JPS5583785A - 6-fluoro-1,8-naphthyridine derivative and its salt - Google Patents

6-fluoro-1,8-naphthyridine derivative and its salt

Info

Publication number
JPS5583785A
JPS5583785A JP15793978A JP15793978A JPS5583785A JP S5583785 A JPS5583785 A JP S5583785A JP 15793978 A JP15793978 A JP 15793978A JP 15793978 A JP15793978 A JP 15793978A JP S5583785 A JPS5583785 A JP S5583785A
Authority
JP
Japan
Prior art keywords
salt
fluoro
compound
formula
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15793978A
Other languages
Japanese (ja)
Inventor
Junichi Matsumoto
Yoshiyuki Takase
Yoshio Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP15793978A priority Critical patent/JPS5583785A/en
Priority to AR277659A priority patent/AR223983A1/en
Priority to AU50049/79A priority patent/AU530052B2/en
Priority to YU2032/79A priority patent/YU42193B/en
Priority to DD79215122A priority patent/DD145753A5/en
Priority to MX10123879U priority patent/MX6111E/en
Priority to US06/068,966 priority patent/US4359578A/en
Priority to HU79BE1361A priority patent/HU179927B/en
Priority to DK355679A priority patent/DK153552C/en
Priority to DE7979400587T priority patent/DE2961979D1/en
Priority to NO792760A priority patent/NO153136C/en
Priority to CA000334439A priority patent/CA1168241A/en
Priority to FI792645A priority patent/FI66379C/en
Priority to CS795770A priority patent/CS235502B2/en
Priority to ES483629A priority patent/ES483629A1/en
Priority to EP79400587A priority patent/EP0009425B1/en
Priority to PL1979226094A priority patent/PL120154B1/en
Priority to PL1979217926A priority patent/PL120114B1/en
Priority to PH22967A priority patent/PH14287A/en
Priority to RO79103694A priority patent/RO81942A/en
Priority to RO79103693A priority patent/RO81939A/en
Priority to RO7998656A priority patent/RO77558A/en
Priority to RO79103692A priority patent/RO81940A/en
Priority to ES491222A priority patent/ES8202023A1/en
Publication of JPS5583785A publication Critical patent/JPS5583785A/en
Priority to SU802969197A priority patent/SU1029829A3/en
Priority to AR283027A priority patent/AR227529A1/en
Priority to AR283026A priority patent/AR225195A1/en
Priority to US06/264,824 priority patent/US4352803A/en
Priority to IN1487/CAL/82A priority patent/IN154878B/en
Priority to CS835364A priority patent/CS235545B2/en
Priority to CS835365A priority patent/CS235546B2/en
Priority to YU319/85A priority patent/YU42615B/en
Priority to YU318/85A priority patent/YU42614B/en
Priority to YU317/85A priority patent/YU42637B/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:1-Ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-( 1-piperazinyl )-1, 8-naphthyridine-3-carboxylic acid and its salt.
USE: Medicines having an antibacterial action on Gram-negative bacteria, including Pseudomonas aeruginosa, drugs for animals and fishes, and food preservatives.
PROCESS: A compound of formula II: (R1 is H or protecting group; R2 is H or lower alkyl group) is ethylated with an agent, e.g. ethyl iodide, in an inert solvent, e.g. ethanol, and subjected to hydrogenolysis if necessary, to give the compound of formula I and its salt. An acid acceptor, e.g. an alkali carbonate, may further accelerate the reaction.
COPYRIGHT: (C)1980,JPO&Japio
JP15793978A 1978-08-25 1978-12-20 6-fluoro-1,8-naphthyridine derivative and its salt Pending JPS5583785A (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
JP15793978A JPS5583785A (en) 1978-12-20 1978-12-20 6-fluoro-1,8-naphthyridine derivative and its salt
AR277659A AR223983A1 (en) 1978-08-25 1979-08-09 A PROCEDURE FOR PREPARING 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-3-CARBOXYLIC ACID DERIVATIVES
AU50049/79A AU530052B2 (en) 1978-08-25 1979-08-17 Naphthyridine derivatives
YU2032/79A YU42193B (en) 1978-08-25 1979-08-20 Process for preparing 1,8-naphthydrine compound
DD79215122A DD145753A5 (en) 1978-08-25 1979-08-22 PROCESS FOR THE PREPARATION OF NAPHTHYRIDINE DERIVATIVES
MX10123879U MX6111E (en) 1978-08-25 1979-08-23 PROCEDURE FOR THE PREPARATION OF 1,8 NAFTIRIDINE DERIVATIVES
US06/068,966 US4359578A (en) 1978-08-25 1979-08-23 Naphthyridine derivatives and salts thereof useful as antibacterial agents
HU79BE1361A HU179927B (en) 1978-08-25 1979-08-23 Process for preparing naphthyridine derivatives
PL1979217926A PL120114B1 (en) 1978-08-25 1979-08-24 Process for preparing novel derivatives of 1,8-naphtiridine
DE7979400587T DE2961979D1 (en) 1978-08-25 1979-08-24 Novel naphtyridine derivatives and pharmaceutical compositions containing them
NO792760A NO153136C (en) 1978-08-25 1979-08-24 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE NAFTYRIDINE DERIVATIVES.
CA000334439A CA1168241A (en) 1978-08-25 1979-08-24 Naphthyridine derivatives, intermediates thereof and processes for preparation thereof
FI792645A FI66379C (en) 1978-08-25 1979-08-24 ANALOGIFICATION OF THERAPEUTIC ANALYSIS OF 6-HALOGEN-1,4-DIHYDRO-4-OXO-7- (1-PIPERAZINYL) -1-SUBSTITUTES 1,8-NAPHTHYRIDINE-3-CARBOXYL SYROR
CS795770A CS235502B2 (en) 1978-08-25 1979-08-24 Method of 1-ethyl or vinyl-6-halogen-1-4-dihydro-4-oxo-7- (1-piperazinyl)-1,8-naphtyridin-3-carboxyl acid production
ES483629A ES483629A1 (en) 1978-08-25 1979-08-24 Novel naphtyridine derivatives and pharmaceutical compositions containing them.
EP79400587A EP0009425B1 (en) 1978-08-25 1979-08-24 Novel naphtyridine derivatives and pharmaceutical compositions containing them
PL1979226094A PL120154B1 (en) 1978-12-20 1979-08-24 Process for preparing ovel derivatives of 1,8-naphtiridine
DK355679A DK153552C (en) 1978-08-25 1979-08-24 ANALOGY PROCEDURE FOR PREPARING 1,8-NAPHTHYRIDE INGREDIATES
PH22967A PH14287A (en) 1978-08-25 1979-08-27 Naphthyridine derivatives,pharmaceutical compositions containing same and method of treatment thereof
RO79103693A RO81939A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF 6-HALO-4-OXO-7- (1-PYPERAZINYL) -1,8-NAPHTHYRIDINE DERIVATIVES
RO79103692A RO81940A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF 6-HALO-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDINE
RO79103694A RO81942A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF NAPHTIRIDINE DERIVATIVES
RO7998656A RO77558A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF NAPHTIRIDINE DERIVATIVES
ES491222A ES8202023A1 (en) 1978-12-20 1980-05-02 66fluoroo1*88naphthyridine derivative and its salt
SU802969197A SU1029829A3 (en) 1978-12-20 1980-09-02 Process for preparing derivatives of 1,8-naphthiridine or their pharmaceutically acceptable salts
AR283027A AR227529A1 (en) 1978-08-25 1980-10-28 A PROCEDURE FOR PREPARING A 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-CARBOXYLIC ACID DERIVATIVE
AR283026A AR225195A1 (en) 1978-08-25 1980-10-28 A PROCEDURE FOR PREPARING A DERIVATIVE OF 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAPHTIRIDINE AND INTERMEDIARIES USED THEREOF
US06/264,824 US4352803A (en) 1978-08-25 1981-05-18 Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof
IN1487/CAL/82A IN154878B (en) 1978-08-25 1982-12-17
CS835365A CS235546B2 (en) 1978-08-25 1983-07-15 Method of 1-ethyl-6-halogen-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine derivatives preparation
CS835364A CS235545B2 (en) 1978-08-25 1983-07-15 Method of 1-ethyl or vinyl-6-halogen-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine derivatives preparation
YU319/85A YU42615B (en) 1978-08-25 1985-02-28 Process for preparing 1,8-naphthydrine compound
YU318/85A YU42614B (en) 1978-08-25 1985-02-28 Process for preparing 1,8-naphthydrine compound
YU317/85A YU42637B (en) 1978-08-25 1985-02-28 Process for preparing 1,8-naphthydrine compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15793978A JPS5583785A (en) 1978-12-20 1978-12-20 6-fluoro-1,8-naphthyridine derivative and its salt

