JPS57159789A - Preparation of cephamycin derivative - Google Patents

Preparation of cephamycin derivative

Info

Publication number
JPS57159789A
JPS57159789A JP4485481A JP4485481A JPS57159789A JP S57159789 A JPS57159789 A JP S57159789A JP 4485481 A JP4485481 A JP 4485481A JP 4485481 A JP4485481 A JP 4485481A JP S57159789 A JPS57159789 A JP S57159789A
Authority
JP
Japan
Prior art keywords
cephamycin
compound
hetero
halogen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4485481A
Other languages
Japanese (ja)
Other versions
JPH0158189B2 (en
Inventor
Junichi Nakazawa
Masanao Kaneko
Takeo Miyaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP4485481A priority Critical patent/JPS57159789A/en
Priority to SE8201087A priority patent/SE452620B/en
Priority to CH108282A priority patent/CH646977A5/en
Priority to DK075582A priority patent/DK162603C/en
Priority to CA000396796A priority patent/CA1194470A/en
Priority to ES509837A priority patent/ES8305362A1/en
Priority to FI820582A priority patent/FI72521C/en
Priority to NL8200708A priority patent/NL8200708A/en
Priority to IT67194/82A priority patent/IT1157951B/en
Publication of JPS57159789A publication Critical patent/JPS57159789A/en
Publication of JPH0158189B2 publication Critical patent/JPH0158189B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the titled compound useful as an intermediate of antibacterial agent, easily, economically, in an idustrial scale, in high yield, by reacting a specific cephamycin C with a carboxylic acid halide in a halogenated hydrocarbon solvent, thereby carrying out the acyl exchange reaction continuously.
CONSTITUTION: The compound of formulaI{R1 is amino protected with electrophilic group; R2 is H or halogen; R3 is hetero-ring group[hetero-ring is (substituted) 1H-tetrazol-5-yl, (substituted) 1,3,4-thiadiazol-2-yl, etc.]}is made to react with the compound of formula R4-X (R4 is acyl; X is halogen) is a halogenated hydrocarbon solvent to obtain the cephamycin derivative of formula II. The solvent is preferably dichloromethane, chloroform, or especially, 1,2-dichloroethane.
COPYRIGHT: (C)1982,JPO&Japio
JP4485481A 1981-02-23 1981-03-27 Preparation of cephamycin derivative Granted JPS57159789A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP4485481A JPS57159789A (en) 1981-03-27 1981-03-27 Preparation of cephamycin derivative
SE8201087A SE452620B (en) 1981-02-23 1982-02-22 PROCEDURE FOR THE PREPARATION OF BETA-LACTIC ANTIBIOTICS DERIVATIVES
CH108282A CH646977A5 (en) 1981-02-23 1982-02-22 Process for the preparation of derivatives of beta-lactam antibiotics
DK075582A DK162603C (en) 1981-02-23 1982-02-22 PROCEDURE FOR PREPARING BETA-LACTAM ANTIBIOTICA
CA000396796A CA1194470A (en) 1981-02-23 1982-02-23 PROCESS FOR PREPARING DERIVATIVES OF .beta.-LACTAM ANTI- BIOTICS
ES509837A ES8305362A1 (en) 1981-02-23 1982-02-23 A procedure for preparing derivatives of antibioticos-lactamicos. (Machine-translation by Google Translate, not legally binding)
FI820582A FI72521C (en) 1981-02-23 1982-02-23 Process for the preparation of cephalosporin derivatives.
NL8200708A NL8200708A (en) 1981-02-23 1982-02-23 PROCESS FOR THE PREPARATION OF BETA-LACTAMANTIBIOTIC COMPOUNDS.
IT67194/82A IT1157951B (en) 1981-02-23 1982-02-23 PROCEDURE FOR THE PREPARATION OF BETALACTAMIC ANTIBIOTICS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4485481A JPS57159789A (en) 1981-03-27 1981-03-27 Preparation of cephamycin derivative

Publications (2)

Publication Number Publication Date
JPS57159789A true JPS57159789A (en) 1982-10-01
JPH0158189B2 JPH0158189B2 (en) 1989-12-11

Family

ID=12703064

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4485481A Granted JPS57159789A (en) 1981-02-23 1981-03-27 Preparation of cephamycin derivative

Country Status (1)

Country Link
JP (1) JPS57159789A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5520723A (en) * 1978-08-02 1980-02-14 Nippon Kayaku Co Ltd Preparation of cephalosporin compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5520723A (en) * 1978-08-02 1980-02-14 Nippon Kayaku Co Ltd Preparation of cephalosporin compound

Also Published As

Publication number Publication date
JPH0158189B2 (en) 1989-12-11

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