JPS55105689A - Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism - Google Patents

Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism

Info

Publication number
JPS55105689A
JPS55105689A JP17254779A JP17254779A JPS55105689A JP S55105689 A JPS55105689 A JP S55105689A JP 17254779 A JP17254779 A JP 17254779A JP 17254779 A JP17254779 A JP 17254779A JP S55105689 A JPS55105689 A JP S55105689A
Authority
JP
Japan
Prior art keywords
formula
preparation
amino
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17254779A
Other languages
Japanese (ja)
Other versions
JPH0240677B2 (en
Inventor
Tsutomu Terachi
Kazuo Sakane
Jiro Goto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS55105689A publication Critical patent/JPS55105689A/en
Priority claimed from AU23283/84A external-priority patent/AU2328384A/en
Publication of JPH0240677B2 publication Critical patent/JPH0240677B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

NEW MATERIAL:Compounds of formula I [R1 is amino, protected amino; R2 is H, acyl, aryl, lower alkyl, alkenyl, cycloalkyl,; R3 is H, lower alkyl; R4 is H, acyloxy (lower)alkyl, pyridinium(lower)alkyl; R5 is carboxy, pretected carboxy; the thick line is single or double bonds].
EXAMPLE: 7-[ 2-cyclopentyloxyimino-2-( 5-amino-1,2,4-thiadiazol-3-yl )acetamide ]- 3-cephem-4-carboxylic acid (syn-isomer).
USE: Antibacterial or its intermediate: they are effective on gram-positive and -negative bacteria.
PREPARATION: A compound of formula II or its reactive derivative in the amino group is made to react with a compound of formula III or its reactive derivative to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP17254779A 1978-12-29 1979-12-28 Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism Granted JPS55105689A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7850334 1978-12-29
AU23283/84A AU2328384A (en) 1978-12-29 1984-01-13 1,2,4-thiadiazole derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005450A Division JPH02223572A (en) 1978-12-19 1990-01-12 Thiadiazoleactic acid derivative

Publications (2)

Publication Number Publication Date
JPS55105689A true JPS55105689A (en) 1980-08-13
JPH0240677B2 JPH0240677B2 (en) 1990-09-12

Family

ID=32962948

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17254779A Granted JPS55105689A (en) 1978-12-29 1979-12-28 Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism

Country Status (2)

Country Link
JP (1) JPS55105689A (en)
HU (1) HU183006B (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5724389A (en) * 1980-06-18 1982-02-08 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation, and preventive and remedy for bacteriosis
JPS5777689A (en) * 1980-09-08 1982-05-15 Fujisawa Pharmaceut Co Ltd Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient
JPS5781493A (en) * 1980-09-12 1982-05-21 Ciba Geigy Ag Ammoniomethyl compound, manufacture and medicinal composition containing same
JPS57158769A (en) * 1981-03-06 1982-09-30 Fujisawa Pharmaceut Co Ltd Preparation of 2-substituted hydroxyimino-2-(5-amino-1,2,4- thiadiazol-3-yl)acetic acid or its salt, and their intermediate
JPS584789A (en) * 1981-04-03 1983-01-11 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation, preventive and remedy for microbism
JPS5810589A (en) * 1981-06-22 1983-01-21 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation and preventing agent and remedy for microbism
JPS5841887A (en) * 1981-08-19 1983-03-11 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation and preventive or remedy for microbism
JPS5859992A (en) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd Novel cephen compound, its preparation and preventing agent and remedy for microbism
JPS5888386A (en) * 1981-10-22 1983-05-26 Fujisawa Pharmaceut Co Ltd Cephem compound and its preparation
JPS58126877A (en) * 1982-01-05 1983-07-28 Fujisawa Pharmaceut Co Ltd Azetidinone compound or its salt and their preparation
JPS59130293A (en) * 1983-01-04 1984-07-26 Fujisawa Pharmaceut Co Ltd Novel cephem compound and its preparation
JPS59130878A (en) * 1983-01-11 1984-07-27 バイエル・アクチエンゲゼルシヤフト Novel cephalosporins and manufacture
JPS61243090A (en) * 1985-04-09 1986-10-29 Fujisawa Pharmaceut Co Ltd Novel cephem compound and salt thereof
JPS62286991A (en) * 1986-06-05 1987-12-12 Fujisawa Pharmaceut Co Ltd Cephalosporanic acid derivative or its salt permissible as pharmaceutical
JPH01156984A (en) * 1986-11-06 1989-06-20 Eisai Co Ltd 3-propenylcephem derivative
JPH0276865A (en) * 1981-09-14 1990-03-16 Fujisawa Pharmaceut Co Ltd Production of thiadiazolylacetic same compound
JPH02218685A (en) * 1981-04-03 1990-08-31 Fujisawa Pharmaceut Co Ltd New cephem compound, production thereof and preventive-curing agent of microbism

