JPS55141470A - Preparation of 3,4,5-trimethoxybenzamidopyridine - Google Patents
Preparation of 3,4,5-trimethoxybenzamidopyridineInfo
- Publication number
- JPS55141470A JPS55141470A JP4799279A JP4799279A JPS55141470A JP S55141470 A JPS55141470 A JP S55141470A JP 4799279 A JP4799279 A JP 4799279A JP 4799279 A JP4799279 A JP 4799279A JP S55141470 A JPS55141470 A JP S55141470A
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- formula
- trimethoxybenzoate
- aminopyridine
- 1mol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound, useful as an intermediate for the synthesis of high-quality medicines in high yield, without pollution, by aminolysis of an easily handleable lower alkyl 3,4,5-trimethoxybenzoate with aminopyridine.
CONSTITUTION: 1mol of a lower alkyl 3,4,5-trimethoxybenzoate of formula I (R is lower alkyl group) is reacted with 1mol of an aminopyridine of formula II (the amino group is linked to the 2-, 3-, or 4-position of the pyridine nucleus) in the presence of an equimolar amount or a small excess of a strong base, e.g. sodium methoxide, in an organic solvent, e.g. dimethylformamide or dimethyl sulfoxide, preferably at 0W100°C, to give the objective compound of formula III (-NHCO- is linked to the 2-, 3-, or 4-position of the pyridine nucleus).
USE: An intermediate for the synthesis of drugs, e.g. 3,4,5-trimethoxybenzamidopiperidine, useful as remedies for ulcers, e.g. peptic ulcer.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4799279A JPS55141470A (en) | 1979-04-20 | 1979-04-20 | Preparation of 3,4,5-trimethoxybenzamidopyridine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4799279A JPS55141470A (en) | 1979-04-20 | 1979-04-20 | Preparation of 3,4,5-trimethoxybenzamidopyridine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55141470A true JPS55141470A (en) | 1980-11-05 |
JPS6137271B2 JPS6137271B2 (en) | 1986-08-22 |
Family
ID=12790805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4799279A Granted JPS55141470A (en) | 1979-04-20 | 1979-04-20 | Preparation of 3,4,5-trimethoxybenzamidopyridine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55141470A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63162060A (en) * | 1986-12-24 | 1988-07-05 | Kitagawa Seiki Kk | Adhesive agent supply device |
-
1979
- 1979-04-20 JP JP4799279A patent/JPS55141470A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6137271B2 (en) | 1986-08-22 |
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