JPS55141470A - Preparation of 3,4,5-trimethoxybenzamidopyridine - Google Patents

Preparation of 3,4,5-trimethoxybenzamidopyridine

Info

Publication number
JPS55141470A
JPS55141470A JP4799279A JP4799279A JPS55141470A JP S55141470 A JPS55141470 A JP S55141470A JP 4799279 A JP4799279 A JP 4799279A JP 4799279 A JP4799279 A JP 4799279A JP S55141470 A JPS55141470 A JP S55141470A
Authority
JP
Japan
Prior art keywords
lower alkyl
formula
trimethoxybenzoate
aminopyridine
1mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4799279A
Other languages
Japanese (ja)
Other versions
JPS6137271B2 (en
Inventor
Hiroshi Matsukubo
Kazunori Kasuga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to JP4799279A priority Critical patent/JPS55141470A/en
Publication of JPS55141470A publication Critical patent/JPS55141470A/en
Publication of JPS6137271B2 publication Critical patent/JPS6137271B2/ja
Granted legal-status Critical Current

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  • Pyridine Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound, useful as an intermediate for the synthesis of high-quality medicines in high yield, without pollution, by aminolysis of an easily handleable lower alkyl 3,4,5-trimethoxybenzoate with aminopyridine.
CONSTITUTION: 1mol of a lower alkyl 3,4,5-trimethoxybenzoate of formula I (R is lower alkyl group) is reacted with 1mol of an aminopyridine of formula II (the amino group is linked to the 2-, 3-, or 4-position of the pyridine nucleus) in the presence of an equimolar amount or a small excess of a strong base, e.g. sodium methoxide, in an organic solvent, e.g. dimethylformamide or dimethyl sulfoxide, preferably at 0W100°C, to give the objective compound of formula III (-NHCO- is linked to the 2-, 3-, or 4-position of the pyridine nucleus).
USE: An intermediate for the synthesis of drugs, e.g. 3,4,5-trimethoxybenzamidopiperidine, useful as remedies for ulcers, e.g. peptic ulcer.
COPYRIGHT: (C)1980,JPO&Japio
JP4799279A 1979-04-20 1979-04-20 Preparation of 3,4,5-trimethoxybenzamidopyridine Granted JPS55141470A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4799279A JPS55141470A (en) 1979-04-20 1979-04-20 Preparation of 3,4,5-trimethoxybenzamidopyridine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4799279A JPS55141470A (en) 1979-04-20 1979-04-20 Preparation of 3,4,5-trimethoxybenzamidopyridine

Publications (2)

Publication Number Publication Date
JPS55141470A true JPS55141470A (en) 1980-11-05
JPS6137271B2 JPS6137271B2 (en) 1986-08-22

Family

ID=12790805

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4799279A Granted JPS55141470A (en) 1979-04-20 1979-04-20 Preparation of 3,4,5-trimethoxybenzamidopyridine

Country Status (1)

Country Link
JP (1) JPS55141470A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63162060A (en) * 1986-12-24 1988-07-05 Kitagawa Seiki Kk Adhesive agent supply device

Also Published As

Publication number Publication date
JPS6137271B2 (en) 1986-08-22

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