JPS5687565A - Production of alpha-arylpyridineacetic ester - Google Patents
Production of alpha-arylpyridineacetic esterInfo
- Publication number
- JPS5687565A JPS5687565A JP16411379A JP16411379A JPS5687565A JP S5687565 A JPS5687565 A JP S5687565A JP 16411379 A JP16411379 A JP 16411379A JP 16411379 A JP16411379 A JP 16411379A JP S5687565 A JPS5687565 A JP S5687565A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reaction
- base catalyst
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: The reaction of benzylpyridine with a carbonate ester is conducted in the presence of a strong base catalyst in a specific temperature range to produce the titled substance used as a medicine or its intermediate through one step in high yield.
CONSTITUTION: The reaction between a compound a formula I [R1, R3 are H, hydrocarbon group, halogen; R2 is H, hydrocabon group, -R4N(R5)(R6) (R4 is alkylene; R5, R6 are alkyl or bind with each other to form alkylene)] and a compound of formula II (R7, R8 are hydrocarbon group) is carried out using a strong base catalyst such as sodium hydride at 70W150°C to give the compound of formula III or IV. In the reaction, the amount of the compound of formula II is 1W10 times the molar quantity of the compound of formula I usually and the excess amount of a carbonate ester is desirably used as a solvent. The base catalyst is usually used by 1W5mol based on the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16411379A JPS5687565A (en) | 1979-12-19 | 1979-12-19 | Production of alpha-arylpyridineacetic ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16411379A JPS5687565A (en) | 1979-12-19 | 1979-12-19 | Production of alpha-arylpyridineacetic ester |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5687565A true JPS5687565A (en) | 1981-07-16 |
Family
ID=15786992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16411379A Pending JPS5687565A (en) | 1979-12-19 | 1979-12-19 | Production of alpha-arylpyridineacetic ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5687565A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997022588A1 (en) * | 1995-12-18 | 1997-06-26 | Bayer Aktiengesellschaft | Use of hetarylacetic acid derivatives as leukotriene inhibitors |
-
1979
- 1979-12-19 JP JP16411379A patent/JPS5687565A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997022588A1 (en) * | 1995-12-18 | 1997-06-26 | Bayer Aktiengesellschaft | Use of hetarylacetic acid derivatives as leukotriene inhibitors |
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