BG50163A3 - Method for preparing of acyl derivatives - Google Patents

Method for preparing of acyl derivatives

Info

Publication number
BG50163A3
BG50163A3 BG043718A BG4371879A BG50163A3 BG 50163 A3 BG50163 A3 BG 50163A3 BG 043718 A BG043718 A BG 043718A BG 4371879 A BG4371879 A BG 4371879A BG 50163 A3 BG50163 A3 BG 50163A3
Authority
BG
Bulgaria
Prior art keywords
group
asym
triazin
methyl
preparing
Prior art date
Application number
BG043718A
Other languages
Bulgarian (bg)
Inventor
Marc Montavon
Roland Reiner
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH588278A external-priority patent/CH641468A5/en
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of BG50163A3 publication Critical patent/BG50163A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Reinforcement Elements For Buildings (AREA)
  • Mutual Connection Of Rods And Tubes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Съединенията намират приложение в медицината. Те проявяват антимикробна активност. Имат обща формула в която х означава 1, 2, 5, 6-тетрахидро-2-метил-5,6-диоксо-асим.-триазин-3-илова група, 2,5-дихидро-6-хидрокси-2-метил-5-оксо-асим.-триазин-3-илова група или 1,4,5,6-тетрахидро-4-метил-5,6-диоксо-асим.-триазин-3-илова група. Методът сесъстои в това, че от карбонова киселина с формуласе отцепва защитната група r. 9 претенцииThe compounds are used in medicine. They exhibit antimicrobial activity. They have a general formula in which x stands for 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-asym.-triazin-3-yl group, 2,5-dihydro-6-hydroxy-2-methyl -5-oxo-asym.-triazin-3-yl group or 1,4,5,6-tetrahydro-4-methyl-5,6-dioxo-asym.-triazin-3-yl group. The method consists in cleaving the protecting group r from a carboxylic acid of the formula. 9 claims

BG043718A 1978-05-30 1979-05-25 Method for preparing of acyl derivatives BG50163A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH588278A CH641468A5 (en) 1978-05-30 1978-05-30 CEPHEM DERIVATIVES.
CH224879 1979-03-08

Publications (1)

Publication Number Publication Date
BG50163A3 true BG50163A3 (en) 1992-05-15

Family

ID=25689901

Family Applications (1)

Application Number Title Priority Date Filing Date
BG043718A BG50163A3 (en) 1978-05-30 1979-05-25 Method for preparing of acyl derivatives

Country Status (40)

Country Link
EP (2) EP0005830B1 (en)
JP (2) JPS54157596A (en)
AT (3) AT367764B (en)
BG (1) BG50163A3 (en)
BR (1) BR7903368A (en)
CA (1) CA1141373A (en)
CS (1) CS219254B2 (en)
CU (1) CU35088A (en)
CY (1) CY1182A (en)
DD (1) DD143911A5 (en)
DE (4) DE2963720D1 (en)
DK (1) DK149282C (en)
EG (1) EG14153A (en)
ES (2) ES480990A1 (en)
FI (1) FI65434C (en)
FR (2) FR2427337A1 (en)
GB (2) GB2099418B (en)
GR (1) GR72242B (en)
HK (1) HK31383A (en)
HU (1) HU183089B (en)
IE (1) IE49047B1 (en)
IL (1) IL57392A (en)
IS (1) IS1203B6 (en)
IT (1) IT1121517B (en)
KE (1) KE3268A (en)
LU (1) LU81325A1 (en)
MC (1) MC1259A1 (en)
MT (1) MTP845B (en)
MY (1) MY8400127A (en)
NL (1) NL7904083A (en)
NO (1) NO159797C (en)
NZ (1) NZ190532A (en)
OA (1) OA06263A (en)
PH (1) PH15148A (en)
PL (1) PL122458B1 (en)
PT (1) PT69698A (en)
RO (1) RO77560A (en)
SE (1) SE437522B (en)
SG (1) SG10483G (en)
YU (3) YU42485B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI67385C (en) * 1979-11-21 1985-03-11 Hoffmann La Roche PROCEDURE FOR FRAMSTATION OF AV (6R 7R) -7- (2- (2-AMINO-4-THIAZOLYL) -2- (Z-METHOXYIMINO) ACETAMIDO) -3-CEFEM-4-CARBOXYL SYRATER DERIVATIVES
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
CA1154009A (en) * 1980-03-25 1983-09-20 Roland Reiner Cephalosporin derivatives
NZ196552A (en) * 1980-03-25 1984-07-06 Hoffmann La Roche Cephalosporin derivatives and pharmaceutical compositions;intermediate cephalosporins
GR75706B (en) * 1980-06-30 1984-08-02 Sanofi Sa
US4308267A (en) 1980-07-03 1981-12-29 Smithkline Corporation 7-[2-Alkoxyimino-2-(amino-thiazole)acetamido]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins
DK379581A (en) * 1980-10-06 1982-04-07 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF ACYL DERIVATIVES
FR2494278A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0058250A3 (en) * 1981-02-17 1983-08-17 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporin derivatives, their preparation and pharmaceutical compositions containing them
EP0185220A3 (en) * 1984-12-19 1987-09-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Intermediates for the preparation of cephalosporins
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
RU2021274C1 (en) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Process for preparing aminothiazolyl cephalosporin derivatives
KR950014571B1 (en) * 1991-11-18 1995-12-08 제일제당주식회사 Process for the preparation of cephem derivatives
AT398764B (en) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih METHOD FOR PRODUCING CEFTRIAXONDINATRIUM SALZHEMIHEPTAHYDRATE
AT399877B (en) * 1992-02-20 1995-08-25 Biochemie Gmbh NEW METHOD FOR PRODUCING CEFTRIAXONE
KR100197788B1 (en) * 1995-06-30 1999-06-15 김충환 Processes for manufacturing cephem derivatives
DE102011117421A1 (en) 2011-11-02 2013-05-02 Hans-Peter Gabel Pharmaceutical composition useful for treating Lyme disease, comprises mixture of active substances including ceftriaxone and cefotaxime
RU2504548C1 (en) * 2012-09-28 2014-01-20 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) DERIVATIVE OF β-LACTAM CEFTRIAXONE ANTIBIOTIC

