JPS54125632A - Novel salicylic acid derivative - Google Patents

Novel salicylic acid derivative

Info

Publication number
JPS54125632A
JPS54125632A JP3188378A JP3188378A JPS54125632A JP S54125632 A JPS54125632 A JP S54125632A JP 3188378 A JP3188378 A JP 3188378A JP 3188378 A JP3188378 A JP 3188378A JP S54125632 A JPS54125632 A JP S54125632A
Authority
JP
Japan
Prior art keywords
salicylic acid
formula
acid derivative
integer
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3188378A
Other languages
Japanese (ja)
Other versions
JPS6056130B2 (en
Inventor
Kanji Noda
Akira Nakagawa
Toshiharu Motomura
Masayoshi Tsuji
Hidetoshi Amano
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP3188378A priority Critical patent/JPS6056130B2/en
Publication of JPS54125632A publication Critical patent/JPS54125632A/en
Publication of JPS6056130B2 publication Critical patent/JPS6056130B2/en
Expired legal-status Critical Current

Links

Abstract

NEW MATERIAL:A salicylic acid derivative of formula I: (R is H or lower alkyl group; X is lower alkoxy group; m is an integer 1W3; n is an integer 0 or 1).
EXAMPLE: N-(3,4,5-Trimethoxybenzoyl)-5-amino salicylic acid.
USE: Medicines having an antiallergic, antipyretic, analgesic,and anti-inflammatory actions.
PROCESS: A salicylic acid derivative of formula II is reacted with a reactive derivative, e.g. an acid halide or anhydride, of a carboxylic acid of formula III in an organic solvent, e.g. tatra hydrofuran, to give the desired compound of formula I. A deacidifying agent, e.g. triethylamine, is preferably used in the case of an acid halide.
COPYRIGHT: (C)1979,JPO&Japio
JP3188378A 1978-03-20 1978-03-20 Novel salicylic acid derivatives Expired JPS6056130B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3188378A JPS6056130B2 (en) 1978-03-20 1978-03-20 Novel salicylic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3188378A JPS6056130B2 (en) 1978-03-20 1978-03-20 Novel salicylic acid derivatives

Publications (2)

Publication Number Publication Date
JPS54125632A true JPS54125632A (en) 1979-09-29
JPS6056130B2 JPS6056130B2 (en) 1985-12-09

Family

ID=12343424

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3188378A Expired JPS6056130B2 (en) 1978-03-20 1978-03-20 Novel salicylic acid derivatives

Country Status (1)

Country Link
JP (1) JPS6056130B2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003199A1 (en) * 1984-11-29 1986-06-05 Italfarmaco S.P.A. Amino-salicylic acid derivatives and pharmaceutical compositions
EP0286364A2 (en) * 1987-04-06 1988-10-12 Riker Laboratories, Inc. Substituted Di-t-Butylphenols
WO2001079153A1 (en) * 2000-04-19 2001-10-25 Neurotech Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
US6573402B1 (en) 2000-04-20 2003-06-03 Neurotech Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
US7189878B2 (en) 2002-06-19 2007-03-13 Neurotech Co., Ltd. Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same
US8455470B2 (en) 2006-04-13 2013-06-04 Neurotech Pharmaceuticals Co., Ltd Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases
US8686185B2 (en) 2007-11-12 2014-04-01 Neurotech Pharmaceuticals Co., Ltd. Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003199A1 (en) * 1984-11-29 1986-06-05 Italfarmaco S.P.A. Amino-salicylic acid derivatives and pharmaceutical compositions
EP0286364A2 (en) * 1987-04-06 1988-10-12 Riker Laboratories, Inc. Substituted Di-t-Butylphenols
WO2001079153A1 (en) * 2000-04-19 2001-10-25 Neurotech Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
US7750045B2 (en) 2000-04-20 2010-07-06 Neurotech Pharmaceuticals Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
US6964982B2 (en) 2000-04-20 2005-11-15 Neurotech Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
US6573402B1 (en) 2000-04-20 2003-06-03 Neurotech Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
US8211877B2 (en) 2000-04-20 2012-07-03 Neurotech Pharmaceuticals Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
US8211878B2 (en) 2000-04-20 2012-07-03 Neurotech Pharmaceuticals Co., Ltd. Method for reducing neuronal death in nervous system injuries resulting from amyotrophic lateral sclerosis
US7189878B2 (en) 2002-06-19 2007-03-13 Neurotech Co., Ltd. Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same
US7319160B2 (en) 2002-06-19 2008-01-15 Amkor Pharma, Inc. Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same
US7371896B2 (en) 2002-06-19 2008-05-13 Amkor Pharma, Inc. Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same
US7511074B2 (en) 2002-06-19 2009-03-31 Amkor Pharma, Inc. Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same
US8455470B2 (en) 2006-04-13 2013-06-04 Neurotech Pharmaceuticals Co., Ltd Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases
US8598383B2 (en) 2006-04-13 2013-12-03 Neurotech Pharmaceuticals Co., Ltd. Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases
US8686185B2 (en) 2007-11-12 2014-04-01 Neurotech Pharmaceuticals Co., Ltd. Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts

Also Published As

Publication number Publication date
JPS6056130B2 (en) 1985-12-09

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