SE8001554L - BETA, BETA, BETA-trihalo-ALFA-hydroxyethyl-substituted-2-AROYLPYRROLDERIVAT - Google Patents

BETA, BETA, BETA-trihalo-ALFA-hydroxyethyl-substituted-2-AROYLPYRROLDERIVAT

Info

Publication number
SE8001554L
SE8001554L SE8001554A SE8001554A SE8001554L SE 8001554 L SE8001554 L SE 8001554L SE 8001554 A SE8001554 A SE 8001554A SE 8001554 A SE8001554 A SE 8001554A SE 8001554 L SE8001554 L SE 8001554L
Authority
SE
Sweden
Prior art keywords
beta
hydroxyethyl
trihalo
methyl
substituted
Prior art date
Application number
SE8001554A
Other languages
Swedish (sv)
Other versions
SE446982B (en
Inventor
K Kondo
A Negishi
D Tunemoto
Original Assignee
Sagami Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chem Res filed Critical Sagami Chem Res
Publication of SE8001554L publication Critical patent/SE8001554L/en
Publication of SE446982B publication Critical patent/SE446982B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A beta,beta,beta-trihalo-alpha-hydroxyethyl substituted-2-aroyl-pyrrole derivative of formula I (R is lower alkyl group; Y is H, lower alkyl or alkoxy group, or halogen; X is Cl or Br). EXAMPLE:1-Methyl-2-(2,2,2-trichloro-1-hydroxyethyl)-5-p-toluoylpyrrole. USE:A precursor for preparing an anti-inflammatory agent 1-methyl-5-aroylpyrrole- acetic acid. PROCESS:An 2-aroylpyrrole derivative of formula II, e.g. 2-benzoyl-1-methyl-pyrrole, is reacted with a trihaloacetaldehyde in the presence of an acidic catalyst to form the compound of formulaI. Alternatively, a compound of formula III is reacted with a trihalomethane in the presence of a base.
SE8001554A 1979-03-01 1980-02-28 BETA, BETA, BETA-TRIHALOGENO-ALFA-HYDROXYETHYL-SUBSTITUTED-2-AROYLPYR ROLLER DERIVATIVES FOR USE AS INTERMEDIATE IN THE PREPARATION OF ETHIC ACID COMPOUNDS SE446982B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54022534A JPS5848553B2 (en) 1979-03-01 1979-03-01 β, β, β↓-trihalo↓-α↓-hydroxyethyl-substituted↓-2↓-aroylpyrrole derivative

Publications (2)

Publication Number Publication Date
SE8001554L true SE8001554L (en) 1980-09-02
SE446982B SE446982B (en) 1986-10-20

Family

ID=12085457

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8001554A SE446982B (en) 1979-03-01 1980-02-28 BETA, BETA, BETA-TRIHALOGENO-ALFA-HYDROXYETHYL-SUBSTITUTED-2-AROYLPYR ROLLER DERIVATIVES FOR USE AS INTERMEDIATE IN THE PREPARATION OF ETHIC ACID COMPOUNDS

Country Status (4)

Country Link
JP (1) JPS5848553B2 (en)
CH (1) CH642625A5 (en)
IT (1) IT1143924B (en)
SE (1) SE446982B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10506892A (en) * 1994-09-27 1998-07-07 小野薬品工業株式会社 5-membered heterocyclic compounds, drugs containing them as active ingredients

Also Published As

Publication number Publication date
SE446982B (en) 1986-10-20
CH642625A5 (en) 1984-04-30
JPS55115868A (en) 1980-09-06
JPS5848553B2 (en) 1983-10-28
IT1143924B (en) 1986-10-29
IT8047714A0 (en) 1980-01-25

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