JPS55154932A - Preparation of 3-benzoylbenzaldehyde by oxidation - Google Patents
Preparation of 3-benzoylbenzaldehyde by oxidationInfo
- Publication number
- JPS55154932A JPS55154932A JP6160079A JP6160079A JPS55154932A JP S55154932 A JPS55154932 A JP S55154932A JP 6160079 A JP6160079 A JP 6160079A JP 6160079 A JP6160079 A JP 6160079A JP S55154932 A JPS55154932 A JP S55154932A
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- benzoylbenzaldehyde
- oxidation
- acid anhydride
- methylbenzophenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound, useful as the starting material of ketoprofen having antiinflammatory and analgesic activities, in high yield, by the oxidation of 3-methylbenzophenone in the presence of a lower fatty acid anhydride, followed by hydrolysis.
CONSTITUTION: 3-Methylbenzophenone is oxidized with an oxidizing agent, e.g. CrO3, in the presence of a lower fatty acid anhydride, preferably acetic anhydride, and preferably in the presence of an acid catalyst, e.g. H2SO4, to give 3-benzoylbenzaldehydediacylacetal, which is then hydrolyzed to afford 3-benzoylbenzaldehyde of the formula. The reaction temp. is in the range of -10W+50°C and the reaction period is 1W5hr when acetic anhydride is used as the fatty acid anhydride, H2SO4 as the acid catalyst, and CrO3 as the oxidizing agent.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6160079A JPS55154932A (en) | 1979-05-21 | 1979-05-21 | Preparation of 3-benzoylbenzaldehyde by oxidation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6160079A JPS55154932A (en) | 1979-05-21 | 1979-05-21 | Preparation of 3-benzoylbenzaldehyde by oxidation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55154932A true JPS55154932A (en) | 1980-12-02 |
Family
ID=13175806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6160079A Pending JPS55154932A (en) | 1979-05-21 | 1979-05-21 | Preparation of 3-benzoylbenzaldehyde by oxidation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55154932A (en) |
-
1979
- 1979-05-21 JP JP6160079A patent/JPS55154932A/en active Pending
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