JPS577484A - Preparation of cephalosporin derivative - Google Patents

Preparation of cephalosporin derivative

Info

Publication number
JPS577484A
JPS577484A JP8090580A JP8090580A JPS577484A JP S577484 A JPS577484 A JP S577484A JP 8090580 A JP8090580 A JP 8090580A JP 8090580 A JP8090580 A JP 8090580A JP S577484 A JPS577484 A JP S577484A
Authority
JP
Japan
Prior art keywords
compound
formula
solvent
hydrolyzed
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8090580A
Other languages
Japanese (ja)
Inventor
Yoshimasa Machida
Isao Saito
Seiichiro Nomoto
Shigeto Nemoto
Takumi Sugiyama
Hironori Ikuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP8090580A priority Critical patent/JPS577484A/en
Publication of JPS577484A publication Critical patent/JPS577484A/en
Pending legal-status Critical Current

Links

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 is acetoxy or heterocyclic ring thio containing nitrogen ; n is 2 or 3).
EXAMPLE: 7β-[ D-2-( 6,7-Dihydroxychromone-3-carboxyamido )-2-( 4-hydroxyphenyl)acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid.
USE: An antimicrobial agent.
PROCESS: A compound of formula II is reacted with a compound of formula III in the presence of an acidic catalyst, e.g. p-toluenesulfonic acid, in an inert solvent, e.g. dichloromethane, to give a compound of formula IV. The resultant compound of formula IV is then hydrolyzed in a hydrophilic solvent, e.g. methanol, and/or a mixed solvent of water with the hydrophilic solvent in the presence of a base, e.g. NaHCO3, to afford a compound of formula V, which is then hydrolyzed in the presence of an acid, e.g. p-toluenesulfonic acid, in the same solvent as described above to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8090580A 1980-06-17 1980-06-17 Preparation of cephalosporin derivative Pending JPS577484A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8090580A JPS577484A (en) 1980-06-17 1980-06-17 Preparation of cephalosporin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8090580A JPS577484A (en) 1980-06-17 1980-06-17 Preparation of cephalosporin derivative

Publications (1)

Publication Number Publication Date
JPS577484A true JPS577484A (en) 1982-01-14

Family

ID=13731382

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8090580A Pending JPS577484A (en) 1980-06-17 1980-06-17 Preparation of cephalosporin derivative

Country Status (1)

Country Link
JP (1) JPS577484A (en)

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