JPS5515451A - Preparation of 4-cyanocyclohexanecarboxylic acids - Google Patents

Preparation of 4-cyanocyclohexanecarboxylic acids

Info

Publication number
JPS5515451A
JPS5515451A JP8862378A JP8862378A JPS5515451A JP S5515451 A JPS5515451 A JP S5515451A JP 8862378 A JP8862378 A JP 8862378A JP 8862378 A JP8862378 A JP 8862378A JP S5515451 A JPS5515451 A JP S5515451A
Authority
JP
Japan
Prior art keywords
esp
alcohol
imidated
cyanocyclohexanecarboxylic
dicyanocyclohexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8862378A
Other languages
Japanese (ja)
Other versions
JPS6141347B2 (en
Inventor
Tadamitsu Hirayama
Shinji Kanbara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP8862378A priority Critical patent/JPS5515451A/en
Publication of JPS5515451A publication Critical patent/JPS5515451A/en
Publication of JPS6141347B2 publication Critical patent/JPS6141347B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as an intermediate of anti-plasmic agents, etc., in high yield, by reacting 1,4-dicyanocyclohexane with an alcohol and a mineral acid under specific conditions, and then hydrolyzing the resulting partially imidated compound.
CONSTITUTION: One of the two cyano groups of 1,4-dicyanocyclohexane is imidated by reacting with a specific amount of a lower primary alcohol (esp. methanol) and an excess amount of a mineral acid (esp. HC1), in a specific solvent such as an aromatic hydrocarbon (benzene, toluene, etc.) and halogenated hydrocarbon (ethylenedichloride, etc.) at 0W50°C. The molar ratio of the alcohol to the cyclohexane derivative is 1.0W2.0, esp. pref. 1.2W1.5. Hydrolysis of the partially imidated compound with water, etc. affords 4-cyanocyclohexanecarboxylic acid or its ester.
COPYRIGHT: (C)1980,JPO&Japio
JP8862378A 1978-07-20 1978-07-20 Preparation of 4-cyanocyclohexanecarboxylic acids Granted JPS5515451A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8862378A JPS5515451A (en) 1978-07-20 1978-07-20 Preparation of 4-cyanocyclohexanecarboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8862378A JPS5515451A (en) 1978-07-20 1978-07-20 Preparation of 4-cyanocyclohexanecarboxylic acids

Publications (2)

Publication Number Publication Date
JPS5515451A true JPS5515451A (en) 1980-02-02
JPS6141347B2 JPS6141347B2 (en) 1986-09-13

Family

ID=13947926

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8862378A Granted JPS5515451A (en) 1978-07-20 1978-07-20 Preparation of 4-cyanocyclohexanecarboxylic acids

Country Status (1)

Country Link
JP (1) JPS5515451A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5114506A (en) * 1974-07-26 1976-02-05 Hitachi Ltd DORENBUNRISOCHI

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5114506A (en) * 1974-07-26 1976-02-05 Hitachi Ltd DORENBUNRISOCHI

Also Published As

Publication number Publication date
JPS6141347B2 (en) 1986-09-13

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