JPS55105689A - Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism - Google Patents
Novel cephem and cepham compounds, their preparation and preventive and remedy for microbismInfo
- Publication number
- JPS55105689A JPS55105689A JP17254779A JP17254779A JPS55105689A JP S55105689 A JPS55105689 A JP S55105689A JP 17254779 A JP17254779 A JP 17254779A JP 17254779 A JP17254779 A JP 17254779A JP S55105689 A JPS55105689 A JP S55105689A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- amino
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
NEW MATERIAL:Compounds of formula I [R1 is amino, protected amino; R2 is H, acyl, aryl, lower alkyl, alkenyl, cycloalkyl,; R3 is H, lower alkyl; R4 is H, acyloxy (lower)alkyl, pyridinium(lower)alkyl; R5 is carboxy, pretected carboxy; the thick line is single or double bonds].
EXAMPLE: 7-[ 2-cyclopentyloxyimino-2-( 5-amino-1,2,4-thiadiazol-3-yl )acetamide ]- 3-cephem-4-carboxylic acid (syn-isomer).
USE: Antibacterial or its intermediate: they are effective on gram-positive and -negative bacteria.
PREPARATION: A compound of formula II or its reactive derivative in the amino group is made to react with a compound of formula III or its reactive derivative to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7850334 | 1978-12-29 | ||
AU23283/84A AU2328384A (en) | 1978-12-29 | 1984-01-13 | 1,2,4-thiadiazole derivatives |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005450A Division JPH02223572A (en) | 1978-12-19 | 1990-01-12 | Thiadiazoleactic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55105689A true JPS55105689A (en) | 1980-08-13 |
JPH0240677B2 JPH0240677B2 (en) | 1990-09-12 |
Family
ID=32962948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17254779A Granted JPS55105689A (en) | 1978-12-29 | 1979-12-28 | Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS55105689A (en) |
HU (1) | HU183006B (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5724389A (en) * | 1980-06-18 | 1982-02-08 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation, and preventive and remedy for bacteriosis |
JPS5777689A (en) * | 1980-09-08 | 1982-05-15 | Fujisawa Pharmaceut Co Ltd | Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient |
JPS5781493A (en) * | 1980-09-12 | 1982-05-21 | Ciba Geigy Ag | Ammoniomethyl compound, manufacture and medicinal composition containing same |
JPS57158769A (en) * | 1981-03-06 | 1982-09-30 | Fujisawa Pharmaceut Co Ltd | Preparation of 2-substituted hydroxyimino-2-(5-amino-1,2,4- thiadiazol-3-yl)acetic acid or its salt, and their intermediate |
JPS584789A (en) * | 1981-04-03 | 1983-01-11 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation, preventive and remedy for microbism |
JPS5810589A (en) * | 1981-06-22 | 1983-01-21 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation and preventing agent and remedy for microbism |
JPS5841887A (en) * | 1981-08-19 | 1983-03-11 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation and preventive or remedy for microbism |
JPS5859992A (en) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | Novel cephen compound, its preparation and preventing agent and remedy for microbism |
JPS5888386A (en) * | 1981-10-22 | 1983-05-26 | Fujisawa Pharmaceut Co Ltd | Cephem compound and its preparation |
JPS58126877A (en) * | 1982-01-05 | 1983-07-28 | Fujisawa Pharmaceut Co Ltd | Azetidinone compound or its salt and their preparation |
JPS59130293A (en) * | 1983-01-04 | 1984-07-26 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound and its preparation |
JPS59130878A (en) * | 1983-01-11 | 1984-07-27 | バイエル・アクチエンゲゼルシヤフト | Novel cephalosporins and manufacture |
