JPS56152487A - Production of cephapirin - Google Patents
Production of cephapirinInfo
- Publication number
- JPS56152487A JPS56152487A JP5488380A JP5488380A JPS56152487A JP S56152487 A JPS56152487 A JP S56152487A JP 5488380 A JP5488380 A JP 5488380A JP 5488380 A JP5488380 A JP 5488380A JP S56152487 A JPS56152487 A JP S56152487A
- Authority
- JP
- Japan
- Prior art keywords
- propylene oxide
- cephapirin
- pyridylthioacetic
- react
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
PURPOSE: 7-Aminocephalosporanic acid bearing protected carboxyl is made to react with 4-pyridylthioacetic chloride hydrochloride in the presence of propylene oxide to produce high-pyrity cephapirin used as an antibiotic in high yield.
CONSTITUTION: 7-Aminocephalosporanic acid bearing protected carboxyl is dissolved in dichloromethane or the like at room temperature. The solution is combined with propylene oxide and made to react with 4-pyridylthioacetic chloride hydrochloride under stirring to give 7-(4-pyridylthioacetamide)-cephalosporanic ester. The ester group is treated with an acid such as formic acid to give cephapirin.
EFFECT: In this process, the group protecting carboxyls can be readily removed. The use of propylene oxide as an acceptor of hydrogen halide overcomes the defects of purity reduction, yield reduction, the formation of Δ2 cephalosporin derivatives and so on.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5488380A JPS56152487A (en) | 1980-04-26 | 1980-04-26 | Production of cephapirin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5488380A JPS56152487A (en) | 1980-04-26 | 1980-04-26 | Production of cephapirin |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56152487A true JPS56152487A (en) | 1981-11-26 |
Family
ID=12982978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5488380A Pending JPS56152487A (en) | 1980-04-26 | 1980-04-26 | Production of cephapirin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56152487A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5793983A (en) * | 1980-12-03 | 1982-06-11 | Sankyo Co Ltd | Preparation of cephalosporin derivative |
-
1980
- 1980-04-26 JP JP5488380A patent/JPS56152487A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5793983A (en) * | 1980-12-03 | 1982-06-11 | Sankyo Co Ltd | Preparation of cephalosporin derivative |
JPH0157117B2 (en) * | 1980-12-03 | 1989-12-04 | Sankyo Co |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5334794A (en) | Cephalosporin derivatives and their preparation | |
ES8502702A1 (en) | Process for the isolation and purification of antibiotics. | |
GB1493676A (en) | Antibiotic method and pharmaceutical compositions | |
JPS5495589A (en) | Production of cephalosporin derivative | |
JPS56152487A (en) | Production of cephapirin | |
JPS52125188A (en) | Cephalosporin derivatives and their preparation | |
JPS5323993A (en) | 7-(n-substituted-2-phenylglycineamido)-3-substituted-3-cephem-4-caroxyli acids | |
JPS5283785A (en) | 7-substituted acetamide-3-substituted thiomethyl-3-cephem-4-carboxyric acid, its derivative and salt | |
JPS57116084A (en) | New method of producing cephalosporanic antibiotics | |
JPS52122389A (en) | Cephalosporin derivatives and their preparation | |
JPS5772987A (en) | Production of cephalosporanic acid derivative | |
JPS5759896A (en) | Production of thiazolineazetidinone derivative | |
JPS56135488A (en) | Novel preparative method of cephalosporanic acid derivative | |
JPS53101388A (en) | Novel cephalosporanic acid derivatives and process for their preparation | |
JPS5283777A (en) | Novel 7-methoxycepharosporin | |
JPS57169488A (en) | Cephem compound and its preparation | |
JPS5283865A (en) | Cephalosporin derivatives | |
JPS5523966A (en) | Production of cephalosporin compound | |
JPS53112891A (en) | Production of 7-aminocephalosporanic acid derivative | |
JPS5350193A (en) | Antibacterials | |
JPS5283786A (en) | 7-substituted acetamido-3-alkanoyloxymethyl-3-cephem-4-carboxylic acid , its derivative and salt | |
JPS52108994A (en) | Antibiotics of cephalosporin series | |
JPS5297993A (en) | Novel penicillin and cephalosporin derivatives | |
JPS5384987A (en) | Cephalosporin-analogous antibiotics | |
JPS56135489A (en) | Preparative method of cephalosporanic acid derivative |