JPS5762289A - Preparation of 3-thiomethyl derivative from 7-acylaminocephalosporanic acid - Google Patents
Preparation of 3-thiomethyl derivative from 7-acylaminocephalosporanic acidInfo
- Publication number
- JPS5762289A JPS5762289A JP6453981A JP6453981A JPS5762289A JP S5762289 A JPS5762289 A JP S5762289A JP 6453981 A JP6453981 A JP 6453981A JP 6453981 A JP6453981 A JP 6453981A JP S5762289 A JPS5762289 A JP S5762289A
- Authority
- JP
- Japan
- Prior art keywords
- formulai
- compound
- preparation
- acid
- thiomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formulaI(X is imino, O or S; R is thiazolyl, triazolyl, diazolyl, etc.).
EXAMPLE: 7-[D-α-(4-Hydroxynicotinoylamido)-α-phenylacetamido]-3-(5--methyl- amino-1,3,4-thiadiazol-2-yl)thiomethyl-Δ3-cephem-4-carboxylic acid.
USE: An antimicrobial agent, effective against Gram-negative and Gram-positive bacteria, and capable of exhibiting remarkable effects particularly on Pseudomonas aeruginosa and myxomycetes.
PROCESS: A 7-acylaminocephalosporanic acid of formula II or a salt thereof is reacted with a thiol derivative of formula III or an alkaline metallic substitution product at the H of -SH group thereof to give the compound of formulaI. The reaction is preferably carried out in a solvent, e.g. acetone, under neutralWweakly alkaline conditions.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6453981A JPS5924159B2 (en) | 1981-04-28 | 1981-04-28 | Method for producing 3-thiomethyl derivative of 7-acylaminocephalosporanic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6453981A JPS5924159B2 (en) | 1981-04-28 | 1981-04-28 | Method for producing 3-thiomethyl derivative of 7-acylaminocephalosporanic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5762289A true JPS5762289A (en) | 1982-04-15 |
JPS5924159B2 JPS5924159B2 (en) | 1984-06-07 |
Family
ID=13261122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6453981A Expired JPS5924159B2 (en) | 1981-04-28 | 1981-04-28 | Method for producing 3-thiomethyl derivative of 7-acylaminocephalosporanic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5924159B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61132058U (en) * | 1985-02-07 | 1986-08-18 |
-
1981
- 1981-04-28 JP JP6453981A patent/JPS5924159B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5924159B2 (en) | 1984-06-07 |
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