JPS61243090A (en) * | 1985-04-09 | 1986-10-29 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound and salt thereof |
JPS62286991A (en) * | 1986-06-05 | 1987-12-12 | Fujisawa Pharmaceut Co Ltd | Cephalosporanic acid derivative or its salt permissible as pharmaceutical |
JPH01156984A (en) * | 1986-11-06 | 1989-06-20 | Eisai Co Ltd | 3-propenylcephem derivative |
JPH0276865A (en) * | 1981-09-14 | 1990-03-16 | Fujisawa Pharmaceut Co Ltd | Production of thiadiazolylacetic same compound |
JPH02218685A (en) * | 1981-04-03 | 1990-08-31 | Fujisawa Pharmaceut Co Ltd | New cephem compound, production thereof and preventive-curing agent of microbism |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3202763B1 (en) * | 2014-10-02 | 2017-12-13 | Fujifilm Corporation | Method for producing 5-amino-3 substituted-1,2,4-thiadiazole |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4727991U (en) * | 1971-04-15 | 1972-11-29 | ||
JPS484487U (en) * | 1971-06-15 | 1973-01-19 | ||
JPS5353691A (en) * | 1976-10-08 | 1978-05-16 | Fujisawa Pharmaceut Co Ltd | 3,7-di-substituted-3-cephem-4 carboxylic acid derivatives, their salts andtheir preparation |
-
1979
- 1979-12-28 HU HU79FU382A patent/HU183006B/en unknown
- 1979-12-28 JP JP17254779A patent/JPS55105689A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4727991U (en) * | 1971-04-15 | 1972-11-29 | ||
JPS484487U (en) * | 1971-06-15 | 1973-01-19 | ||
JPS5353691A (en) * | 1976-10-08 | 1978-05-16 | Fujisawa Pharmaceut Co Ltd | 3,7-di-substituted-3-cephem-4 carboxylic acid derivatives, their salts andtheir preparation |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5724389A (en) * | 1980-06-18 | 1982-02-08 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation, and preventive and remedy for bacteriosis |
JPH031314B2 (en) * | 1980-06-18 | 1991-01-10 | Fujisawa Pharmaceutical Co | |
JPS5777689A (en) * | 1980-09-08 | 1982-05-15 | Fujisawa Pharmaceut Co Ltd | Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient |
JPH0158191B2 (en) * | 1980-09-08 | 1989-12-11 | Fujisawa Pharmaceutical Co | |
JPS5781493A (en) * | 1980-09-12 | 1982-05-21 | Ciba Geigy Ag | Ammoniomethyl compound, manufacture and medicinal composition containing same |
JPS57158769A (en) * | 1981-03-06 | 1982-09-30 | Fujisawa Pharmaceut Co Ltd | Preparation of 2-substituted hydroxyimino-2-(5-amino-1,2,4- thiadiazol-3-yl)acetic acid or its salt, and their intermediate |
JPH0476990B2 (en) * | 1981-03-06 | 1992-12-07 | Fujisawa Pharmaceutical Co | |
JPH0524159B2 (en) * | 1981-04-03 | 1993-04-06 | Fujisawa Pharmaceutical Co | |
JPS584789A (en) * | 1981-04-03 | 1983-01-11 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation, preventive and remedy for microbism |
JPH0261479B2 (en) * | 1981-04-03 | 1990-12-20 | Fujisawa Pharmaceutical Co | |
JPH02218685A (en) * | 1981-04-03 | 1990-08-31 | Fujisawa Pharmaceut Co Ltd | New cephem compound, production thereof and preventive-curing agent of microbism |
JPS5810589A (en) * | 1981-06-22 | 1983-01-21 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation and preventing agent and remedy for microbism |
JPH0359076B2 (en) * | 1981-06-22 | 1991-09-09 | Fujisawa Pharmaceutical Co | |
JPS5841887A (en) * | 1981-08-19 | 1983-03-11 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound, its preparation and preventive or remedy for microbism |
JPH0453868B2 (en) * | 1981-08-19 | 1992-08-27 | Fujisawa Pharmaceutical Co | |
JPH0526795B2 (en) * | 1981-09-14 | 1993-04-19 | Fujisawa Pharmaceutical Co | |
JPH0276865A (en) * | 1981-09-14 | 1990-03-16 | Fujisawa Pharmaceut Co Ltd | Production of thiadiazolylacetic same compound |
JPS5859992A (en) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | Novel cephen compound, its preparation and preventing agent and remedy for microbism |
