JPS5699478A - 5-fluorouracil derivative and its preparation - Google Patents

5-fluorouracil derivative and its preparation

Info

Publication number
JPS5699478A
JPS5699478A JP244180A JP244180A JPS5699478A JP S5699478 A JPS5699478 A JP S5699478A JP 244180 A JP244180 A JP 244180A JP 244180 A JP244180 A JP 244180A JP S5699478 A JPS5699478 A JP S5699478A
Authority
JP
Japan
Prior art keywords
formula
compound
fluorouracil
preparation
molar amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP244180A
Other languages
Japanese (ja)
Inventor
Shuichi Ueda
Sanji Yasumoto
Sadao Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP244180A priority Critical patent/JPS5699478A/en
Publication of JPS5699478A publication Critical patent/JPS5699478A/en
Pending legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 5-fluorouracil derivative of formula I (R is 2W6C lower alkyl).
EXAMPLE: 1-(5'-Propionyloxy-tetrahydro-2'-furanyl)-5-fluorouracil.
USE: A carcinostatic agent or a synthetic intermediate therefor.
PROCESS: A compound of formula II is reacted with a 2,5-diacyloxytetrahydrofuran of formula III in a solvent, e.g. benzene, or under solventless conditions in the presence of a Lewis acid at a temperature of usually -30W150°C to give the compound of formula I. The molar amount of the compound of formula III is equal to or more, preferably about 1W3 times, that of the compound of formula II. The molar amount of the catalyst is preferably about 0.001W2 times that of the compound of formula II.
COPYRIGHT: (C)1981,JPO&Japio
JP244180A 1980-01-11 1980-01-11 5-fluorouracil derivative and its preparation Pending JPS5699478A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP244180A JPS5699478A (en) 1980-01-11 1980-01-11 5-fluorouracil derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP244180A JPS5699478A (en) 1980-01-11 1980-01-11 5-fluorouracil derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5699478A true JPS5699478A (en) 1981-08-10

Family

ID=11529352

Family Applications (1)

Application Number Title Priority Date Filing Date
JP244180A Pending JPS5699478A (en) 1980-01-11 1980-01-11 5-fluorouracil derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5699478A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306722A (en) * 1992-09-02 1994-04-26 Bristol-Myers Squibb Company Thymidine derivatives and therapeutic method of use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51146482A (en) * 1976-05-28 1976-12-16 Taiho Yakuhin Kogyo Kk Process for preparing n1-(2- tetrahydrofuryl)-5-fluorouracil
JPS5262285A (en) * 1975-11-13 1977-05-23 Teikoku Chem Ind Corp Ltd Preparation of n1 2'-ethoxy) furanidyl uracil derivatives
JPS52144678A (en) * 1976-05-28 1977-12-02 Hoffmann La Roche Production of uracil derivatives
JPS5459288A (en) * 1977-10-17 1979-05-12 Sanwa Kagaku Kenkyusho Co Production of n 1 *22 tetrahydrofuryl**55 fluorouracil

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5262285A (en) * 1975-11-13 1977-05-23 Teikoku Chem Ind Corp Ltd Preparation of n1 2'-ethoxy) furanidyl uracil derivatives
JPS51146482A (en) * 1976-05-28 1976-12-16 Taiho Yakuhin Kogyo Kk Process for preparing n1-(2- tetrahydrofuryl)-5-fluorouracil
JPS52144678A (en) * 1976-05-28 1977-12-02 Hoffmann La Roche Production of uracil derivatives
JPS5459288A (en) * 1977-10-17 1979-05-12 Sanwa Kagaku Kenkyusho Co Production of n 1 *22 tetrahydrofuryl**55 fluorouracil

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306722A (en) * 1992-09-02 1994-04-26 Bristol-Myers Squibb Company Thymidine derivatives and therapeutic method of use

Similar Documents

Publication Publication Date Title
JPS5576829A (en) Beta,gamma-dihydropolyprenyl alcohol and hypotensive agent made from it
JPS57171986A (en) Heterocylic ring compound containing sulfur
JPS5699478A (en) 5-fluorouracil derivative and its preparation
JPS54100367A (en) 5-phenethyl-2-oxazolidone derivative and its preparation
JPS5511503A (en) Condensed heterocyclic compound
JPS579754A (en) Preparation of methylene dicarbanilate
JPS54144320A (en) Preparation of ureidomethylene malonic ester
JPS54109974A (en) Novel imidazolecarboxylic ester derivative
JPS55111483A (en) Novel phenothiazine derivative and psychotropic drug comprising it
JPS5585568A (en) Quinolinone-imine derivative and its preparation
JPS5661365A (en) Dimethoxyphthalazinone derivative and its preparation
JPS5711957A (en) Novel aldehyde compound and its preparation
JPS56127378A (en) 2-alkoxyindolizine derivative and its preparation
JPS5527142A (en) Novel 1-phthalazone derivative
JPS5639074A (en) Pyrimidine derivative
JPS5646873A (en) 2-guanidinothiazole derivative and its preparation
JPS5668673A (en) Substituted methylidenehydrazinopyrimidine derivative and its preparation
JPS5511532A (en) Preparation of n-methyl-benzthiazolone derivative
JPS56110675A (en) N-benzoyl-n'-pyridyloxyphenylurea compound, its preparation, and insecticide containing the same
JPS5711956A (en) Novel nitro compound and its preparation
JPS5598171A (en) 5-fluorouracil derivative and its preparation
JPS55115868A (en) Beta,beta,beta-trihalo-alpha-hydroxyethyl substituted-2-aroyl pyrrole derivative
JPS54115376A (en) Preparation of 5-(4-hydroxyphenyl)-hydantoin
JPS5535045A (en) Imidazoline riboside derivative and its preparation
JPS5492955A (en) Heterocyclic compound and its preparation