JPS56113794A - Carcinostatic agent and its preparation - Google Patents
Carcinostatic agent and its preparationInfo
- Publication number
- JPS56113794A JPS56113794A JP1469980A JP1469980A JPS56113794A JP S56113794 A JPS56113794 A JP S56113794A JP 1469980 A JP1469980 A JP 1469980A JP 1469980 A JP1469980 A JP 1469980A JP S56113794 A JPS56113794 A JP S56113794A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- squalene
- compound
- thymidinephenoxyacetate
- phenoxyacetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A thymidine derivative of squalene expressed by formula IVa (R is COCH2Oϕ) or formula IVb (R is H).
EXAMPLE: Squalene ester of thymidine-phenoxyacetate.
USE: A carcinostatic agent having improved carcinostatic effect and preventing effect on metastasis of cancer with low toxicity, and administrable continuously.
PROCESS: A thymidinephenoxyacetate trityl ether of formula I is treated with a weak acid to give a thymidinephenoxyacetate of formula II. The compound of formula II or III is esterified by a diethyl azodicarboxylate and triphenylphosphine to afford the compound of formula IVa. The weak hydrolysis of the compound provides an ester of squalene-ω-carboxylic acid expressed by formula IVb in which the phenoxyacetate is removed.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1469980A JPS5846520B2 (en) | 1980-02-12 | 1980-02-12 | Thymidine derivative of squalene and its production method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1469980A JPS5846520B2 (en) | 1980-02-12 | 1980-02-12 | Thymidine derivative of squalene and its production method |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56113794A true JPS56113794A (en) | 1981-09-07 |
JPS5846520B2 JPS5846520B2 (en) | 1983-10-17 |
Family
ID=11868426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1469980A Expired JPS5846520B2 (en) | 1980-02-12 | 1980-02-12 | Thymidine derivative of squalene and its production method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5846520B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6919437B1 (en) * | 1998-06-11 | 2005-07-19 | Isis Pharmaceuticals, Inc. | Synthetic methods and intermediates for triester oligonucleotides |
-
1980
- 1980-02-12 JP JP1469980A patent/JPS5846520B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6919437B1 (en) * | 1998-06-11 | 2005-07-19 | Isis Pharmaceuticals, Inc. | Synthetic methods and intermediates for triester oligonucleotides |
Also Published As
Publication number | Publication date |
---|---|
JPS5846520B2 (en) | 1983-10-17 |
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