JPS5762289A - Preparation of 3-thiomethyl derivative from 7-acylaminocephalosporanic acid - Google Patents

Preparation of 3-thiomethyl derivative from 7-acylaminocephalosporanic acid

Info

Publication number
JPS5762289A
JPS5762289A JP6453981A JP6453981A JPS5762289A JP S5762289 A JPS5762289 A JP S5762289A JP 6453981 A JP6453981 A JP 6453981A JP 6453981 A JP6453981 A JP 6453981A JP S5762289 A JPS5762289 A JP S5762289A
Authority
JP
Japan
Prior art keywords
formulai
compound
preparation
acid
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6453981A
Other languages
Japanese (ja)
Other versions
JPS5924159B2 (en
Inventor
Tetsuya Maeda
Masuo Murakami
Ichiro Isaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP6453981A priority Critical patent/JPS5924159B2/en
Publication of JPS5762289A publication Critical patent/JPS5762289A/en
Publication of JPS5924159B2 publication Critical patent/JPS5924159B2/en
Expired legal-status Critical Current

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  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulaI(X is imino, O or S; R is thiazolyl, triazolyl, diazolyl, etc.).
EXAMPLE: 7-[D-α-(4-Hydroxynicotinoylamido)-α-phenylacetamido]-3-(5--methyl- amino-1,3,4-thiadiazol-2-yl)thiomethyl-Δ3-cephem-4-carboxylic acid.
USE: An antimicrobial agent, effective against Gram-negative and Gram-positive bacteria, and capable of exhibiting remarkable effects particularly on Pseudomonas aeruginosa and myxomycetes.
PROCESS: A 7-acylaminocephalosporanic acid of formula II or a salt thereof is reacted with a thiol derivative of formula III or an alkaline metallic substitution product at the H of -SH group thereof to give the compound of formulaI. The reaction is preferably carried out in a solvent, e.g. acetone, under neutralWweakly alkaline conditions.
COPYRIGHT: (C)1982,JPO&Japio
JP6453981A 1981-04-28 1981-04-28 Method for producing 3-thiomethyl derivative of 7-acylaminocephalosporanic acid Expired JPS5924159B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6453981A JPS5924159B2 (en) 1981-04-28 1981-04-28 Method for producing 3-thiomethyl derivative of 7-acylaminocephalosporanic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6453981A JPS5924159B2 (en) 1981-04-28 1981-04-28 Method for producing 3-thiomethyl derivative of 7-acylaminocephalosporanic acid

Publications (2)

Publication Number Publication Date
JPS5762289A true JPS5762289A (en) 1982-04-15
JPS5924159B2 JPS5924159B2 (en) 1984-06-07

Family

ID=13261122

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6453981A Expired JPS5924159B2 (en) 1981-04-28 1981-04-28 Method for producing 3-thiomethyl derivative of 7-acylaminocephalosporanic acid

Country Status (1)

Country Link
JP (1) JPS5924159B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61132058U (en) * 1985-02-07 1986-08-18

Also Published As

Publication number Publication date
JPS5924159B2 (en) 1984-06-07

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