AU4736679A - Cephalosporin derivatives - Google Patents

Cephalosporin derivatives

Info

Publication number
AU4736679A
AU4736679A AU47366/79A AU4736679A AU4736679A AU 4736679 A AU4736679 A AU 4736679A AU 47366/79 A AU47366/79 A AU 47366/79A AU 4736679 A AU4736679 A AU 4736679A AU 4736679 A AU4736679 A AU 4736679A
Authority
AU
Australia
Prior art keywords
triazin
methyl
group
cephalosporin derivatives
dioxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU47366/79A
Other versions
AU524230C (en
AU524230B2 (en
Inventor
Marc Montavon
Roland Reiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH588278A external-priority patent/CH641468A5/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU4736679A publication Critical patent/AU4736679A/en
Application granted granted Critical
Publication of AU524230B2 publication Critical patent/AU524230B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE & CO.
Publication of AU524230C publication Critical patent/AU524230C/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Mutual Connection Of Rods And Tubes (AREA)
  • Reinforcement Elements For Buildings (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds of the general formula <IMAGE> [wherein X represents the 1,2,5,6- tetrahydro-2-methyl-5,6-dioxo-as- triazin-3-yl group, the 2,5-dihydro-6- hydroxy-2-methyl-5-oxo-as-triazin-3- yl group of the 1,4,5,6-tetrahydro-4- methyl-5,6-dioxo-as-triazin-3-yl group] and readily hydrolysable esters, readily hydrolysable ethers and salts thereof and hydrates of these compounds have broad-spectrum anti-bacterial activity.
AU47366/79A 1978-05-30 1979-05-23 Cephalosporin derivatives Expired AU524230C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH588278A CH641468A5 (en) 1978-05-30 1978-05-30 CEPHEM DERIVATIVES.
CH588278 1978-05-30
CH224879 1979-03-08
CH224879 1979-03-08

Publications (3)

Publication Number Publication Date
AU4736679A true AU4736679A (en) 1979-12-06
AU524230B2 AU524230B2 (en) 1982-09-09
AU524230C AU524230C (en) 1994-10-06

Family

ID=

Also Published As

Publication number Publication date
DE2922036C2 (en) 1983-02-17
EP0005830B1 (en) 1982-09-22
FI65434C (en) 1984-05-10
PL215972A1 (en) 1980-02-11
GR72242B (en) 1983-10-04
JPS613795B2 (en) 1986-02-04
IT1121517B (en) 1986-04-02
IL57392A (en) 1982-05-31
FI65434B (en) 1984-01-31
DD143911A5 (en) 1980-09-17
ES488687A0 (en) 1980-12-16
DE2963720D1 (en) 1982-11-04
EG14153A (en) 1983-03-31
DK149282C (en) 1986-09-01
LU81325A1 (en) 1980-12-16
YU74485A (en) 1987-12-31
MY8400127A (en) 1984-12-31
DE2922036A1 (en) 1979-12-06
JPS613355B2 (en) 1986-01-31
ES8101606A1 (en) 1980-12-16
HK31383A (en) 1983-09-02
IE791041L (en) 1979-11-30
MC1259A1 (en) 1980-01-14
RO77560A (en) 1982-04-12
FR2509312B1 (en) 1984-06-29
DE2954159C2 (en) 1983-10-06
KE3268A (en) 1983-05-13
YU45257B (en) 1992-05-28
BR7903368A (en) 1979-12-11
MTP845B (en) 1980-07-21
SE7904682L (en) 1979-12-01
NO159797C (en) 1989-02-08
YU74585A (en) 1987-12-31
IS1203B6 (en) 1986-03-24
IS2490A7 (en) 1979-12-01
CU35088A (en) 1982-08-24
ATA390479A (en) 1981-12-15
SG10483G (en) 1983-12-16
NL7904083A (en) 1979-12-04
JPS54157596A (en) 1979-12-12
AT367764B (en) 1982-07-26
HU183089B (en) 1984-04-28
NZ190532A (en) 1983-03-15
EP0045525A3 (en) 1982-02-17
AU524230B2 (en) 1982-09-09
PL122458B1 (en) 1982-07-31
FR2509312A1 (en) 1983-01-14
GB2022090A (en) 1979-12-12
IL57392A0 (en) 1979-09-30
PH15148A (en) 1982-08-24
SE437522B (en) 1985-03-04
FR2427337A1 (en) 1979-12-28
IE49047B1 (en) 1985-07-24
DK149282B (en) 1986-04-21
YU45256B (en) 1992-05-28
GB2022090B (en) 1982-12-15
YU42485B (en) 1988-10-31
EP0005830A1 (en) 1979-12-12
DE2966946D1 (en) 1984-05-30
ATE1586T1 (en) 1982-10-15
FI791703A (en) 1979-12-01
IT7923049A0 (en) 1979-05-28
PT69698A (en) 1979-06-01
EP0045525A2 (en) 1982-02-10
GB2099418A (en) 1982-12-08
CA1141373A (en) 1983-02-15
DK222679A (en) 1979-12-01
CS219254B2 (en) 1983-03-25
ATE7229T1 (en) 1984-05-15
GB2099418B (en) 1983-06-02
BG50163A3 (en) 1992-05-15
CY1182A (en) 1983-10-07
YU123379A (en) 1983-04-30
OA06263A (en) 1981-06-30
ES480990A1 (en) 1980-08-16
NO159797B (en) 1988-10-31
NO791776L (en) 1979-12-03
JPS6016994A (en) 1985-01-28
EP0045525B1 (en) 1984-04-25

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