JPS5618936A - Production of phenylacetic acid - Google Patents
Production of phenylacetic acidInfo
- Publication number
- JPS5618936A JPS5618936A JP9525579A JP9525579A JPS5618936A JP S5618936 A JPS5618936 A JP S5618936A JP 9525579 A JP9525579 A JP 9525579A JP 9525579 A JP9525579 A JP 9525579A JP S5618936 A JPS5618936 A JP S5618936A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- phenylacetic acid
- formula
- dehalogenation
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: The dehalogenation of a halogenated substituted phenylacetic acid gives a phenylacetic acid used as a modifier for antibiotics or synthetic intermediate for anti-inflammatory analgesic in high yield with industrial advantage from the view point of the price of the starting materials as well.
CONSTITUTION: The catalytic hydrogenolysis of halogenated substituted phenylacetic acid of formula I (X is halogen; R1, R2 are H, lower alkyl; R3 is H, lower alkyl, hydroxyl), preferable 3-chloro-4-hydroxy-phenylacetic acid, is conducted in a solvent mainly consisting of water, lower alcohol or their mixture in the presence of a strong acid such as sulfuric acid to cause the dehalogenation and form a phenylacetic acid of formula II, preferably 4-hydroxyphenylacetic acid. Since the compound of formula I is readily derived through mandelic acid derivative from glyoxylic acid and o-chlorophenol, the present process is superior to existing processes from view point of the costs of the starting material as well.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9525579A JPS5618936A (en) | 1979-07-25 | 1979-07-25 | Production of phenylacetic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9525579A JPS5618936A (en) | 1979-07-25 | 1979-07-25 | Production of phenylacetic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5618936A true JPS5618936A (en) | 1981-02-23 |
| JPS63421B2 JPS63421B2 (en) | 1988-01-07 |
Family
ID=14132644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9525579A Granted JPS5618936A (en) | 1979-07-25 | 1979-07-25 | Production of phenylacetic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5618936A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973736A (en) * | 1981-12-28 | 1990-11-27 | Basf Aktiengesellschaft | Diethers of m- or p-hydroxyphenol |
| FR2686877A1 (en) * | 1992-01-31 | 1993-08-06 | Hoechst France | Process for the preparation of ortho-hydroxyphenylacetic acid |
| JPH09134118A (en) * | 1995-11-10 | 1997-05-20 | Ritsutai Shiyashinzou Kk | Production of relief photograph image |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54125635A (en) * | 1978-02-20 | 1979-09-29 | Diamalt Ag | Manufacture of 44hydroxyphenylacetic acid |
-
1979
- 1979-07-25 JP JP9525579A patent/JPS5618936A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54125635A (en) * | 1978-02-20 | 1979-09-29 | Diamalt Ag | Manufacture of 44hydroxyphenylacetic acid |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973736A (en) * | 1981-12-28 | 1990-11-27 | Basf Aktiengesellschaft | Diethers of m- or p-hydroxyphenol |
| FR2686877A1 (en) * | 1992-01-31 | 1993-08-06 | Hoechst France | Process for the preparation of ortho-hydroxyphenylacetic acid |
| US5768643A (en) * | 1995-10-11 | 1998-06-16 | Rittaishashinzo Co., Ltd. | Method of producing photographic relief |
| JPH09134118A (en) * | 1995-11-10 | 1997-05-20 | Ritsutai Shiyashinzou Kk | Production of relief photograph image |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63421B2 (en) | 1988-01-07 |
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