YU42485B - Process for obtaining cephalosporin derivatives - Google Patents

Process for obtaining cephalosporin derivatives

Info

Publication number
YU42485B
YU42485B YU1233/79A YU123379A YU42485B YU 42485 B YU42485 B YU 42485B YU 1233/79 A YU1233/79 A YU 1233/79A YU 123379 A YU123379 A YU 123379A YU 42485 B YU42485 B YU 42485B
Authority
YU
Yugoslavia
Prior art keywords
triazin
methyl
group
cephalosporin derivatives
dioxo
Prior art date
Application number
YU1233/79A
Other versions
YU123379A (en
Inventor
M Montavon
R Reiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH588278A external-priority patent/CH641468A5/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to SI7911233A priority Critical patent/SI7911233A8/en
Publication of YU123379A publication Critical patent/YU123379A/en
Publication of YU42485B publication Critical patent/YU42485B/en
Priority to HRP-1233/79A priority patent/HRP930529B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Reinforcement Elements For Buildings (AREA)
  • Mutual Connection Of Rods And Tubes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Compounds of the general formula <IMAGE> [wherein X represents the 1,2,5,6- tetrahydro-2-methyl-5,6-dioxo-as- triazin-3-yl group, the 2,5-dihydro-6- hydroxy-2-methyl-5-oxo-as-triazin-3- yl group of the 1,4,5,6-tetrahydro-4- methyl-5,6-dioxo-as-triazin-3-yl group] and readily hydrolysable esters, readily hydrolysable ethers and salts thereof and hydrates of these compounds have broad-spectrum anti-bacterial activity.
YU1233/79A 1978-05-30 1979-05-25 Process for obtaining cephalosporin derivatives YU42485B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI7911233A SI7911233A8 (en) 1978-05-30 1979-05-25 Process for preparing of cephalosporine derivates
HRP-1233/79A HRP930529B1 (en) 1978-05-30 1993-03-26 Process for the preparation of cephalosphorine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH588278A CH641468A5 (en) 1978-05-30 1978-05-30 CEPHEM DERIVATIVES.
CH224879 1979-03-08

Publications (2)

Publication Number Publication Date
YU123379A YU123379A (en) 1983-04-30
YU42485B true YU42485B (en) 1988-10-31

Family

ID=25689901

Family Applications (3)

Application Number Title Priority Date Filing Date
YU1233/79A YU42485B (en) 1978-05-30 1979-05-25 Process for obtaining cephalosporin derivatives
YU744/85A YU45256B (en) 1978-05-30 1985-05-06 Process for obtaining derivatives of cephalosporine
YU745/85A YU45257B (en) 1978-05-30 1985-05-06 Process for obtaining salt-hydrates derivatives of cephalosporine

Family Applications After (2)

Application Number Title Priority Date Filing Date
YU744/85A YU45256B (en) 1978-05-30 1985-05-06 Process for obtaining derivatives of cephalosporine
YU745/85A YU45257B (en) 1978-05-30 1985-05-06 Process for obtaining salt-hydrates derivatives of cephalosporine

Country Status (40)

Country Link
EP (2) EP0005830B1 (en)
JP (2) JPS54157596A (en)
AT (3) AT367764B (en)
BG (1) BG50163A3 (en)
BR (1) BR7903368A (en)
CA (1) CA1141373A (en)
CS (1) CS219254B2 (en)
CU (1) CU35088A (en)
CY (1) CY1182A (en)
DD (1) DD143911A5 (en)
DE (4) DE2963720D1 (en)
DK (1) DK149282C (en)
EG (1) EG14153A (en)
ES (2) ES480990A1 (en)
FI (1) FI65434C (en)
FR (2) FR2427337A1 (en)
GB (2) GB2099418B (en)
GR (1) GR72242B (en)
HK (1) HK31383A (en)
HU (1) HU183089B (en)
IE (1) IE49047B1 (en)
IL (1) IL57392A (en)
IS (1) IS1203B6 (en)
IT (1) IT1121517B (en)
KE (1) KE3268A (en)
LU (1) LU81325A1 (en)
MC (1) MC1259A1 (en)
MT (1) MTP845B (en)
MY (1) MY8400127A (en)
NL (1) NL7904083A (en)
NO (1) NO159797C (en)
NZ (1) NZ190532A (en)
OA (1) OA06263A (en)
PH (1) PH15148A (en)
PL (1) PL122458B1 (en)
PT (1) PT69698A (en)
RO (1) RO77560A (en)
SE (1) SE437522B (en)
SG (1) SG10483G (en)
YU (3) YU42485B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI67385C (en) * 1979-11-21 1985-03-11 Hoffmann La Roche PROCEDURE FOR FRAMSTATION OF AV (6R 7R) -7- (2- (2-AMINO-4-THIAZOLYL) -2- (Z-METHOXYIMINO) ACETAMIDO) -3-CEFEM-4-CARBOXYL SYRATER DERIVATIVES
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
CA1154009A (en) * 1980-03-25 1983-09-20 Roland Reiner Cephalosporin derivatives
NZ196552A (en) * 1980-03-25 1984-07-06 Hoffmann La Roche Cephalosporin derivatives and pharmaceutical compositions;intermediate cephalosporins
GR75706B (en) * 1980-06-30 1984-08-02 Sanofi Sa
US4308267A (en) 1980-07-03 1981-12-29 Smithkline Corporation 7-[2-Alkoxyimino-2-(amino-thiazole)acetamido]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins
DK379581A (en) * 1980-10-06 1982-04-07 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF ACYL DERIVATIVES
FR2494278A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0058250A3 (en) * 1981-02-17 1983-08-17 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporin derivatives, their preparation and pharmaceutical compositions containing them
EP0185220A3 (en) * 1984-12-19 1987-09-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Intermediates for the preparation of cephalosporins
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
RU2021274C1 (en) 1991-05-17 1994-10-15 Польска Акадэмия Наук Институт Хэмии Органичнэй Process for preparing aminothiazolyl cephalosporin derivatives
KR950014571B1 (en) * 1991-11-18 1995-12-08 제일제당주식회사 Process for the preparation of cephem derivatives
AT398764B (en) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih METHOD FOR PRODUCING CEFTRIAXONDINATRIUM SALZHEMIHEPTAHYDRATE
AT399877B (en) * 1992-02-20 1995-08-25 Biochemie Gmbh NEW METHOD FOR PRODUCING CEFTRIAXONE
KR100197788B1 (en) * 1995-06-30 1999-06-15 김충환 Processes for manufacturing cephem derivatives
DE102011117421A1 (en) 2011-11-02 2013-05-02 Hans-Peter Gabel Pharmaceutical composition useful for treating Lyme disease, comprises mixture of active substances including ceftriaxone and cefotaxime
RU2504548C1 (en) * 2012-09-28 2014-01-20 Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" (Сфу) DERIVATIVE OF β-LACTAM CEFTRIAXONE ANTIBIOTIC

