JPS56150094A - Preparation of cephamycin antibiotic - Google Patents

Preparation of cephamycin antibiotic

Info

Publication number
JPS56150094A
JPS56150094A JP5305880A JP5305880A JPS56150094A JP S56150094 A JPS56150094 A JP S56150094A JP 5305880 A JP5305880 A JP 5305880A JP 5305880 A JP5305880 A JP 5305880A JP S56150094 A JPS56150094 A JP S56150094A
Authority
JP
Japan
Prior art keywords
formula
compound
group
cephem
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5305880A
Other languages
Japanese (ja)
Other versions
JPH0128037B2 (en
Inventor
Tetsuo Hiraoka
Masao Sugimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP5305880A priority Critical patent/JPS56150094A/en
Publication of JPS56150094A publication Critical patent/JPS56150094A/en
Publication of JPH0128037B2 publication Critical patent/JPH0128037B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To obtain an antimicrobial agent Cefmetazole, etc. readily without using an unstable raw material, by cyanomethylating a novel cephem compound.
CONSTITUTION: A 7β-mercaptoacetamido-7α-methoxy-3-cephem compound of formula I (R1 is a group which will not participate in the reaction; R2 is carboxyl or protected carboxyl) is reacted with a novel compound of the formula NCCH2X (X is halogen, etc.) in the presence of a base, and the protecting group is removed when R2 is an esterified carboxyl group to give a 7β-cyanomethylthioacetamido- 7α-methoxy-3-substituted-3-cephem-4-carboxylic acid of formula II. An unstable raw material such as cyanomethylthioacetyl halide need not be used. The novel compound of formula I is obtained by removing the protecting group R3 from a compound of formula III (R3 is a protecting group of the mercapto group) by the conventional method.
COPYRIGHT: (C)1981,JPO&Japio
JP5305880A 1980-04-22 1980-04-22 Preparation of cephamycin antibiotic Granted JPS56150094A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5305880A JPS56150094A (en) 1980-04-22 1980-04-22 Preparation of cephamycin antibiotic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5305880A JPS56150094A (en) 1980-04-22 1980-04-22 Preparation of cephamycin antibiotic

Publications (2)

Publication Number Publication Date
JPS56150094A true JPS56150094A (en) 1981-11-20
JPH0128037B2 JPH0128037B2 (en) 1989-05-31

Family

ID=12932242

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5305880A Granted JPS56150094A (en) 1980-04-22 1980-04-22 Preparation of cephamycin antibiotic

Country Status (1)

Country Link
JP (1) JPS56150094A (en)

Also Published As

Publication number Publication date
JPH0128037B2 (en) 1989-05-31

Similar Documents

Publication Publication Date Title
JPS5334794A (en) Cephalosporin derivatives and their preparation
JPS51149296A (en) Cephems or penams and their preparation
JPS56125392A (en) Cepham and cephem compound and preparation thereof
JPS57118555A (en) Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component
JPS56150094A (en) Preparation of cephamycin antibiotic
JPS5212141A (en) Novel amino benzoic acid derivatives, their preparation, and pharmaceu tical compositions therefrom
JPS6492A (en) Novel glycerin derivative, production thereof, hypotensor containing said derivative
JPS5225740A (en) Preparation of o-acyl-amidinophenols or acid addition salts thereof
JPS57188595A (en) 7alpha-methoxycephem compound and its preparation
JPS5283863A (en) Cephem or penam compounds
JPS5353638A (en) Alpha-acetyl cinnamic acid ester derivatives, their preparation and theirherbicides containing the same
JPS57144254A (en) 2-substituted-2-oxoazetidine derivative and its preparation
JPS5365882A (en) 1,4-dihydro-4-oxonicotinic acids and process for preparation of the same
JPS527919A (en) Process for preparation of beta-sulfenylacrylic acid and its salt
JPS57118560A (en) Preparation of 1-sulfo-2-oxoazetidine and its intermediate
JPS51145558A (en) Stabilizer composition for halogen containing resins
JPS5283866A (en) Cephem or penam compounds
JPS51146427A (en) Process for preparation of phenyl halobutyrate
JPS53103415A (en) Preparation of trihalocarboxylic acid ester
JPS55100372A (en) 5-fluorouracil derivative and its preparation
JPS51122048A (en) Process for preparation of tetralone- (1)-dicarboxylic acid-(3,7) and its monoalkyl esters
JPS57140751A (en) Novel peptide, its preparation and use
JPS56135489A (en) Preparative method of cephalosporanic acid derivative
EP0081320A3 (en) Preparation of acetic acid derivatives
JPS5279081A (en) Preparation of novel 7-methoxycephalosporins