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH609989A5 (en) * 1974-06-21 1979-03-30 Hoffmann La Roche Process for the preparation of acyl derivatives
CA1100129A (en) * 1974-08-02 1981-04-28 William H.W. Lunn Cephalosporin compounds
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
DK162391C (en) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
GR63088B (en) 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
JPS5329936A (en) * 1976-08-31 1978-03-20 Takeda Chem Ind Ltd Antibiotic composition
NL7805715A (en) * 1977-06-03 1978-12-05 Hoffmann La Roche METHOD FOR PREPARING ACYL DERIVATIVES.
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins

Also Published As

Publication number Publication date
MTP845B (en) 1980-07-21
CA1141373A (en) 1983-02-15
YU123379A (en) 1983-04-30
EP0045525B1 (en) 1984-04-25
EG14153A (en) 1983-03-31
SG10483G (en) 1983-12-16
BR7903368A (en) 1979-12-11
GB2022090B (en) 1982-12-15
YU74485A (en) 1987-12-31
JPS613795B2 (en) 1986-02-04
RO77560A (en) 1982-04-12
IS2490A7 (en) 1979-12-01
ATE1586T1 (en) 1982-10-15
EP0005830A1 (en) 1979-12-12
OA06263A (en) 1981-06-30
DE2954159C2 (en) 1983-10-06
PL122458B1 (en) 1982-07-31
IT7923049A0 (en) 1979-05-28
NZ190532A (en) 1983-03-15
NO159797B (en) 1988-10-31
GB2099418B (en) 1983-06-02
JPS613355B2 (en) 1986-01-31
ES480990A1 (en) 1980-08-16
JPS54157596A (en) 1979-12-12
MC1259A1 (en) 1980-01-14
FI791703A (en) 1979-12-01
AU4736679A (en) 1979-12-06
ES8101606A1 (en) 1980-12-16
DE2922036A1 (en) 1979-12-06
LU81325A1 (en) 1980-12-16
YU74585A (en) 1987-12-31
DE2922036C2 (en) 1983-02-17
EP0045525A2 (en) 1982-02-10
PL215972A1 (en) 1980-02-11
DE2963720D1 (en) 1982-11-04
IL57392A (en) 1982-05-31
FI65434C (en) 1984-05-10
EP0005830B1 (en) 1982-09-22
NO159797C (en) 1989-02-08
CY1182A (en) 1983-10-07
AT367764B (en) 1982-07-26
IE49047B1 (en) 1985-07-24
IT1121517B (en) 1986-04-02
KE3268A (en) 1983-05-13
ATA390479A (en) 1981-12-15
AU524230B2 (en) 1982-09-09
DK149282C (en) 1986-09-01
YU45257B (en) 1992-05-28
ES488687A0 (en) 1980-12-16
FI65434B (en) 1984-01-31
HU183089B (en) 1984-04-28
GR72242B (en) 1983-10-04
PH15148A (en) 1982-08-24
DK222679A (en) 1979-12-01
FR2509312A1 (en) 1983-01-14
GB2022090A (en) 1979-12-12
IS1203B6 (en) 1986-03-24
NO791776L (en) 1979-12-03
GB2099418A (en) 1982-12-08
DD143911A5 (en) 1980-09-17
CS219254B2 (en) 1983-03-25
PT69698A (en) 1979-06-01
YU42485B (en) 1988-10-31
FR2427337A1 (en) 1979-12-28
IL57392A0 (en) 1979-09-30
HK31383A (en) 1983-09-02
ATE7229T1 (en) 1984-05-15
SE7904682L (en) 1979-12-01
FR2509312B1 (en) 1984-06-29
CU35088A (en) 1982-08-24
DK149282B (en) 1986-04-21
DE2966946D1 (en) 1984-05-30
SE437522B (en) 1985-03-04
NL7904083A (en) 1979-12-04
JPS6016994A (en) 1985-01-28
EP0045525A3 (en) 1982-02-17
MY8400127A (en) 1984-12-31
YU45256B (en) 1992-05-28
IE791041L (en) 1979-11-30

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