JPS5536450A - Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate - Google Patents
Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediateInfo
- Publication number
- JPS5536450A JPS5536450A JP11046778A JP11046778A JPS5536450A JP S5536450 A JPS5536450 A JP S5536450A JP 11046778 A JP11046778 A JP 11046778A JP 11046778 A JP11046778 A JP 11046778A JP S5536450 A JPS5536450 A JP S5536450A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- benzoylphenyl
- propionic acid
- oxidizing agent
- strong
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound useful as an antiplogistic and analgesic in high yield, by hydrolyzing a condenszate of easily available 3-benzyl acetophenone with an α-halogeno-acetate, by decarboxylating the hydrohyzate, and by oxidizing the resulting product with a strong oxidizing agent.
CONSTITUTION: 3-Benzylacetophenone is condensed with an α-halogenoacetate under the conditions of Darzen's condensation to give a glycidate of formula I: (-COOR is esterified carboxyl group), which is hydrolyzed in the presence of an alkali, and decarboxylated in the presence of a strong acid, e.g. HCl, to form novel 2-(3-benzylphenyl)-propionaldehyde of formula II. The methylene and aldehyde groups of the aldehyde are oxidized with a strong oxidizing agent, e.g. a permanganate, to afford 2-(3-benzoylphenyl)-propionic acid of formula III.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11046778A JPS5536450A (en) | 1978-09-07 | 1978-09-07 | Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11046778A JPS5536450A (en) | 1978-09-07 | 1978-09-07 | Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5536450A true JPS5536450A (en) | 1980-03-14 |
Family
ID=14536439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11046778A Pending JPS5536450A (en) | 1978-09-07 | 1978-09-07 | Preparation of 2-(3-benzoylphenyl)-propionic acid and its intermediate |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5536450A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6179527A (en) * | 1984-09-27 | 1986-04-23 | Fujitsu Ltd | Line work system |
JPS63230652A (en) * | 1987-03-20 | 1988-09-27 | Nippon Petrochem Co Ltd | Production of alpha-(3-benzoylphenyl)propionic acid |
US4999450A (en) * | 1987-03-20 | 1991-03-12 | Nippon Petrochemicals Company, Limited | Process for preparing alpha-(3-benzylphenyl) propionic acid derivative |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5116636A (en) * | 1974-07-29 | 1976-02-10 | Nisshin Flour Milling Co | 22 * chikanariiru * puropionsanno seiho |
JPS5165730A (en) * | 1974-12-03 | 1976-06-07 | Fujikawa Kk | FUENIRUARUKANKARUBONSANJUDOTAINO SEIHO |
-
1978
- 1978-09-07 JP JP11046778A patent/JPS5536450A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5116636A (en) * | 1974-07-29 | 1976-02-10 | Nisshin Flour Milling Co | 22 * chikanariiru * puropionsanno seiho |
JPS5165730A (en) * | 1974-12-03 | 1976-06-07 | Fujikawa Kk | FUENIRUARUKANKARUBONSANJUDOTAINO SEIHO |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6179527A (en) * | 1984-09-27 | 1986-04-23 | Fujitsu Ltd | Line work system |
JPH0364259B2 (en) * | 1984-09-27 | 1991-10-04 | Fujitsu Ltd | |
JPS63230652A (en) * | 1987-03-20 | 1988-09-27 | Nippon Petrochem Co Ltd | Production of alpha-(3-benzoylphenyl)propionic acid |
US4999450A (en) * | 1987-03-20 | 1991-03-12 | Nippon Petrochemicals Company, Limited | Process for preparing alpha-(3-benzylphenyl) propionic acid derivative |
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