JPS54141768A - 5-substituted indazole derivative - Google Patents

5-substituted indazole derivative

Info

Publication number
JPS54141768A
JPS54141768A JP4924778A JP4924778A JPS54141768A JP S54141768 A JPS54141768 A JP S54141768A JP 4924778 A JP4924778 A JP 4924778A JP 4924778 A JP4924778 A JP 4924778A JP S54141768 A JPS54141768 A JP S54141768A
Authority
JP
Japan
Prior art keywords
formula
compound
och
group
indazole derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4924778A
Other languages
Japanese (ja)
Inventor
Takeo Oba
Tatsuyuki Naritomo
Hitoshi Omori
Seiji Kurozumi
Toshio Wakabayashi
Toshio Tanaka
Kenzo Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP4924778A priority Critical patent/JPS54141768A/en
Publication of JPS54141768A publication Critical patent/JPS54141768A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 5-substituted indazole derivative of formula I: [R1 is H, CH3, or OCH3; X is O or two groups R2 and R3 (R2 is H or CH3; R3 is OH, CH3, or OCH3 group)].
EXAMPLE: 4,5,6,7-Tetrahydro-1-phenylindazole-5-carboxylic methyl ester.
USE: Safe medicines having improved anti-inflammatory, analgesic, and antipyretic actions with slight toxicity and side effects.
PROCESS: A compound of formula II is esterified with diazomethane to give the objective compound of formula I wherein R1 is OCH3 and X is O. The ester group is selectively reduced to form the desired compound of formula I wherein R1 and R2 are hydrogens and R3 is OH group. The compound thus obtained in then oxidized, methylated, oxidized, and methylated twice to give the objective compound of formula I wherein R1 and X are different.
COPYRIGHT: (C)1979,JPO&Japio
JP4924778A 1978-04-27 1978-04-27 5-substituted indazole derivative Pending JPS54141768A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4924778A JPS54141768A (en) 1978-04-27 1978-04-27 5-substituted indazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4924778A JPS54141768A (en) 1978-04-27 1978-04-27 5-substituted indazole derivative

Publications (1)

Publication Number Publication Date
JPS54141768A true JPS54141768A (en) 1979-11-05

Family

ID=12825517

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4924778A Pending JPS54141768A (en) 1978-04-27 1978-04-27 5-substituted indazole derivative

Country Status (1)

Country Link
JP (1) JPS54141768A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138373A2 (en) 2005-06-14 2006-12-28 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138373A2 (en) 2005-06-14 2006-12-28 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
WO2006138373A3 (en) * 2005-06-14 2007-05-10 Bristol Myers Squibb Co MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
JP2008546702A (en) * 2005-06-14 2008-12-25 ブリストル−マイヤーズ スクイブ カンパニー Glucocorticoid receptor, AP-1, and / or modulator of NF-κB activity, and use thereof
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof

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