JPS54125632A - Novel salicylic acid derivative - Google Patents
Novel salicylic acid derivativeInfo
- Publication number
- JPS54125632A JPS54125632A JP3188378A JP3188378A JPS54125632A JP S54125632 A JPS54125632 A JP S54125632A JP 3188378 A JP3188378 A JP 3188378A JP 3188378 A JP3188378 A JP 3188378A JP S54125632 A JPS54125632 A JP S54125632A
- Authority
- JP
- Japan
- Prior art keywords
- salicylic acid
- formula
- acid derivative
- integer
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A salicylic acid derivative of formula I: (R is H or lower alkyl group; X is lower alkoxy group; m is an integer 1W3; n is an integer 0 or 1).
EXAMPLE: N-(3,4,5-Trimethoxybenzoyl)-5-amino salicylic acid.
USE: Medicines having an antiallergic, antipyretic, analgesic,and anti-inflammatory actions.
PROCESS: A salicylic acid derivative of formula II is reacted with a reactive derivative, e.g. an acid halide or anhydride, of a carboxylic acid of formula III in an organic solvent, e.g. tatra hydrofuran, to give the desired compound of formula I. A deacidifying agent, e.g. triethylamine, is preferably used in the case of an acid halide.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3188378A JPS6056130B2 (en) | 1978-03-20 | 1978-03-20 | Novel salicylic acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3188378A JPS6056130B2 (en) | 1978-03-20 | 1978-03-20 | Novel salicylic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54125632A true JPS54125632A (en) | 1979-09-29 |
JPS6056130B2 JPS6056130B2 (en) | 1985-12-09 |
Family
ID=12343424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3188378A Expired JPS6056130B2 (en) | 1978-03-20 | 1978-03-20 | Novel salicylic acid derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6056130B2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986003199A1 (en) * | 1984-11-29 | 1986-06-05 | Italfarmaco S.P.A. | Amino-salicylic acid derivatives and pharmaceutical compositions |
EP0286364A2 (en) * | 1987-04-06 | 1988-10-12 | Riker Laboratories, Inc. | Substituted Di-t-Butylphenols |
WO2001079153A1 (en) * | 2000-04-19 | 2001-10-25 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US6573402B1 (en) | 2000-04-20 | 2003-06-03 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US7189878B2 (en) | 2002-06-19 | 2007-03-13 | Neurotech Co., Ltd. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
US8455470B2 (en) | 2006-04-13 | 2013-06-04 | Neurotech Pharmaceuticals Co., Ltd | Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases |
US8686185B2 (en) | 2007-11-12 | 2014-04-01 | Neurotech Pharmaceuticals Co., Ltd. | Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts |
-
1978
- 1978-03-20 JP JP3188378A patent/JPS6056130B2/en not_active Expired
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986003199A1 (en) * | 1984-11-29 | 1986-06-05 | Italfarmaco S.P.A. | Amino-salicylic acid derivatives and pharmaceutical compositions |
EP0286364A2 (en) * | 1987-04-06 | 1988-10-12 | Riker Laboratories, Inc. | Substituted Di-t-Butylphenols |
WO2001079153A1 (en) * | 2000-04-19 | 2001-10-25 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US7750045B2 (en) | 2000-04-20 | 2010-07-06 | Neurotech Pharmaceuticals Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US6964982B2 (en) | 2000-04-20 | 2005-11-15 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US6573402B1 (en) | 2000-04-20 | 2003-06-03 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US8211877B2 (en) | 2000-04-20 | 2012-07-03 | Neurotech Pharmaceuticals Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
US8211878B2 (en) | 2000-04-20 | 2012-07-03 | Neurotech Pharmaceuticals Co., Ltd. | Method for reducing neuronal death in nervous system injuries resulting from amyotrophic lateral sclerosis |
US7189878B2 (en) | 2002-06-19 | 2007-03-13 | Neurotech Co., Ltd. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
US7319160B2 (en) | 2002-06-19 | 2008-01-15 | Amkor Pharma, Inc. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
US7371896B2 (en) | 2002-06-19 | 2008-05-13 | Amkor Pharma, Inc. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
US7511074B2 (en) | 2002-06-19 | 2009-03-31 | Amkor Pharma, Inc. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
US8455470B2 (en) | 2006-04-13 | 2013-06-04 | Neurotech Pharmaceuticals Co., Ltd | Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases |
US8598383B2 (en) | 2006-04-13 | 2013-12-03 | Neurotech Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases |
US8686185B2 (en) | 2007-11-12 | 2014-04-01 | Neurotech Pharmaceuticals Co., Ltd. | Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts |
Also Published As
Publication number | Publication date |
---|---|
JPS6056130B2 (en) | 1985-12-09 |
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