JPS5640689A - Preparation of benzylpenicillin derivative or its salt - Google Patents

Preparation of benzylpenicillin derivative or its salt

Info

Publication number
JPS5640689A
JPS5640689A JP11611079A JP11611079A JPS5640689A JP S5640689 A JPS5640689 A JP S5640689A JP 11611079 A JP11611079 A JP 11611079A JP 11611079 A JP11611079 A JP 11611079A JP S5640689 A JPS5640689 A JP S5640689A
Authority
JP
Japan
Prior art keywords
formula
compound
derivative
benzylpenicillin
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11611079A
Other languages
Japanese (ja)
Inventor
Nobuhiro Oi
Bunya Aoki
Teizo Shinozaki
Kanji Moro
Isao Matsunaga
Takao Nofuji
Toshiyuki Nehashi
Yusuke Harada
Hisao Endo
Takao Kimura
Hiroshi Okazaki
Haruki Ogawa
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP11611079A priority Critical patent/JPS5640689A/en
Publication of JPS5640689A publication Critical patent/JPS5640689A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as an antibacterial agent, by reacting an α-aminobenzylpenicillin with a benzoyl isocyanate or a benzoylcarbamic acid halide.
CONSTITUTION: The titled compound of formula IV (R11 is lower alkyl; R2 is H or OH; R3 are 2W3 lower alkanoyloxy groups, at least two of which are adjacent) can be prepared by reacting a compound of formula I or its reactive derivative with a compound of formula II or formula III (X is halogen) in a solvent such as dichloromethane at -30W35°C, pref. -10W20°C. The compound of formula IV thus prepared is an excellent antibacterial agent easpecially effective to the bacteria belonging to Pseudomonas genus.
COPYRIGHT: (C)1981,JPO&Japio
JP11611079A 1979-09-12 1979-09-12 Preparation of benzylpenicillin derivative or its salt Pending JPS5640689A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11611079A JPS5640689A (en) 1979-09-12 1979-09-12 Preparation of benzylpenicillin derivative or its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11611079A JPS5640689A (en) 1979-09-12 1979-09-12 Preparation of benzylpenicillin derivative or its salt

Publications (1)

Publication Number Publication Date
JPS5640689A true JPS5640689A (en) 1981-04-16

Family

ID=14678932

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11611079A Pending JPS5640689A (en) 1979-09-12 1979-09-12 Preparation of benzylpenicillin derivative or its salt

Country Status (1)

Country Link
JP (1) JPS5640689A (en)

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