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH609989A5 (en) * 1974-06-21 1979-03-30 Hoffmann La Roche Process for the preparation of acyl derivatives
CA1100129A (en) * 1974-08-02 1981-04-28 William H.W. Lunn Cephalosporin compounds
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
DK162391C (en) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
GR63088B (en) 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
JPS5329936A (en) * 1976-08-31 1978-03-20 Takeda Chem Ind Ltd Antibiotic composition
NL7805715A (en) * 1977-06-03 1978-12-05 Hoffmann La Roche METHOD FOR PREPARING ACYL DERIVATIVES.
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins

Also Published As

Publication number Publication date
MTP845B (en) 1980-07-21
CA1141373A (en) 1983-02-15
YU123379A (en) 1983-04-30
EP0045525B1 (en) 1984-04-25
EG14153A (en) 1983-03-31
SG10483G (en) 1983-12-16
BR7903368A (en) 1979-12-11
GB2022090B (en) 1982-12-15
YU74485A (en) 1987-12-31
JPS613795B2 (en) 1986-02-04
RO77560A (en) 1982-04-12
IS2490A7 (en) 1979-12-01
ATE1586T1 (en) 1982-10-15
EP0005830A1 (en) 1979-12-12
OA06263A (en) 1981-06-30
DE2954159C2 (en) 1983-10-06
PL122458B1 (en) 1982-07-31
IT7923049A0 (en) 1979-05-28
NZ190532A (en) 1983-03-15
NO159797B (en) 1988-10-31
GB2099418B (en) 1983-06-02
JPS613355B2 (en) 1986-01-31
ES480990A1 (en) 1980-08-16
JPS54157596A (en) 1979-12-12
MC1259A1 (en) 1980-01-14
FI791703A (en) 1979-12-01
AU4736679A (en) 1979-12-06
BG50163A3 (en) 1992-05-15
ES8101606A1 (en) 1980-12-16
DE2922036A1 (en) 1979-12-06
LU81325A1 (en) 1980-12-16
YU74585A (en) 1987-12-31
DE2922036C2 (en) 1983-02-17
EP0045525A2 (en) 1982-02-10
PL215972A1 (en) 1980-02-11
DE2963720D1 (en) 1982-11-04
IL57392A (en) 1982-05-31
FI65434C (en) 1984-05-10
EP0005830B1 (en) 1982-09-22
NO159797C (en) 1989-02-08
CY1182A (en) 1983-10-07
AT367764B (en) 1982-07-26
IE49047B1 (en) 1985-07-24
IT1121517B (en) 1986-04-02
KE3268A (en) 1983-05-13
ATA390479A (en) 1981-12-15
AU524230B2 (en) 1982-09-09
DK149282C (en) 1986-09-01
YU45257B (en) 1992-05-28
ES488687A0 (en) 1980-12-16
FI65434B (en) 1984-01-31
HU183089B (en) 1984-04-28
GR72242B (en) 1983-10-04
PH15148A (en) 1982-08-24
DK222679A (en) 1979-12-01
FR2509312A1 (en) 1983-01-14
GB2022090A (en) 1979-12-12
IS1203B6 (en) 1986-03-24
NO791776L (en) 1979-12-03
GB2099418A (en) 1982-12-08
DD143911A5 (en) 1980-09-17
CS219254B2 (en) 1983-03-25
PT69698A (en) 1979-06-01
FR2427337A1 (en) 1979-12-28
IL57392A0 (en) 1979-09-30
HK31383A (en) 1983-09-02
ATE7229T1 (en) 1984-05-15
SE7904682L (en) 1979-12-01
FR2509312B1 (en) 1984-06-29
CU35088A (en) 1982-08-24
DK149282B (en) 1986-04-21
DE2966946D1 (en) 1984-05-30
SE437522B (en) 1985-03-04
NL7904083A (en) 1979-12-04
JPS6016994A (en) 1985-01-28
EP0045525A3 (en) 1982-02-17
MY8400127A (en) 1984-12-31
YU45256B (en) 1992-05-28
IE791041L (en) 1979-11-30

Similar Documents

Publication Publication Date Title
YU42485B (en) Process for obtaining cephalosporin derivatives