JPS5515451A - Preparation of 4-cyanocyclohexanecarboxylic acids - Google Patents
Preparation of 4-cyanocyclohexanecarboxylic acidsInfo
- Publication number
- JPS5515451A JPS5515451A JP8862378A JP8862378A JPS5515451A JP S5515451 A JPS5515451 A JP S5515451A JP 8862378 A JP8862378 A JP 8862378A JP 8862378 A JP8862378 A JP 8862378A JP S5515451 A JPS5515451 A JP S5515451A
- Authority
- JP
- Japan
- Prior art keywords
- esp
- alcohol
- imidated
- cyanocyclohexanecarboxylic
- dicyanocyclohexane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the title compound useful as an intermediate of anti-plasmic agents, etc., in high yield, by reacting 1,4-dicyanocyclohexane with an alcohol and a mineral acid under specific conditions, and then hydrolyzing the resulting partially imidated compound.
CONSTITUTION: One of the two cyano groups of 1,4-dicyanocyclohexane is imidated by reacting with a specific amount of a lower primary alcohol (esp. methanol) and an excess amount of a mineral acid (esp. HC1), in a specific solvent such as an aromatic hydrocarbon (benzene, toluene, etc.) and halogenated hydrocarbon (ethylenedichloride, etc.) at 0W50°C. The molar ratio of the alcohol to the cyclohexane derivative is 1.0W2.0, esp. pref. 1.2W1.5. Hydrolysis of the partially imidated compound with water, etc. affords 4-cyanocyclohexanecarboxylic acid or its ester.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8862378A JPS5515451A (en) | 1978-07-20 | 1978-07-20 | Preparation of 4-cyanocyclohexanecarboxylic acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8862378A JPS5515451A (en) | 1978-07-20 | 1978-07-20 | Preparation of 4-cyanocyclohexanecarboxylic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5515451A true JPS5515451A (en) | 1980-02-02 |
JPS6141347B2 JPS6141347B2 (en) | 1986-09-13 |
Family
ID=13947926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8862378A Granted JPS5515451A (en) | 1978-07-20 | 1978-07-20 | Preparation of 4-cyanocyclohexanecarboxylic acids |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5515451A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5114506A (en) * | 1974-07-26 | 1976-02-05 | Hitachi Ltd | DORENBUNRISOCHI |
-
1978
- 1978-07-20 JP JP8862378A patent/JPS5515451A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5114506A (en) * | 1974-07-26 | 1976-02-05 | Hitachi Ltd | DORENBUNRISOCHI |
Also Published As
Publication number | Publication date |
---|---|
JPS6141347B2 (en) | 1986-09-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS54119494A (en) | Preparation of cephalosporin compound | |
JPS5515451A (en) | Preparation of 4-cyanocyclohexanecarboxylic acids | |
IE45593L (en) | Phenylglyoxylic acid compounds | |
JPS54151985A (en) | Preparation of aminocarbostyril derivative | |
JPS53108933A (en) | Production of amidinoformic acid derivative | |
JPS5618936A (en) | Production of phenylacetic acid | |
JPS5798232A (en) | 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal | |
JPS6446A (en) | Production of 4-hydroxy-2-cyclopentenone derivative | |
JPS54112892A (en) | Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid | |
JPS54128567A (en) | 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative | |
JPS557832A (en) | Preparation of fibrous zr-containing phosphoric acid compound | |
JPS5528953A (en) | Racemization of optically active alpha-substituted arylacetic acid | |
KR890009841A (en) | Preparation of ester | |
JPS5536450A (en) | Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate | |
JPS5535066A (en) | Novel pyrazole derivative | |
JPS55120591A (en) | Phosphinoethylmalonic acid derivative, and preparation thereof | |
JPS5640638A (en) | Preparation of pyruvic acid | |
JPS5569535A (en) | Preparation of dihydro-coenzyme q analog compound | |
JPS5587770A (en) | Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester | |
JPS54138575A (en) | Preparation of isoquinoline alcohols | |
JPS55118452A (en) | Production of alpha-cyanopropionic ester derivative | |
JPS5545604A (en) | Nitro compound | |
JPS5721339A (en) | Esterification of organic carboxylic acid | |
JPS559028A (en) | Novel 3'-(alpha-hydroxybenzyl)-propiophenone and its preparation | |
JPS53105467A (en) | Preparation of phenyletheralcohol derivative acrylates or methacylates |