Publications (1)

Publication Number Publication Date
JPS5583785A true JPS5583785A (en) 1980-06-24

Family

ID=15660768

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15793978A Pending JPS5583785A (en) 1978-08-25 1978-12-20 6-fluoro-1,8-naphthyridine derivative and its salt

Country Status (4)

Country Link
JP (1) JPS5583785A (en)
ES (1) ES8202023A1 (en)
PL (1) PL120154B1 (en)
SU (1) SU1029829A3 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5772981A (en) * 1980-10-22 1982-05-07 Dainippon Pharmaceut Co Ltd 1,8-naphthyridine derivative and its salt
JPS6032790A (en) * 1983-08-01 1985-02-19 Dainippon Pharmaceut Co Ltd 1,8-naphthyridines
JPS61152849A (en) * 1984-12-26 1986-07-11 帝人株式会社 Pile cloth for interior

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5772981A (en) * 1980-10-22 1982-05-07 Dainippon Pharmaceut Co Ltd 1,8-naphthyridine derivative and its salt
JPS6032790A (en) * 1983-08-01 1985-02-19 Dainippon Pharmaceut Co Ltd 1,8-naphthyridines
JPH0373549B2 (en) * 1983-08-01 1991-11-22 Dainippon Pharmaceutical Co
JPS61152849A (en) * 1984-12-26 1986-07-11 帝人株式会社 Pile cloth for interior

Also Published As

Publication number Publication date
ES491222A0 (en) 1982-01-01
PL120154B1 (en) 1982-02-27
SU1029829A3 (en) 1983-07-15
ES8202023A1 (en) 1982-01-01

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