JPS5495589A - Production of cephalosporin derivative - Google Patents
Production of cephalosporin derivativeInfo
- Publication number
- JPS5495589A JPS5495589A JP16033977A JP16033977A JPS5495589A JP S5495589 A JPS5495589 A JP S5495589A JP 16033977 A JP16033977 A JP 16033977A JP 16033977 A JP16033977 A JP 16033977A JP S5495589 A JPS5495589 A JP S5495589A
- Authority
- JP
- Japan
- Prior art keywords
- cephatrizine
- propylene glycol
- nontoxic
- anhydrous conditions
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: Cephatrizine, an antibiotic, is dissloved in acidic 1,2-propylene glycol under anhydrous conditions, then neutralized to crystallize out as nontoxic solvate with glycol in pure state and high yield.
CONSTITUTION: 7-[D-α-amino-α-(p-hydroxyphenyl)acetamide]-3-(1,2,3-triazole- 5-ylthiomethyl)-3-cephem-4-carboxylic acid (cephatrizine) or its solvate is dissolved in 1,2-propylene glycol acidified with a nontoxic acid under substantially anhydrous conditions, then neutralized to separate a solvation adduct of cephatrizine and 1,2- propylene glycol as crystals.
EFFECT: The operation under substantially anhydrous conditions helps the easy dissolution of cephatrizine into 1,2-propylene glycol, thus giving high-purity nontoxic crystals in high yield.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16033977A JPS5495589A (en) | 1977-12-30 | 1977-12-30 | Production of cephalosporin derivative |
MX759778U MX5389E (en) | 1977-12-30 | 1978-12-15 | A PROCESS TO PREPARE A SOLVATED COMPOUND OF 1,2-PROPYLENE GLYCOL ACID 7- (D-ALPHA-AMINO ALPHA- (P-HYDROXYPHENYL) ACETAMIDE) -3- (1,2,3-TRIAZOL-5-ILTIOMETIL) -3 -CEFEM-4-CARBOXILICO |
ES476196A ES476196A1 (en) | 1977-12-30 | 1978-12-20 | Production of cephalosporin derivative |
CA318,788A CA1101840A (en) | 1977-12-30 | 1978-12-28 | Process for preparing cephalosporin compounds |
IT52465/78A IT1109398B (en) | 1977-12-30 | 1978-12-28 | PROCEDURE FOR PREPARING CEPHALOSPORIN COMPOUNDS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16033977A JPS5495589A (en) | 1977-12-30 | 1977-12-30 | Production of cephalosporin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5495589A true JPS5495589A (en) | 1979-07-28 |
Family
ID=15712832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16033977A Pending JPS5495589A (en) | 1977-12-30 | 1977-12-30 | Production of cephalosporin derivative |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS5495589A (en) |
CA (1) | CA1101840A (en) |
ES (1) | ES476196A1 (en) |
IT (1) | IT1109398B (en) |
MX (1) | MX5389E (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997012889A1 (en) * | 1995-09-29 | 1997-04-10 | Gist-Brocades B.V. | Penicillin glycolate |
WO2004060347A3 (en) * | 2002-09-03 | 2004-11-04 | Transform Pharmaceuticals Inc | Pharmaceutical propylene glycol solvate compositions |
AU2003243699B2 (en) * | 2002-06-21 | 2009-01-15 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
US10633344B2 (en) | 2002-03-01 | 2020-04-28 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2339328A3 (en) * | 2002-12-30 | 2011-07-13 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of celecoxib |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
CA2570949A1 (en) | 2006-12-12 | 2008-06-12 | Apotex Pharmachem Inc. | Ibandronate sodium propylene glycol solvate and processes for the preparation thereof |
US7834195B2 (en) | 2007-01-24 | 2010-11-16 | Apotex Pharmachem Inc. | Atorvastatin calcium propylene glycol solvates |
AR065809A1 (en) | 2007-03-22 | 2009-07-01 | Bristol Myers Squibb Co | PHARMACEUTICAL FORMULATIONS CONTAINING AN SGLT2 INHIBITOR |
CN103641845B (en) * | 2013-12-11 | 2015-08-19 | 中国医药集团总公司四川抗菌素工业研究所 | A kind of preparation method of cefatrizine propylene glycol |
-
1977
- 1977-12-30 JP JP16033977A patent/JPS5495589A/en active Pending
-
1978
- 1978-12-15 MX MX759778U patent/MX5389E/en unknown
- 1978-12-20 ES ES476196A patent/ES476196A1/en not_active Expired
- 1978-12-28 IT IT52465/78A patent/IT1109398B/en active
- 1978-12-28 CA CA318,788A patent/CA1101840A/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997012889A1 (en) * | 1995-09-29 | 1997-04-10 | Gist-Brocades B.V. | Penicillin glycolate |
US10633344B2 (en) | 2002-03-01 | 2020-04-28 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
AU2003243699B2 (en) * | 2002-06-21 | 2009-01-15 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
AU2009201465B2 (en) * | 2002-06-21 | 2011-06-30 | Transform Pharmaceuticals, Inc. | Pharmaceutical Compositions with Improved Dissolution |
WO2004060347A3 (en) * | 2002-09-03 | 2004-11-04 | Transform Pharmaceuticals Inc | Pharmaceutical propylene glycol solvate compositions |
Also Published As
Publication number | Publication date |
---|---|
ES476196A1 (en) | 1979-11-16 |
IT1109398B (en) | 1985-12-16 |
CA1101840A (en) | 1981-05-26 |
IT7852465A0 (en) | 1978-12-28 |
MX5389E (en) | 1983-07-07 |
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