JPS5536450A - Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate - Google Patents

Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate

Info

Publication number
JPS5536450A
JPS5536450A JP11046778A JP11046778A JPS5536450A JP S5536450 A JPS5536450 A JP S5536450A JP 11046778 A JP11046778 A JP 11046778A JP 11046778 A JP11046778 A JP 11046778A JP S5536450 A JPS5536450 A JP S5536450A
Authority
JP
Japan
Prior art keywords
formula
benzoylphenyl
propionic acid
oxidizing agent
strong
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11046778A
Other languages
Japanese (ja)
Inventor
Tamio Ueyama
Sueo Horiuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamari Chemicals Ltd
Original Assignee
Hamari Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamari Chemicals Ltd filed Critical Hamari Chemicals Ltd
Priority to JP11046778A priority Critical patent/JPS5536450A/en
Publication of JPS5536450A publication Critical patent/JPS5536450A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound useful as an antiplogistic and analgesic in high yield, by hydrolyzing a condenszate of easily available 3-benzyl acetophenone with an α-halogeno-acetate, by decarboxylating the hydrohyzate, and by oxidizing the resulting product with a strong oxidizing agent.
CONSTITUTION: 3-Benzylacetophenone is condensed with an α-halogenoacetate under the conditions of Darzen's condensation to give a glycidate of formula I: (-COOR is esterified carboxyl group), which is hydrolyzed in the presence of an alkali, and decarboxylated in the presence of a strong acid, e.g. HCl, to form novel 2-(3-benzylphenyl)-propionaldehyde of formula II. The methylene and aldehyde groups of the aldehyde are oxidized with a strong oxidizing agent, e.g. a permanganate, to afford 2-(3-benzoylphenyl)-propionic acid of formula III.
COPYRIGHT: (C)1980,JPO&Japio
JP11046778A 1978-09-07 1978-09-07 Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate Pending JPS5536450A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11046778A JPS5536450A (en) 1978-09-07 1978-09-07 Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11046778A JPS5536450A (en) 1978-09-07 1978-09-07 Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate

Publications (1)

Publication Number Publication Date
JPS5536450A true JPS5536450A (en) 1980-03-14

Family

ID=14536439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11046778A Pending JPS5536450A (en) 1978-09-07 1978-09-07 Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate

Country Status (1)

Country Link
JP (1) JPS5536450A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6179527A (en) * 1984-09-27 1986-04-23 Fujitsu Ltd Line work system
JPS63230652A (en) * 1987-03-20 1988-09-27 Nippon Petrochem Co Ltd Production of alpha-(3-benzoylphenyl)propionic acid
US4999450A (en) * 1987-03-20 1991-03-12 Nippon Petrochemicals Company, Limited Process for preparing alpha-(3-benzylphenyl) propionic acid derivative

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116636A (en) * 1974-07-29 1976-02-10 Nisshin Flour Milling Co 22 * chikanariiru * puropionsanno seiho
JPS5165730A (en) * 1974-12-03 1976-06-07 Fujikawa Kk FUENIRUARUKANKARUBONSANJUDOTAINO SEIHO

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116636A (en) * 1974-07-29 1976-02-10 Nisshin Flour Milling Co 22 * chikanariiru * puropionsanno seiho
JPS5165730A (en) * 1974-12-03 1976-06-07 Fujikawa Kk FUENIRUARUKANKARUBONSANJUDOTAINO SEIHO

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6179527A (en) * 1984-09-27 1986-04-23 Fujitsu Ltd Line work system
JPH0364259B2 (en) * 1984-09-27 1991-10-04 Fujitsu Ltd
JPS63230652A (en) * 1987-03-20 1988-09-27 Nippon Petrochem Co Ltd Production of alpha-(3-benzoylphenyl)propionic acid
US4999450A (en) * 1987-03-20 1991-03-12 Nippon Petrochemicals Company, Limited Process for preparing alpha-(3-benzylphenyl) propionic acid derivative

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