AU524230B2 - Cephalosporin derivatives - Google Patents

Cephalosporin derivatives

Info

Publication number
AU524230B2
AU524230B2 AU47366/79A AU4736679A AU524230B2 AU 524230 B2 AU524230 B2 AU 524230B2 AU 47366/79 A AU47366/79 A AU 47366/79A AU 4736679 A AU4736679 A AU 4736679A AU 524230 B2 AU524230 B2 AU 524230B2
Authority
AU
Australia
Prior art keywords
triazin
methyl
group
cephalosporin derivatives
dioxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU47366/79A
Other versions
AU524230C (en
AU4736679A (en
Inventor
Marc Montavon
Roland Reiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH588278A external-priority patent/CH641468A5/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU4736679A publication Critical patent/AU4736679A/en
Application granted granted Critical
Publication of AU524230B2 publication Critical patent/AU524230B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE & CO.
Publication of AU524230C publication Critical patent/AU524230C/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Reinforcement Elements For Buildings (AREA)
  • Mutual Connection Of Rods And Tubes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Compounds of the general formula <IMAGE> [wherein X represents the 1,2,5,6- tetrahydro-2-methyl-5,6-dioxo-as- triazin-3-yl group, the 2,5-dihydro-6- hydroxy-2-methyl-5-oxo-as-triazin-3- yl group of the 1,4,5,6-tetrahydro-4- methyl-5,6-dioxo-as-triazin-3-yl group] and readily hydrolysable esters, readily hydrolysable ethers and salts thereof and hydrates of these compounds have broad-spectrum anti-bacterial activity.
AU47366/79A 1978-05-30 1979-05-23 Cephalosporin derivatives Expired AU524230C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH588278 1978-05-30
CH588278A CH641468A5 (en) 1978-05-30 1978-05-30 CEPHEM DERIVATIVES.
CH224879 1979-03-08
CH224879 1979-03-08

Publications (3)

Publication Number Publication Date
AU4736679A AU4736679A (en) 1979-12-06
AU524230B2 true AU524230B2 (en) 1982-09-09
AU524230C AU524230C (en) 1994-10-06

Family

ID=

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2271877A (en) * 1976-04-12 1978-08-31 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2271877A (en) * 1976-04-12 1978-08-31 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds

Also Published As

Publication number Publication date
MTP845B (en) 1980-07-21
CA1141373A (en) 1983-02-15
YU123379A (en) 1983-04-30
EP0045525B1 (en) 1984-04-25
EG14153A (en) 1983-03-31
SG10483G (en) 1983-12-16
BR7903368A (en) 1979-12-11
GB2022090B (en) 1982-12-15
YU74485A (en) 1987-12-31
JPS613795B2 (en) 1986-02-04
RO77560A (en) 1982-04-12
IS2490A7 (en) 1979-12-01
ATE1586T1 (en) 1982-10-15
EP0005830A1 (en) 1979-12-12
OA06263A (en) 1981-06-30
DE2954159C2 (en) 1983-10-06
PL122458B1 (en) 1982-07-31
IT7923049A0 (en) 1979-05-28
NZ190532A (en) 1983-03-15
NO159797B (en) 1988-10-31
GB2099418B (en) 1983-06-02
JPS613355B2 (en) 1986-01-31
ES480990A1 (en) 1980-08-16
JPS54157596A (en) 1979-12-12
MC1259A1 (en) 1980-01-14
FI791703A (en) 1979-12-01
AU4736679A (en) 1979-12-06
BG50163A3 (en) 1992-05-15
ES8101606A1 (en) 1980-12-16
DE2922036A1 (en) 1979-12-06
LU81325A1 (en) 1980-12-16
YU74585A (en) 1987-12-31
DE2922036C2 (en) 1983-02-17
EP0045525A2 (en) 1982-02-10
PL215972A1 (en) 1980-02-11
DE2963720D1 (en) 1982-11-04
IL57392A (en) 1982-05-31
FI65434C (en) 1984-05-10
EP0005830B1 (en) 1982-09-22
NO159797C (en) 1989-02-08
CY1182A (en) 1983-10-07
AT367764B (en) 1982-07-26
IE49047B1 (en) 1985-07-24
IT1121517B (en) 1986-04-02
KE3268A (en) 1983-05-13
ATA390479A (en) 1981-12-15
DK149282C (en) 1986-09-01
YU45257B (en) 1992-05-28
ES488687A0 (en) 1980-12-16
FI65434B (en) 1984-01-31
HU183089B (en) 1984-04-28
GR72242B (en) 1983-10-04
PH15148A (en) 1982-08-24
DK222679A (en) 1979-12-01
FR2509312A1 (en) 1983-01-14
GB2022090A (en) 1979-12-12
IS1203B6 (en) 1986-03-24
NO791776L (en) 1979-12-03
GB2099418A (en) 1982-12-08
DD143911A5 (en) 1980-09-17
CS219254B2 (en) 1983-03-25
PT69698A (en) 1979-06-01
YU42485B (en) 1988-10-31
FR2427337A1 (en) 1979-12-28
IL57392A0 (en) 1979-09-30
HK31383A (en) 1983-09-02
ATE7229T1 (en) 1984-05-15
SE7904682L (en) 1979-12-01
FR2509312B1 (en) 1984-06-29
CU35088A (en) 1982-08-24
DK149282B (en) 1986-04-21
DE2966946D1 (en) 1984-05-30
SE437522B (en) 1985-03-04
NL7904083A (en) 1979-12-04
JPS6016994A (en) 1985-01-28
EP0045525A3 (en) 1982-02-17
MY8400127A (en) 1984-12-31
YU45256B (en) 1992-05-28
IE791041L (en) 1979-11-30

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