JPS57188575A - Preparation of 2-hydroxyquinoxaline derivative - Google Patents
Preparation of 2-hydroxyquinoxaline derivativeInfo
- Publication number
- JPS57188575A JPS57188575A JP7116381A JP7116381A JPS57188575A JP S57188575 A JPS57188575 A JP S57188575A JP 7116381 A JP7116381 A JP 7116381A JP 7116381 A JP7116381 A JP 7116381A JP S57188575 A JPS57188575 A JP S57188575A
- Authority
- JP
- Japan
- Prior art keywords
- nabh
- aqueous solution
- alkaline aqueous
- organic solvent
- compound expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled substance useful as an intermediate for medicines and agricultural chemicals, by reducing a 2-hydroxyquinoxaline-4-oxide derivative with NaBH4 in the presence of an alkaline aqueous solution in the absence of an organic solvent at a low temperature.
CONSTITUTION: A compound expressed by formulaI(X is halogen or CF3) is reduced with NaBH4 in the presence of an alkaline aqueous solution in the absence of an organic solvent at 10W30°C to give a compound expressed by formula II. NaOH in a concentration of 5W10wt% is preferred as the alkaline aqueous solution, and 0.5W1.0mol, based on one mole compound expressed by formulaI, NaBH4 to be added is enough for the reaction.
EFFECT: By-products are scarcely formed by the reduction in the presence of the alkaline aqueous solution, and the reducing reagent NaBH4 is stabilized to advance the reaction smoothly due to the uniform solution of the raw material compound. The use of water in place of the organic solvent is economical.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7116381A JPS57188575A (en) | 1981-05-12 | 1981-05-12 | Preparation of 2-hydroxyquinoxaline derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7116381A JPS57188575A (en) | 1981-05-12 | 1981-05-12 | Preparation of 2-hydroxyquinoxaline derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57188575A true JPS57188575A (en) | 1982-11-19 |
Family
ID=13452689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7116381A Pending JPS57188575A (en) | 1981-05-12 | 1981-05-12 | Preparation of 2-hydroxyquinoxaline derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57188575A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3419471A1 (en) * | 1983-05-25 | 1984-11-29 | Nippon Kayaku K.K., Tokio/Tokyo | METHOD FOR PRODUCING 2-CHINOXALINOLS |
-
1981
- 1981-05-12 JP JP7116381A patent/JPS57188575A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3419471A1 (en) * | 1983-05-25 | 1984-11-29 | Nippon Kayaku K.K., Tokio/Tokyo | METHOD FOR PRODUCING 2-CHINOXALINOLS |
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