1980-02-18 1981-10-08 Roussel Uclaf Novel oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamidocephalosporanic acid, their manufacture, their use as drug, drug containing them and novel intermediate
WO1984004747A1 (en) * 1983-03-02 1984-12-06 Kyoto Pharma Ind Cephem compounds

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464369A (en) * 1977-03-14 1984-08-07 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
EP0156118A1 (en) * 1980-08-29 1985-10-02 Fujisawa Pharmaceutical Co., Ltd. New starting compounds for the preparation of cephem compounds and processes for preparation thereof
JPS6052754B2 (en) * 1981-01-29 1985-11-21 山之内製薬株式会社 7-amino-3-halogenomethyl-△↑3-cephem-4-carboxylic acids and their production method
JPS58135894A (en) * 1982-01-22 1983-08-12 Fujisawa Pharmaceut Co Ltd 7-acylamino-3-vinylcephalosporanic acid derivative and its preparation
JPS5921695A (en) * 1982-07-29 1984-02-03 Dai Ichi Seiyaku Co Ltd Cephalosporin derivative
DK162718C (en) * 1982-09-30 1992-05-11 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING 7-SUBSTITUTED-3-VINYL-3-CEPHEM COMPOUNDS
ZA836918B (en) * 1982-09-30 1984-05-30 Fujisawa Pharmaceutical Co 7-substituted-3-vinyl-3-cephem compounds and processes for the production of the same
JPS59210092A (en) * 1983-05-13 1984-11-28 Dai Ichi Seiyaku Co Ltd Cephalosporin derivative
GB8318846D0 (en) * 1983-07-12 1983-08-10 Fujisawa Pharmaceutical Co Prophylactic/therapeutic agent against fish diseases
GB8329030D0 (en) * 1983-10-31 1983-11-30 Fujisawa Pharmaceutical Co Cephem compounds
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
CA1283404C (en) * 1986-07-01 1991-04-23 Shigeru Sanai Cephalosporin compounds, processes for their preparation and antibacterial agents
JP4157177B2 (en) * 1997-06-04 2008-09-24 大塚化学ホールディングス株式会社 Method for producing 3-alkenylcephem compound
AT406773B (en) * 1998-04-02 2000-08-25 Biochemie Gmbh NEW SALT OF 7- (2- (AMINOTHIAZOL-4YL) -2-
ITMI20022076A1 (en) * 2002-10-01 2004-04-02 Antibioticos Spa INTERMEDIATE SALTS OF CEFDINIR.
US7980324B2 (en) 2006-02-03 2011-07-19 Black & Decker Inc. Housing and gearbox for drill or driver
JP4779741B2 (en) * 2006-03-22 2011-09-28 株式会社日立製作所 Heat pump system, shaft sealing method of heat pump system, modification method of heat pump system
UY34585A (en) * 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg B-LACTAMIC COMPOUNDS REPLACED WITH AMIDINE, ITS PREPARATION AND USE
KR101485316B1 (en) * 2014-04-16 2015-01-22 (주)에이치티씨 Automatic crimping device of flat cable connector pins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1325846A (en) * 1972-02-23 1973-08-08 Lilly Co Eli Process for the preparation of a 3-thiomethyl cephalosporin
DE2209019A1 (en) * 1972-02-25 1973-08-30 Lilly Co Eli 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa
JPS50100076A (en) * 1974-01-14 1975-08-08

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789817A (en) * 1971-10-07 1973-04-06 Glaxo Lab Ltd IMPROVEMENTS WITH CEPHALOSPORIN COMPOUNDS
DE2710902A1 (en) * 1977-03-12 1978-09-21 Hoechst Ag CEPHEM DERIVATIVES AND METHOD FOR THEIR PRODUCTION
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
FR2432521A1 (en) * 1978-03-31 1980-02-29 Roussel Uclaf NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
GB2058791B (en) * 1978-05-26 1982-11-24 Glaxo Group Ltd Cephalosporin antibiotics
GB1604723A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-aminothiazol-4-yl)-2-oxyimino-acetamido)-cephem derivatives
JPS5559197A (en) * 1978-10-27 1980-05-02 Glaxo Group Ltd Novel cephalosporin compound
JPS5559196A (en) * 1978-10-27 1980-05-02 Glaxo Group Ltd Cephalosporin compound
BE880037A (en) * 1978-11-15 1980-05-14 Glaxo Group Ltd CEPHALOSPORINS WITH ANTIBIOTIC ACTIVITY AND PREPARATION METHOD
JPS5589289A (en) * 1978-11-17 1980-07-05 Glaxo Group Ltd Cephalosporin antibiotic
JPS55115888A (en) * 1979-02-23 1980-09-06 Glaxo Group Ltd Cephalosporin antibiotic
JPS55124790A (en) * 1979-03-19 1980-09-26 Sankyo Co Ltd Cephem compound, its preparation and antimicrobials consisting the same mainly
NL160860B (en) * 1979-03-22 American Cyanamid Co PROCEDURE FOR PREPARING A VULCANIZABLE MIXTURE.
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1325846A (en) * 1972-02-23 1973-08-08 Lilly Co Eli Process for the preparation of a 3-thiomethyl cephalosporin
DE2209019A1 (en) * 1972-02-25 1973-08-30 Lilly Co Eli 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa
JPS50100076A (en) * 1974-01-14 1975-08-08

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128786A (en) * 1980-02-18 1981-10-08 Roussel Uclaf Novel oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamidocephalosporanic acid, their manufacture, their use as drug, drug containing them and novel intermediate
JPS58170789A (en) * 1980-02-18 1983-10-07 ルセル−ユクラフ Novel oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamido cephalosporanic acid, manufacture , use as drug, drug containing them and novel intermediate
JPS6452784A (en) * 1980-02-18 1989-02-28 Roussel Uclaf Novel oxime derivative of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamido cephalosporanic acid
JPH0143757B2 (en) * 1980-02-18 1989-09-22 Roussel Uclaf
JPH0639476B2 (en) * 1980-02-18 1994-05-25 ルセル−ユクラフ Novel 3-oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamide cefalosporanic acid
WO1984004747A1 (en) * 1983-03-02 1984-12-06 Kyoto Pharma Ind Cephem compounds

Also Published As

Publication number Publication date
JPH0225905B2 (en) 1990-06-06
JPH0338277B2 (en) 1991-06-10
JPS63152387A (en) 1988-06-24
JPS63146863A (en) 1988-06-18
JPH0333712B2 (en) 1991-05-20
JPS63152385A (en) 1988-06-24
JPS59144788A (en) 1984-08-18
JPH0338278B2 (en) 1991-06-10
ZA806977B (en) 1981-10-28
JPS63152370A (en) 1988-06-24
JPH0215556B2 (en) 1990-04-12
JPS63152371A (en) 1988-06-24
JPS5686187A (en) 1981-07-13
JPS6320435B2 (en) 1988-04-27
JPH0369353B2 (en) 1991-10-31
JPS6238357B2 (en) 1987-08-17
JPH0219828B2 (en) 1990-05-07
JPS63152388A (en) 1988-06-24
JPS62277391A (en) 1987-12-02
JPH0314832B2 (en) 1991-02-27
JPS60185787A (en) 1985-09-21
JPS5896092A (en) 1983-06-07

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