NO791776L - ACYL DERIVATIVES. - Google Patents

ACYL DERIVATIVES.

Info

Publication number
NO791776L
NO791776L NO791776A NO791776A NO791776L NO 791776 L NO791776 L NO 791776L NO 791776 A NO791776 A NO 791776A NO 791776 A NO791776 A NO 791776A NO 791776 L NO791776 L NO 791776L
Authority
NO
Norway
Prior art keywords
triazin
methyl
group
acyl derivatives
dioxo
Prior art date
Application number
NO791776A
Other languages
Norwegian (no)
Other versions
NO159797B (en
NO159797C (en
Inventor
Marc Montavon
Roland Reiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH588278A external-priority patent/CH641468A5/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO791776L publication Critical patent/NO791776L/en
Priority to NO823987A priority Critical patent/NO158346C/en
Priority to NO844103A priority patent/NO161221C/en
Priority to NO865360A priority patent/NO160301C/en
Publication of NO159797B publication Critical patent/NO159797B/en
Publication of NO159797C publication Critical patent/NO159797C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36Methylene radicals, substituted by sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Mutual Connection Of Rods And Tubes (AREA)
  • Reinforcement Elements For Buildings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Fats And Perfumes (AREA)

Abstract

Compounds of the general formula <IMAGE> [wherein X represents the 1,2,5,6- tetrahydro-2-methyl-5,6-dioxo-as- triazin-3-yl group, the 2,5-dihydro-6- hydroxy-2-methyl-5-oxo-as-triazin-3- yl group of the 1,4,5,6-tetrahydro-4- methyl-5,6-dioxo-as-triazin-3-yl group] and readily hydrolysable esters, readily hydrolysable ethers and salts thereof and hydrates of these compounds have broad-spectrum anti-bacterial activity.
NO791776A 1978-05-30 1979-05-29 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTIC ACTIVE CEPHALOSPORINALS. NO159797C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NO823987A NO158346C (en) 1978-05-30 1982-11-26 Cephalosporin.
NO844103A NO161221C (en) 1978-05-30 1984-10-12 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE CEPHALOSPORINE SALTS.
NO865360A NO160301C (en) 1978-05-30 1986-12-30 ANALOGY PROCEDURE FOR THE PREPARATION OF A THERAPEUTIC ACTIVE CEPHALOSPORIN SALT.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH588278A CH641468A5 (en) 1978-05-30 1978-05-30 CEPHEM DERIVATIVES.
CH224879 1979-03-08

Publications (3)

Publication Number Publication Date
NO791776L true NO791776L (en) 1979-12-03
NO159797B NO159797B (en) 1988-10-31
NO159797C NO159797C (en) 1989-02-08

Family

ID=25689901

Family Applications (1)

Application Number Title Priority Date Filing Date
NO791776A NO159797C (en) 1978-05-30 1979-05-29 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTIC ACTIVE CEPHALOSPORINALS.

Country Status (40)

Country Link
EP (2) EP0005830B1 (en)
JP (2) JPS54157596A (en)
AT (3) AT367764B (en)
BG (1) BG50163A3 (en)
BR (1) BR7903368A (en)
CA (1) CA1141373A (en)
CS (1) CS219254B2 (en)
CU (1) CU35088A (en)
CY (1) CY1182A (en)
DD (1) DD143911A5 (en)
DE (4) DE2922036C2 (en)
DK (1) DK149282C (en)
EG (1) EG14153A (en)
ES (2) ES480990A1 (en)
FI (1) FI65434C (en)
FR (2) FR2427337A1 (en)
GB (2) GB2099418B (en)
GR (1) GR72242B (en)
HK (1) HK31383A (en)
HU (1) HU183089B (en)
IE (1) IE49047B1 (en)
IL (1) IL57392A (en)
IS (1) IS1203B6 (en)
IT (1) IT1121517B (en)
KE (1) KE3268A (en)
LU (1) LU81325A1 (en)
MC (1) MC1259A1 (en)
MT (1) MTP845B (en)
MY (1) MY8400127A (en)
NL (1) NL7904083A (en)
NO (1) NO159797C (en)
NZ (1) NZ190532A (en)
OA (1) OA06263A (en)
PH (1) PH15148A (en)
PL (1) PL122458B1 (en)
PT (1) PT69698A (en)
RO (1) RO77560A (en)
SE (1) SE437522B (en)
SG (1) SG10483G (en)
YU (3) YU42485B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI67385C (en) * 1979-11-21 1985-03-11 Hoffmann La Roche PROCEDURE FOR FRAMSTATION OF AV (6R 7R) -7- (2- (2-AMINO-4-THIAZOLYL) -2- (Z-METHOXYIMINO) ACETAMIDO) -3-CEFEM-4-CARBOXYL SYRATER DERIVATIVES
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
CA1177823A (en) * 1980-03-25 1984-11-13 Andre Furlenmeier Cephalosporin derivatives
CA1154009A (en) * 1980-03-25 1983-09-20 Roland Reiner Cephalosporin derivatives
GR75711B (en) * 1980-06-30 1984-08-02 Sanofi Sa
US4308267A (en) 1980-07-03 1981-12-29 Smithkline Corporation 7-[2-Alkoxyimino-2-(amino-thiazole)acetamido]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins
DK379581A (en) * 1980-10-06 1982-04-07 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF ACYL DERIVATIVES
FR2494278A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0058250A3 (en) * 1981-02-17 1983-08-17 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporin derivatives, their preparation and pharmaceutical compositions containing them
EP0185220A3 (en) * 1984-12-19 1987-09-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Intermediates for the preparation of cephalosporins
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
RU2021274C1 (en) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Process for preparing aminothiazolyl cephalosporin derivatives
KR950014571B1 (en) * 1991-11-18 1995-12-08 제일제당주식회사 Process for the preparation of cephem derivatives
AT398764B (en) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih METHOD FOR PRODUCING CEFTRIAXONDINATRIUM SALZHEMIHEPTAHYDRATE
AT399877B (en) * 1992-02-20 1995-08-25 Biochemie Gmbh NEW METHOD FOR PRODUCING CEFTRIAXONE
KR100197788B1 (en) * 1995-06-30 1999-06-15 김충환 Processes for manufacturing cephem derivatives
DE102011117421A1 (en) 2011-11-02 2013-05-02 Hans-Peter Gabel Pharmaceutical composition useful for treating Lyme disease, comprises mixture of active substances including ceftriaxone and cefotaxime
RU2504548C1 (en) * 2012-09-28 2014-01-20 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) DERIVATIVE OF β-LACTAM CEFTRIAXONE ANTIBIOTIC

