JPS55115868A - Beta,beta,beta-trihalo-alpha-hydroxyethyl substituted-2-aroyl pyrrole derivative - Google Patents

Beta,beta,beta-trihalo-alpha-hydroxyethyl substituted-2-aroyl pyrrole derivative

Info

Publication number
JPS55115868A
JPS55115868A JP2253479A JP2253479A JPS55115868A JP S55115868 A JPS55115868 A JP S55115868A JP 2253479 A JP2253479 A JP 2253479A JP 2253479 A JP2253479 A JP 2253479A JP S55115868 A JPS55115868 A JP S55115868A
Authority
JP
Japan
Prior art keywords
beta
trihalo
alpha
methyl
pyrrole derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2253479A
Other languages
Japanese (ja)
Other versions
JPS5848553B2 (en
Inventor
Sei Kondo
Akira Negishi
Daiei Tsunemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP54022534A priority Critical patent/JPS5848553B2/en
Priority to IT47714/80A priority patent/IT1143924B/en
Priority to CH160080A priority patent/CH642625A5/en
Priority to SE8001554A priority patent/SE446982B/en
Publication of JPS55115868A publication Critical patent/JPS55115868A/en
Publication of JPS5848553B2 publication Critical patent/JPS5848553B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A β,β,β-trihalo-α-hydroxyethyl substituted-2-aroyl-pyrrole derivative of formula I (R is lower alkyl group; Y is H, lower alkyl or alkoxy group, or halogen; X is Cl or Br).
EXAMPLE: 1-Methyl-2-(2,2,2-trichloro-1-hydroxyethyl)-5-p-toluoylpyrrole.
USE: A precursor for preparing an anti-inflammatory agent 1-methyl-5-aroylpyrrole- acetic acid.
PROCESS: An 2-aroylpyrrole derivative of formula II, e.g. 2-benzoyl-1-methyl-pyrrole, is reacted with a trihaloacetaldehyde in the presence of an acidic catalyst to form the compound of formulaI. Alternatively, a compound of formula III is reacted with a trihalomethane in the presence of a base.
COPYRIGHT: (C)1980,JPO&Japio
JP54022534A 1979-03-01 1979-03-01 β, β, β↓-trihalo↓-α↓-hydroxyethyl-substituted↓-2↓-aroylpyrrole derivative Expired JPS5848553B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP54022534A JPS5848553B2 (en) 1979-03-01 1979-03-01 β, β, β↓-trihalo↓-α↓-hydroxyethyl-substituted↓-2↓-aroylpyrrole derivative
IT47714/80A IT1143924B (en) 1979-03-01 1980-01-25 2-AROYLPYRROL BETA, BETA-BETA-TRIALOGEN-ALPHA-HYDROXYETHYL SUBSTITUTES REPLACED
CH160080A CH642625A5 (en) 1979-03-01 1980-02-28 beta,beta,beta-Trihalo-alpha-hydroxyethyl-substituted 2-aroylpyrrole derivatives
SE8001554A SE446982B (en) 1979-03-01 1980-02-28 BETA, BETA, BETA-TRIHALOGENO-ALFA-HYDROXYETHYL-SUBSTITUTED-2-AROYLPYR ROLLER DERIVATIVES FOR USE AS INTERMEDIATE IN THE PREPARATION OF ETHIC ACID COMPOUNDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54022534A JPS5848553B2 (en) 1979-03-01 1979-03-01 β, β, β↓-trihalo↓-α↓-hydroxyethyl-substituted↓-2↓-aroylpyrrole derivative

Publications (2)

Publication Number Publication Date
JPS55115868A true JPS55115868A (en) 1980-09-06
JPS5848553B2 JPS5848553B2 (en) 1983-10-28

Family

ID=12085457

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54022534A Expired JPS5848553B2 (en) 1979-03-01 1979-03-01 β, β, β↓-trihalo↓-α↓-hydroxyethyl-substituted↓-2↓-aroylpyrrole derivative

Country Status (4)

Country Link
JP (1) JPS5848553B2 (en)
CH (1) CH642625A5 (en)
IT (1) IT1143924B (en)
SE (1) SE446982B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0783488A4 (en) * 1994-09-27 1998-01-07 Ono Pharmaceutical Co Five membered heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0783488A4 (en) * 1994-09-27 1998-01-07 Ono Pharmaceutical Co Five membered heterocyclic compounds

Also Published As

Publication number Publication date
IT8047714A0 (en) 1980-01-25
CH642625A5 (en) 1984-04-30
JPS5848553B2 (en) 1983-10-28
SE8001554L (en) 1980-09-02
IT1143924B (en) 1986-10-29
SE446982B (en) 1986-10-20

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