JPS56152487A - Production of cephapirin - Google Patents

Production of cephapirin

Info

Publication number
JPS56152487A
JPS56152487A JP5488380A JP5488380A JPS56152487A JP S56152487 A JPS56152487 A JP S56152487A JP 5488380 A JP5488380 A JP 5488380A JP 5488380 A JP5488380 A JP 5488380A JP S56152487 A JPS56152487 A JP S56152487A
Authority
JP
Japan
Prior art keywords
propylene oxide
cephapirin
pyridylthioacetic
react
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5488380A
Other languages
Japanese (ja)
Inventor
Hiroyasu Sekine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP5488380A priority Critical patent/JPS56152487A/en
Publication of JPS56152487A publication Critical patent/JPS56152487A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: 7-Aminocephalosporanic acid bearing protected carboxyl is made to react with 4-pyridylthioacetic chloride hydrochloride in the presence of propylene oxide to produce high-pyrity cephapirin used as an antibiotic in high yield.
CONSTITUTION: 7-Aminocephalosporanic acid bearing protected carboxyl is dissolved in dichloromethane or the like at room temperature. The solution is combined with propylene oxide and made to react with 4-pyridylthioacetic chloride hydrochloride under stirring to give 7-(4-pyridylthioacetamide)-cephalosporanic ester. The ester group is treated with an acid such as formic acid to give cephapirin.
EFFECT: In this process, the group protecting carboxyls can be readily removed. The use of propylene oxide as an acceptor of hydrogen halide overcomes the defects of purity reduction, yield reduction, the formation of Δ2 cephalosporin derivatives and so on.
COPYRIGHT: (C)1981,JPO&Japio
JP5488380A 1980-04-26 1980-04-26 Production of cephapirin Pending JPS56152487A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5488380A JPS56152487A (en) 1980-04-26 1980-04-26 Production of cephapirin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5488380A JPS56152487A (en) 1980-04-26 1980-04-26 Production of cephapirin

Publications (1)

Publication Number Publication Date
JPS56152487A true JPS56152487A (en) 1981-11-26

Family

ID=12982978

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5488380A Pending JPS56152487A (en) 1980-04-26 1980-04-26 Production of cephapirin

Country Status (1)

Country Link
JP (1) JPS56152487A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793983A (en) * 1980-12-03 1982-06-11 Sankyo Co Ltd Preparation of cephalosporin derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793983A (en) * 1980-12-03 1982-06-11 Sankyo Co Ltd Preparation of cephalosporin derivative
JPH0157117B2 (en) * 1980-12-03 1989-12-04 Sankyo Co

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