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH609989A5 (en) * 1974-06-21 1979-03-30 Hoffmann La Roche Process for the preparation of acyl derivatives
CA1100129A (en) * 1974-08-02 1981-04-28 William H.W. Lunn Cephalosporin compounds
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
DK162391C (en) 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
DE2760484C2 (en) 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
JPS5329936A (en) * 1976-08-31 1978-03-20 Takeda Chem Ind Ltd Antibiotic composition
NL7805715A (en) * 1977-06-03 1978-12-05 Hoffmann La Roche METHOD FOR PREPARING ACYL DERIVATIVES.
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins

Also Published As

Publication number Publication date
EP0005830A1 (en) 1979-12-12
SG10483G (en) 1983-12-16
JPS613795B2 (en) 1986-02-04
AU524230B2 (en) 1982-09-09
IL57392A (en) 1982-05-31
GB2022090B (en) 1982-12-15
ATE7229T1 (en) 1984-05-15
ES480990A1 (en) 1980-08-16
MY8400127A (en) 1984-12-31
GB2099418B (en) 1983-06-02
DE2922036C2 (en) 1983-02-17
FR2509312B1 (en) 1984-06-29
IS2490A7 (en) 1979-12-01
DE2954159C2 (en) 1983-10-06
CU35088A (en) 1982-08-24
NL7904083A (en) 1979-12-04
ATA390479A (en) 1981-12-15
RO77560A (en) 1982-04-12
IT1121517B (en) 1986-04-02
PT69698A (en) 1979-06-01
NO159797B (en) 1988-10-31
FI65434B (en) 1984-01-31
FI65434C (en) 1984-05-10
EP0045525B1 (en) 1984-04-25
DK222679A (en) 1979-12-01
YU123379A (en) 1983-04-30
PL122458B1 (en) 1982-07-31
JPS613355B2 (en) 1986-01-31
DK149282C (en) 1986-09-01
IE49047B1 (en) 1985-07-24
GR72242B (en) 1983-10-04
CA1141373A (en) 1983-02-15
DD143911A5 (en) 1980-09-17
EP0045525A3 (en) 1982-02-17
YU74585A (en) 1987-12-31
AT367764B (en) 1982-07-26
HU183089B (en) 1984-04-28
ES8101606A1 (en) 1980-12-16
ES488687A0 (en) 1980-12-16
ATE1586T1 (en) 1982-10-15
PH15148A (en) 1982-08-24
CY1182A (en) 1983-10-07
DE2922036A1 (en) 1979-12-06
DE2963720D1 (en) 1982-11-04
FI791703A (en) 1979-12-01
NZ190532A (en) 1983-03-15
IT7923049A0 (en) 1979-05-28
IE791041L (en) 1979-11-30
MTP845B (en) 1980-07-21
IS1203B6 (en) 1986-03-24
OA06263A (en) 1981-06-30
BR7903368A (en) 1979-12-11
MC1259A1 (en) 1980-01-14
LU81325A1 (en) 1980-12-16
GB2099418A (en) 1982-12-08
FR2509312A1 (en) 1983-01-14
GB2022090A (en) 1979-12-12
DE2966946D1 (en) 1984-05-30
CS219254B2 (en) 1983-03-25
SE437522B (en) 1985-03-04
JPS6016994A (en) 1985-01-28
YU74485A (en) 1987-12-31
YU45256B (en) 1992-05-28
IL57392A0 (en) 1979-09-30
YU42485B (en) 1988-10-31
EG14153A (en) 1983-03-31
DK149282B (en) 1986-04-21
JPS54157596A (en) 1979-12-12
FR2427337A1 (en) 1979-12-28
YU45257B (en) 1992-05-28
EP0005830B1 (en) 1982-09-22
NO159797C (en) 1989-02-08
EP0045525A2 (en) 1982-02-10
SE7904682L (en) 1979-12-01
KE3268A (en) 1983-05-13
HK31383A (en) 1983-09-02
BG50163A3 (en) 1992-05-15
PL215972A1 (en) 1980-02-11
AU4736679A (en) 1979-12-06

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NO791776L (en) ACYL DERIVATIVES.