JPS5562087A - Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine - Google Patents
Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthineInfo
- Publication number
- JPS5562087A JPS5562087A JP13452678A JP13452678A JPS5562087A JP S5562087 A JPS5562087 A JP S5562087A JP 13452678 A JP13452678 A JP 13452678A JP 13452678 A JP13452678 A JP 13452678A JP S5562087 A JPS5562087 A JP S5562087A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dimethylxanthine
- chloropropyl
- preparation
- chloropropane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound useful as a synthetic intermediate of medicine for cardiovasocular diseases, easily, in high yield, by reacting 1-bromo-3-chloropropane with 3, 7-dimethylxanthine in the presence of a base.
CONSTITUTION: A compound IV is prepared by reacting 3, 7-dimethylxanthine II with 1-bromo-3-chloropropane III in a solvent such as methanol, in the presence of a base (e.g. NaOH, KOH) at 30W100°C. Reaction of the compound IV with NaI affords a more reactive compound V, which can be converted to a compound I useful as a medicine.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13452678A JPS5562087A (en) | 1978-11-02 | 1978-11-02 | Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13452678A JPS5562087A (en) | 1978-11-02 | 1978-11-02 | Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5562087A true JPS5562087A (en) | 1980-05-10 |
Family
ID=15130375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13452678A Pending JPS5562087A (en) | 1978-11-02 | 1978-11-02 | Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5562087A (en) |
-
1978
- 1978-11-02 JP JP13452678A patent/JPS5562087A/en active Pending
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