JPS5772987A - Production of cephalosporanic acid derivative - Google Patents

Production of cephalosporanic acid derivative

Info

Publication number
JPS5772987A
JPS5772987A JP14685980A JP14685980A JPS5772987A JP S5772987 A JPS5772987 A JP S5772987A JP 14685980 A JP14685980 A JP 14685980A JP 14685980 A JP14685980 A JP 14685980A JP S5772987 A JPS5772987 A JP S5772987A
Authority
JP
Japan
Prior art keywords
formula
acid
acid derivative
compound
acylations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14685980A
Other languages
Japanese (ja)
Inventor
Masahiro Murakami
Masateru Kobayashi
Kimiyo Yamamoto
Kazuyuki Shibuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP14685980A priority Critical patent/JPS5772987A/en
Priority to AT84109690T priority patent/ATE31416T1/en
Priority to DE8484109690T priority patent/DE3176575D1/en
Priority to EP84109690A priority patent/EP0137227B1/en
Priority to DE8181106833T priority patent/DE3173499D1/en
Priority to EP81106833A priority patent/EP0047014B1/en
Priority to US06/298,884 priority patent/US4463179A/en
Publication of JPS5772987A publication Critical patent/JPS5772987A/en
Priority to US06/414,946 priority patent/US4456754A/en
Priority to US06/545,202 priority patent/US4454323A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To reaction between 7-aminocephalosporanic acid derivative and a novel active thioester affords a cephalosporanic acid derivative used as an antibiotic with a very wide range of antibiotic spectrum with high safety in high yield.
CONSTITUTION: The reaction of 7-aminocephalosporanic acid derivative of formula I(R1 is halogen, azide, acetoxy) or its salt with with a 1-methyl-tetrazol-5-ylthiol ester of formula II (R2 is trifuoromethylthioacetic acid) gives the objective compound of formula III. A new compound of thioester of formula II has a almost the same level of reactivity as an acid chloride or mixed acid anyhdride, which are said to be highest reactive in acylations and effects acylations not only in the 7-position but also in the 3-position. The compound of formula II is obtained from a compound of formula IV and 2-trifluoromethylacetic acid in high yield.
COPYRIGHT: (C)1982,JPO&Japio
JP14685980A 1980-09-02 1980-10-22 Production of cephalosporanic acid derivative Pending JPS5772987A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP14685980A JPS5772987A (en) 1980-10-22 1980-10-22 Production of cephalosporanic acid derivative
AT84109690T ATE31416T1 (en) 1980-09-02 1981-09-01 PROCESS FOR THE PRODUCTION OF CEPHALOSPORIN DERIVATIVES USING NEW THIOESTERS.
DE8484109690T DE3176575D1 (en) 1980-09-02 1981-09-01 Process for the preparation of cephalosporin derivatives using novel thioesters
EP84109690A EP0137227B1 (en) 1980-09-02 1981-09-01 Process for the preparation of cephalosporin derivatives using novel thioesters
DE8181106833T DE3173499D1 (en) 1980-09-02 1981-09-01 Novel thioesters and process for the preparation of the same
EP81106833A EP0047014B1 (en) 1980-09-02 1981-09-01 Novel thioesters and process for the preparation of the same
US06/298,884 US4463179A (en) 1980-09-02 1981-09-02 1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphenylglycine
US06/414,946 US4456754A (en) 1980-09-02 1982-09-03 Process for the preparation of cephalosporin derivatives using thioesters
US06/545,202 US4454323A (en) 1980-09-02 1983-10-25 1-Methyltetrazol-5-ylthio ester of cyanomethylthioacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14685980A JPS5772987A (en) 1980-10-22 1980-10-22 Production of cephalosporanic acid derivative

Publications (1)

Publication Number Publication Date
JPS5772987A true JPS5772987A (en) 1982-05-07

Family

ID=15417169

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14685980A Pending JPS5772987A (en) 1980-09-02 1980-10-22 Production of cephalosporanic acid derivative

Country Status (1)

Country Link
JP (1) JPS5772987A (en)

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