JPH05392B2 (en) * | 1981-09-14 | 1993-01-05 | Fujisawa Pharmaceutical Co | |
JPS5888386A (en) * | 1981-10-22 | 1983-05-26 | Fujisawa Pharmaceut Co Ltd | Cephem compound and its preparation |
JPH0357904B2 (en) * | 1982-01-05 | 1991-09-03 | Fujisawa Pharmaceutical Co | |
JPS58126877A (en) * | 1982-01-05 | 1983-07-28 | Fujisawa Pharmaceut Co Ltd | Azetidinone compound or its salt and their preparation |
JPS59130293A (en) * | 1983-01-04 | 1984-07-26 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound and its preparation |
JPS59130878A (en) * | 1983-01-11 | 1984-07-27 | バイエル・アクチエンゲゼルシヤフト | Novel cephalosporins and manufacture |
JPS61243090A (en) * | 1985-04-09 | 1986-10-29 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound and salt thereof |
JPS62286991A (en) * | 1986-06-05 | 1987-12-12 | Fujisawa Pharmaceut Co Ltd | Cephalosporanic acid derivative or its salt permissible as pharmaceutical |
JPH01156984A (en) * | 1986-11-06 | 1989-06-20 | Eisai Co Ltd | 3-propenylcephem derivative |
Also Published As
Publication number | Publication date |
---|---|
HU183006B (en) | 1984-04-28 |
JPH0240677B2 (en) | 1990-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55105689A (en) | Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism | |
JPS5520800A (en) | Cephem compounds, their salts, their preparation, and preventive or remedy for microbism containing the same as the effective component | |
JPS5686188A (en) | 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation | |
JPS5452096A (en) | Cephem compound, its preparation and bacteriostatic agent containing the same | |
JPS5492987A (en) | Cephalosporanic acid derivative, its salt, or their preparation, and preventives and remedies for microbisms consisting mainly of them | |
JPS56125392A (en) | Cepham and cephem compound and preparation thereof | |
JPS5547688A (en) | Novel cephem compound and its preparation | |
JPS57112396A (en) | Novel cephem compound, its preparation and prophylactic or remedy for microbism | |
JPS5798288A (en) | Novel cephem compound or its salt, their preparation, and preventive and remedy for bacteriosis containing said compound as active component | |
JPS5535096A (en) | 3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent | |
JPS54117493A (en) | 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, its preparation, and preventives and remedies for microbism consisting mainly of them | |
JPS5799592A (en) | Novel cephalosporins | |
JPS5643288A (en) | Cephalosporin derivative and its preparation | |
JPS5511600A (en) | Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same | |
ES8200371A1 (en) | N-substituted thiazolyl derivatives of oxy-imino-substituted cephalosporins useful as anti-bacterial agents | |
JPS5547690A (en) | Cephem compound, its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents | |
JPS55124790A (en) | Cephem compound, its preparation and antimicrobials consisting the same mainly | |
JPS5549384A (en) | Novel antibacterial compound | |
JPS54117494A (en) | Cephalosporin compound and its preparation | |
JPS5649389A (en) | Novel cephem compound, its preparation, and preventive and remedy for microbism | |
JPS55149288A (en) | Cephalosporanic acid derivative having pyrimidine or its salt | |
JPS5649387A (en) | Novel cephem compound, its preparation, and remedy and preventive for microbism | |
JPS56131591A (en) | 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent | |
JPS55164690A (en) | 7- 2- 2-aminothiazole-4-yl 3-hydroxypropionamide cephalosporin compound and its preparation | |
JPS5745190A (en) | Novel 7alpha-methoxycephalosporin |