JPS5562087A - Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine - Google Patents

Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine

Info

Publication number
JPS5562087A
JPS5562087A JP13452678A JP13452678A JPS5562087A JP S5562087 A JPS5562087 A JP S5562087A JP 13452678 A JP13452678 A JP 13452678A JP 13452678 A JP13452678 A JP 13452678A JP S5562087 A JPS5562087 A JP S5562087A
Authority
JP
Japan
Prior art keywords
compound
dimethylxanthine
chloropropyl
preparation
chloropropane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13452678A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Nagatoshi Azuma
Tsuneo Uryu
Hitoshi Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP13452678A priority Critical patent/JPS5562087A/en
Publication of JPS5562087A publication Critical patent/JPS5562087A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as a synthetic intermediate of medicine for cardiovasocular diseases, easily, in high yield, by reacting 1-bromo-3-chloropropane with 3, 7-dimethylxanthine in the presence of a base.
CONSTITUTION: A compound IV is prepared by reacting 3, 7-dimethylxanthine II with 1-bromo-3-chloropropane III in a solvent such as methanol, in the presence of a base (e.g. NaOH, KOH) at 30W100°C. Reaction of the compound IV with NaI affords a more reactive compound V, which can be converted to a compound I useful as a medicine.
COPYRIGHT: (C)1980,JPO&Japio
JP13452678A 1978-11-02 1978-11-02 Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine Pending JPS5562087A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13452678A JPS5562087A (en) 1978-11-02 1978-11-02 Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13452678A JPS5562087A (en) 1978-11-02 1978-11-02 Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine

Publications (1)

Publication Number Publication Date
JPS5562087A true JPS5562087A (en) 1980-05-10

Family

ID=15130375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13452678A Pending JPS5562087A (en) 1978-11-02 1978-11-02 Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine

Country Status (1)

Country Link
JP (1) JPS5562087A (en)

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