JPS54141768A - 5-substituted indazole derivative - Google Patents
5-substituted indazole derivativeInfo
- Publication number
- JPS54141768A JPS54141768A JP4924778A JP4924778A JPS54141768A JP S54141768 A JPS54141768 A JP S54141768A JP 4924778 A JP4924778 A JP 4924778A JP 4924778 A JP4924778 A JP 4924778A JP S54141768 A JPS54141768 A JP S54141768A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- och
- group
- indazole derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 5-substituted indazole derivative of formula I: [R1 is H, CH3, or OCH3; X is O or two groups R2 and R3 (R2 is H or CH3; R3 is OH, CH3, or OCH3 group)].
EXAMPLE: 4,5,6,7-Tetrahydro-1-phenylindazole-5-carboxylic methyl ester.
USE: Safe medicines having improved anti-inflammatory, analgesic, and antipyretic actions with slight toxicity and side effects.
PROCESS: A compound of formula II is esterified with diazomethane to give the objective compound of formula I wherein R1 is OCH3 and X is O. The ester group is selectively reduced to form the desired compound of formula I wherein R1 and R2 are hydrogens and R3 is OH group. The compound thus obtained in then oxidized, methylated, oxidized, and methylated twice to give the objective compound of formula I wherein R1 and X are different.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4924778A JPS54141768A (en) | 1978-04-27 | 1978-04-27 | 5-substituted indazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4924778A JPS54141768A (en) | 1978-04-27 | 1978-04-27 | 5-substituted indazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54141768A true JPS54141768A (en) | 1979-11-05 |
Family
ID=12825517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4924778A Pending JPS54141768A (en) | 1978-04-27 | 1978-04-27 | 5-substituted indazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54141768A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006138373A2 (en) | 2005-06-14 | 2006-12-28 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF |
-
1978
- 1978-04-27 JP JP4924778A patent/JPS54141768A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006138373A2 (en) | 2005-06-14 | 2006-12-28 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF |
WO2006138373A3 (en) * | 2005-06-14 | 2007-05-10 | Bristol Myers Squibb Co | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF |
JP2008546702A (en) * | 2005-06-14 | 2008-12-25 | ブリストル−マイヤーズ スクイブ カンパニー | Glucocorticoid receptor, AP-1, and / or modulator of NF-κB activity, and use thereof |
US7888381B2 (en) | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
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