JPS5699478A - 5-fluorouracil derivative and its preparation - Google Patents
5-fluorouracil derivative and its preparationInfo
- Publication number
- JPS5699478A JPS5699478A JP244180A JP244180A JPS5699478A JP S5699478 A JPS5699478 A JP S5699478A JP 244180 A JP244180 A JP 244180A JP 244180 A JP244180 A JP 244180A JP S5699478 A JPS5699478 A JP S5699478A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- fluorouracil
- preparation
- molar amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 5-fluorouracil derivative of formula I (R is 2W6C lower alkyl).
EXAMPLE: 1-(5'-Propionyloxy-tetrahydro-2'-furanyl)-5-fluorouracil.
USE: A carcinostatic agent or a synthetic intermediate therefor.
PROCESS: A compound of formula II is reacted with a 2,5-diacyloxytetrahydrofuran of formula III in a solvent, e.g. benzene, or under solventless conditions in the presence of a Lewis acid at a temperature of usually -30W150°C to give the compound of formula I. The molar amount of the compound of formula III is equal to or more, preferably about 1W3 times, that of the compound of formula II. The molar amount of the catalyst is preferably about 0.001W2 times that of the compound of formula II.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP244180A JPS5699478A (en) | 1980-01-11 | 1980-01-11 | 5-fluorouracil derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP244180A JPS5699478A (en) | 1980-01-11 | 1980-01-11 | 5-fluorouracil derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5699478A true JPS5699478A (en) | 1981-08-10 |
Family
ID=11529352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP244180A Pending JPS5699478A (en) | 1980-01-11 | 1980-01-11 | 5-fluorouracil derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5699478A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5306722A (en) * | 1992-09-02 | 1994-04-26 | Bristol-Myers Squibb Company | Thymidine derivatives and therapeutic method of use |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51146482A (en) * | 1976-05-28 | 1976-12-16 | Taiho Yakuhin Kogyo Kk | Process for preparing n1-(2- tetrahydrofuryl)-5-fluorouracil |
JPS5262285A (en) * | 1975-11-13 | 1977-05-23 | Teikoku Chem Ind Corp Ltd | Preparation of n1 2'-ethoxy) furanidyl uracil derivatives |
JPS52144678A (en) * | 1976-05-28 | 1977-12-02 | Hoffmann La Roche | Production of uracil derivatives |
JPS5459288A (en) * | 1977-10-17 | 1979-05-12 | Sanwa Kagaku Kenkyusho Co | Production of n 1 *22 tetrahydrofuryl**55 fluorouracil |
-
1980
- 1980-01-11 JP JP244180A patent/JPS5699478A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5262285A (en) * | 1975-11-13 | 1977-05-23 | Teikoku Chem Ind Corp Ltd | Preparation of n1 2'-ethoxy) furanidyl uracil derivatives |
JPS51146482A (en) * | 1976-05-28 | 1976-12-16 | Taiho Yakuhin Kogyo Kk | Process for preparing n1-(2- tetrahydrofuryl)-5-fluorouracil |
JPS52144678A (en) * | 1976-05-28 | 1977-12-02 | Hoffmann La Roche | Production of uracil derivatives |
JPS5459288A (en) * | 1977-10-17 | 1979-05-12 | Sanwa Kagaku Kenkyusho Co | Production of n 1 *22 tetrahydrofuryl**55 fluorouracil |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5306722A (en) * | 1992-09-02 | 1994-04-26 | Bristol-Myers Squibb Company | Thymidine derivatives and therapeutic method of use |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5576829A (en) | Beta,gamma-dihydropolyprenyl alcohol and hypotensive agent made from it | |
JPS57171986A (en) | Heterocylic ring compound containing sulfur | |
JPS5699478A (en) | 5-fluorouracil derivative and its preparation | |
JPS54100367A (en) | 5-phenethyl-2-oxazolidone derivative and its preparation | |
JPS5511503A (en) | Condensed heterocyclic compound | |
JPS579754A (en) | Preparation of methylene dicarbanilate | |
JPS54144320A (en) | Preparation of ureidomethylene malonic ester | |
JPS54109974A (en) | Novel imidazolecarboxylic ester derivative | |
JPS55111483A (en) | Novel phenothiazine derivative and psychotropic drug comprising it | |
JPS5585568A (en) | Quinolinone-imine derivative and its preparation | |
JPS5661365A (en) | Dimethoxyphthalazinone derivative and its preparation | |
JPS5711957A (en) | Novel aldehyde compound and its preparation | |
JPS56127378A (en) | 2-alkoxyindolizine derivative and its preparation | |
JPS5527142A (en) | Novel 1-phthalazone derivative | |
JPS5639074A (en) | Pyrimidine derivative | |
JPS5646873A (en) | 2-guanidinothiazole derivative and its preparation | |
JPS5668673A (en) | Substituted methylidenehydrazinopyrimidine derivative and its preparation | |
JPS5511532A (en) | Preparation of n-methyl-benzthiazolone derivative | |
JPS56110675A (en) | N-benzoyl-n'-pyridyloxyphenylurea compound, its preparation, and insecticide containing the same | |
JPS5711956A (en) | Novel nitro compound and its preparation | |
JPS5598171A (en) | 5-fluorouracil derivative and its preparation | |
JPS55115868A (en) | Beta,beta,beta-trihalo-alpha-hydroxyethyl substituted-2-aroyl pyrrole derivative | |
JPS54115376A (en) | Preparation of 5-(4-hydroxyphenyl)-hydantoin | |
JPS5535045A (en) | Imidazoline riboside derivative and its preparation | |
JPS5492955A (en) | Heterocyclic compound and its preparation |