JPS57159789A - Preparation of cephamycin derivative - Google Patents
Preparation of cephamycin derivativeInfo
- Publication number
- JPS57159789A JPS57159789A JP4485481A JP4485481A JPS57159789A JP S57159789 A JPS57159789 A JP S57159789A JP 4485481 A JP4485481 A JP 4485481A JP 4485481 A JP4485481 A JP 4485481A JP S57159789 A JPS57159789 A JP S57159789A
- Authority
- JP
- Japan
- Prior art keywords
- cephamycin
- compound
- hetero
- halogen
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate of antibacterial agent, easily, economically, in an idustrial scale, in high yield, by reacting a specific cephamycin C with a carboxylic acid halide in a halogenated hydrocarbon solvent, thereby carrying out the acyl exchange reaction continuously.
CONSTITUTION: The compound of formulaI{R1 is amino protected with electrophilic group; R2 is H or halogen; R3 is hetero-ring group[hetero-ring is (substituted) 1H-tetrazol-5-yl, (substituted) 1,3,4-thiadiazol-2-yl, etc.]}is made to react with the compound of formula R4-X (R4 is acyl; X is halogen) is a halogenated hydrocarbon solvent to obtain the cephamycin derivative of formula II. The solvent is preferably dichloromethane, chloroform, or especially, 1,2-dichloroethane.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4485481A JPS57159789A (en) | 1981-03-27 | 1981-03-27 | Preparation of cephamycin derivative |
SE8201087A SE452620B (en) | 1981-02-23 | 1982-02-22 | PROCEDURE FOR THE PREPARATION OF BETA-LACTIC ANTIBIOTICS DERIVATIVES |
CH108282A CH646977A5 (en) | 1981-02-23 | 1982-02-22 | Process for the preparation of derivatives of beta-lactam antibiotics |
DK075582A DK162603C (en) | 1981-02-23 | 1982-02-22 | PROCEDURE FOR PREPARING BETA-LACTAM ANTIBIOTICA |
CA000396796A CA1194470A (en) | 1981-02-23 | 1982-02-23 | PROCESS FOR PREPARING DERIVATIVES OF .beta.-LACTAM ANTI- BIOTICS |
ES509837A ES8305362A1 (en) | 1981-02-23 | 1982-02-23 | A procedure for preparing derivatives of antibioticos-lactamicos. (Machine-translation by Google Translate, not legally binding) |
FI820582A FI72521C (en) | 1981-02-23 | 1982-02-23 | Process for the preparation of cephalosporin derivatives. |
NL8200708A NL8200708A (en) | 1981-02-23 | 1982-02-23 | PROCESS FOR THE PREPARATION OF BETA-LACTAMANTIBIOTIC COMPOUNDS. |
IT67194/82A IT1157951B (en) | 1981-02-23 | 1982-02-23 | PROCEDURE FOR THE PREPARATION OF BETALACTAMIC ANTIBIOTICS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4485481A JPS57159789A (en) | 1981-03-27 | 1981-03-27 | Preparation of cephamycin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57159789A true JPS57159789A (en) | 1982-10-01 |
JPH0158189B2 JPH0158189B2 (en) | 1989-12-11 |
Family
ID=12703064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4485481A Granted JPS57159789A (en) | 1981-02-23 | 1981-03-27 | Preparation of cephamycin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57159789A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5520723A (en) * | 1978-08-02 | 1980-02-14 | Nippon Kayaku Co Ltd | Preparation of cephalosporin compound |
-
1981
- 1981-03-27 JP JP4485481A patent/JPS57159789A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5520723A (en) * | 1978-08-02 | 1980-02-14 | Nippon Kayaku Co Ltd | Preparation of cephalosporin compound |
Also Published As
Publication number | Publication date |
---|---|
JPH0158189B2 (en) | 1989-12-11 |
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