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3202763B1 (en) * 2014-10-02 2017-12-13 Fujifilm Corporation Method for producing 5-amino-3 substituted-1,2,4-thiadiazole

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4727991U (en) * 1971-04-15 1972-11-29
JPS484487U (en) * 1971-06-15 1973-01-19
JPS5353691A (en) * 1976-10-08 1978-05-16 Fujisawa Pharmaceut Co Ltd 3,7-di-substituted-3-cephem-4 carboxylic acid derivatives, their salts andtheir preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4727991U (en) * 1971-04-15 1972-11-29
JPS484487U (en) * 1971-06-15 1973-01-19
JPS5353691A (en) * 1976-10-08 1978-05-16 Fujisawa Pharmaceut Co Ltd 3,7-di-substituted-3-cephem-4 carboxylic acid derivatives, their salts andtheir preparation

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5724389A (en) * 1980-06-18 1982-02-08 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation, and preventive and remedy for bacteriosis
JPH031314B2 (en) * 1980-06-18 1991-01-10 Fujisawa Pharmaceutical Co
JPS5777689A (en) * 1980-09-08 1982-05-15 Fujisawa Pharmaceut Co Ltd Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient
JPH0158191B2 (en) * 1980-09-08 1989-12-11 Fujisawa Pharmaceutical Co
JPS5781493A (en) * 1980-09-12 1982-05-21 Ciba Geigy Ag Ammoniomethyl compound, manufacture and medicinal composition containing same
JPS57158769A (en) * 1981-03-06 1982-09-30 Fujisawa Pharmaceut Co Ltd Preparation of 2-substituted hydroxyimino-2-(5-amino-1,2,4- thiadiazol-3-yl)acetic acid or its salt, and their intermediate
JPH0476990B2 (en) * 1981-03-06 1992-12-07 Fujisawa Pharmaceutical Co
JPH0524159B2 (en) * 1981-04-03 1993-04-06 Fujisawa Pharmaceutical Co
JPS584789A (en) * 1981-04-03 1983-01-11 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation, preventive and remedy for microbism
JPH0261479B2 (en) * 1981-04-03 1990-12-20 Fujisawa Pharmaceutical Co
JPH02218685A (en) * 1981-04-03 1990-08-31 Fujisawa Pharmaceut Co Ltd New cephem compound, production thereof and preventive-curing agent of microbism
JPS5810589A (en) * 1981-06-22 1983-01-21 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation and preventing agent and remedy for microbism
JPH0359076B2 (en) * 1981-06-22 1991-09-09 Fujisawa Pharmaceutical Co
JPS5841887A (en) * 1981-08-19 1983-03-11 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation and preventive or remedy for microbism
JPH0453868B2 (en) * 1981-08-19 1992-08-27 Fujisawa Pharmaceutical Co
JPH0526795B2 (en) * 1981-09-14 1993-04-19 Fujisawa Pharmaceutical Co
JPH0276865A (en) * 1981-09-14 1990-03-16 Fujisawa Pharmaceut Co Ltd Production of thiadiazolylacetic same compound
JPS5859992A (en) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd Novel cephen compound, its preparation and preventing agent and remedy for microbism
JPH05392B2 (en) * 1981-09-14 1993-01-05 Fujisawa Pharmaceutical Co
JPS5888386A (en) * 1981-10-22 1983-05-26 Fujisawa Pharmaceut Co Ltd Cephem compound and its preparation
JPH0357904B2 (en) * 1982-01-05 1991-09-03 Fujisawa Pharmaceutical Co
JPS58126877A (en) * 1982-01-05 1983-07-28 Fujisawa Pharmaceut Co Ltd Azetidinone compound or its salt and their preparation
JPS59130293A (en) * 1983-01-04 1984-07-26 Fujisawa Pharmaceut Co Ltd Novel cephem compound and its preparation
JPS59130878A (en) * 1983-01-11 1984-07-27 バイエル・アクチエンゲゼルシヤフト Novel cephalosporins and manufacture
JPS61243090A (en) * 1985-04-09 1986-10-29 Fujisawa Pharmaceut Co Ltd Novel cephem compound and salt thereof
JPS62286991A (en) * 1986-06-05 1987-12-12 Fujisawa Pharmaceut Co Ltd Cephalosporanic acid derivative or its salt permissible as pharmaceutical
JPH01156984A (en) * 1986-11-06 1989-06-20 Eisai Co Ltd 3-propenylcephem derivative

Also Published As

Publication number Publication date
HU183006B (en) 1984-04-28
JPH0240677B2 (en) 1990-09-12

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