JPS5645473A - Preparation of 6-fluoro-1,8-naphthyridine derivative - Google Patents

Preparation of 6-fluoro-1,8-naphthyridine derivative

Info

Publication number
JPS5645473A
JPS5645473A JP12222079A JP12222079A JPS5645473A JP S5645473 A JPS5645473 A JP S5645473A JP 12222079 A JP12222079 A JP 12222079A JP 12222079 A JP12222079 A JP 12222079A JP S5645473 A JPS5645473 A JP S5645473A
Authority
JP
Japan
Prior art keywords
compound
formula
fluoro
alkyl
infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12222079A
Other languages
Japanese (ja)
Inventor
Junichi Matsumoto
Yoshiyuki Takase
Akiyuki Miyamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP12222079A priority Critical patent/JPS5645473A/en
Priority to FI802965A priority patent/FI67381C/en
Priority to ES495190A priority patent/ES8106902A1/en
Priority to HU802307A priority patent/HU184827B/en
Publication of JPS5645473A publication Critical patent/JPS5645473A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound of formula I (R1 is H or protecting group; R2 is alkenyl, alkyl, etc.), and a salt thereof.
EXAMPLE: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-( 1-piperazinyl )-1,8-naphthyridine- 3-carboxylic acid.
USE: An antimicrobial agent and a synthetic intermediate therefor having improved effects on urinary tract infection, ascending renal infection and systemic infection even in a small dose with very low toxicity.
PROCESS: A compound of formula II (R3 is H or alkyl) is oxidized with a hypohalogenate or silver oxide, or reacted with an iodine-pyridine mixture and then treated with an alkali to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP12222079A 1979-09-21 1979-09-21 Preparation of 6-fluoro-1,8-naphthyridine derivative Pending JPS5645473A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP12222079A JPS5645473A (en) 1979-09-21 1979-09-21 Preparation of 6-fluoro-1,8-naphthyridine derivative
FI802965A FI67381C (en) 1979-09-21 1980-09-19 FRUIT PROCEDURE FOR FRAMSTAELLNING AV ETT 6-FLUORO-1,8-NAPHTHYRIDINDERIVAT ANVAENDBART SOM ANTIBAKTERIELLT MEDEL
ES495190A ES8106902A1 (en) 1979-09-21 1980-09-19 Preparation of 66fluoroo1*88naphthyridine derivative
HU802307A HU184827B (en) 1979-09-21 1980-09-19 Process for preparing 6-fluoro-1,8-na phthy ridyl-derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12222079A JPS5645473A (en) 1979-09-21 1979-09-21 Preparation of 6-fluoro-1,8-naphthyridine derivative

Publications (1)

Publication Number Publication Date
JPS5645473A true JPS5645473A (en) 1981-04-25

Family

ID=14830515

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12222079A Pending JPS5645473A (en) 1979-09-21 1979-09-21 Preparation of 6-fluoro-1,8-naphthyridine derivative

Country Status (4)

Country Link
JP (1) JPS5645473A (en)
ES (1) ES8106902A1 (en)
FI (1) FI67381C (en)
HU (1) HU184827B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025545A1 (en) * 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025545A1 (en) * 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same

Also Published As

Publication number Publication date
FI802965A (en) 1981-03-22
ES495190A0 (en) 1981-09-01
FI67381C (en) 1985-03-11
ES8106902A1 (en) 1981-09-01
HU184827B (en) 1984-10-29
FI67381B (en) 1984-11-30

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