JPS5495589A - Production of cephalosporin derivative - Google Patents

Production of cephalosporin derivative

Info

Publication number
JPS5495589A
JPS5495589A JP16033977A JP16033977A JPS5495589A JP S5495589 A JPS5495589 A JP S5495589A JP 16033977 A JP16033977 A JP 16033977A JP 16033977 A JP16033977 A JP 16033977A JP S5495589 A JPS5495589 A JP S5495589A
Authority
JP
Japan
Prior art keywords
cephatrizine
propylene glycol
nontoxic
anhydrous conditions
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16033977A
Other languages
Japanese (ja)
Inventor
Masataka Fukumura
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP16033977A priority Critical patent/JPS5495589A/en
Priority to MX759778U priority patent/MX5389E/en
Priority to ES476196A priority patent/ES476196A1/en
Priority to CA318,788A priority patent/CA1101840A/en
Priority to IT52465/78A priority patent/IT1109398B/en
Publication of JPS5495589A publication Critical patent/JPS5495589A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: Cephatrizine, an antibiotic, is dissloved in acidic 1,2-propylene glycol under anhydrous conditions, then neutralized to crystallize out as nontoxic solvate with glycol in pure state and high yield.
CONSTITUTION: 7-[D-α-amino-α-(p-hydroxyphenyl)acetamide]-3-(1,2,3-triazole- 5-ylthiomethyl)-3-cephem-4-carboxylic acid (cephatrizine) or its solvate is dissolved in 1,2-propylene glycol acidified with a nontoxic acid under substantially anhydrous conditions, then neutralized to separate a solvation adduct of cephatrizine and 1,2- propylene glycol as crystals.
EFFECT: The operation under substantially anhydrous conditions helps the easy dissolution of cephatrizine into 1,2-propylene glycol, thus giving high-purity nontoxic crystals in high yield.
COPYRIGHT: (C)1979,JPO&Japio
JP16033977A 1977-12-30 1977-12-30 Production of cephalosporin derivative Pending JPS5495589A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP16033977A JPS5495589A (en) 1977-12-30 1977-12-30 Production of cephalosporin derivative
MX759778U MX5389E (en) 1977-12-30 1978-12-15 A PROCESS TO PREPARE A SOLVATED COMPOUND OF 1,2-PROPYLENE GLYCOL ACID 7- (D-ALPHA-AMINO ALPHA- (P-HYDROXYPHENYL) ACETAMIDE) -3- (1,2,3-TRIAZOL-5-ILTIOMETIL) -3 -CEFEM-4-CARBOXILICO
ES476196A ES476196A1 (en) 1977-12-30 1978-12-20 Production of cephalosporin derivative
CA318,788A CA1101840A (en) 1977-12-30 1978-12-28 Process for preparing cephalosporin compounds
IT52465/78A IT1109398B (en) 1977-12-30 1978-12-28 PROCEDURE FOR PREPARING CEPHALOSPORIN COMPOUNDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16033977A JPS5495589A (en) 1977-12-30 1977-12-30 Production of cephalosporin derivative

Publications (1)

Publication Number Publication Date
JPS5495589A true JPS5495589A (en) 1979-07-28

Family

ID=15712832

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16033977A Pending JPS5495589A (en) 1977-12-30 1977-12-30 Production of cephalosporin derivative

Country Status (5)

Country Link
JP (1) JPS5495589A (en)
CA (1) CA1101840A (en)
ES (1) ES476196A1 (en)
IT (1) IT1109398B (en)
MX (1) MX5389E (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012889A1 (en) * 1995-09-29 1997-04-10 Gist-Brocades B.V. Penicillin glycolate
WO2004060347A3 (en) * 2002-09-03 2004-11-04 Transform Pharmaceuticals Inc Pharmaceutical propylene glycol solvate compositions
AU2003243699B2 (en) * 2002-06-21 2009-01-15 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US10633344B2 (en) 2002-03-01 2020-04-28 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2339328A3 (en) * 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of celecoxib
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
CA2570949A1 (en) 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
US7834195B2 (en) 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
AR065809A1 (en) 2007-03-22 2009-07-01 Bristol Myers Squibb Co PHARMACEUTICAL FORMULATIONS CONTAINING AN SGLT2 INHIBITOR
CN103641845B (en) * 2013-12-11 2015-08-19 中国医药集团总公司四川抗菌素工业研究所 A kind of preparation method of cefatrizine propylene glycol

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012889A1 (en) * 1995-09-29 1997-04-10 Gist-Brocades B.V. Penicillin glycolate
US10633344B2 (en) 2002-03-01 2020-04-28 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
AU2003243699B2 (en) * 2002-06-21 2009-01-15 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
AU2009201465B2 (en) * 2002-06-21 2011-06-30 Transform Pharmaceuticals, Inc. Pharmaceutical Compositions with Improved Dissolution
WO2004060347A3 (en) * 2002-09-03 2004-11-04 Transform Pharmaceuticals Inc Pharmaceutical propylene glycol solvate compositions

Also Published As

Publication number Publication date
ES476196A1 (en) 1979-11-16
IT1109398B (en) 1985-12-16
CA1101840A (en) 1981-05-26
IT7852465A0 (en) 1978-12-28
MX5389E (en) 1983-07-07

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