IE41999L - PREPARATION OF 6, 11-DIHYDRO-11-OXODIBENZ [b,e]¹OXEPIN-ALKANOIC ACIDS. - Google Patents
PREPARATION OF 6, 11-DIHYDRO-11-OXODIBENZ [b,e]¹OXEPIN-ALKANOIC ACIDS.Info
- Publication number
- IE41999L IE41999L IE760054A IE5476A IE41999L IE 41999 L IE41999 L IE 41999L IE 760054 A IE760054 A IE 760054A IE 5476 A IE5476 A IE 5476A IE 41999 L IE41999 L IE 41999L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- oxodibenz
- dihydro
- compounds
- 1oxepin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
6,11-Dihydro-11-oxodibenz[b,e]oxepinealkanoic acids of the formula I are prepared from dicarbonyl halides of the formula II which are converted into oxepinealkanoyl halides which are then hydrolysed to compounds of the formula I. The symbols in the formulae have the meaning stated in Claim 1. The reaction is carried out either with a Lewis acid in the presence of solvents at 0 DEG C to room temperature or in the presence of iron chloride without solvent at temperatures from 100 to 150 DEG C. The compounds of the formula II can be prepared by treating the corresponding dicarboxylic acid with a mixture of thionyl chloride and iron chloride at room temperature to the boiling point of the reaction mixture. The compounds of the formula I have anti-inflammatory and analgesic effects. <IMAGE>
[GB1538775A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54096375A | 1975-01-14 | 1975-01-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41999L true IE41999L (en) | 1976-07-14 |
| IE41999B1 IE41999B1 (en) | 1980-05-07 |
Family
ID=24157637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE54/76A IE41999B1 (en) | 1975-01-14 | 1976-01-13 | Preparation of 6,11-dihydro-11-oxodiben(b,e)-oxepin-alkanoic acids |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS5195085A (en) |
| AT (1) | AT362376B (en) |
| BE (1) | BE837561A (en) |
| CA (1) | CA1081240A (en) |
| CH (1) | CH627464A5 (en) |
| CS (2) | CS190550B2 (en) |
| DK (1) | DK12376A (en) |
| ES (1) | ES444144A1 (en) |
| FI (1) | FI760052A (en) |
| FR (1) | FR2297852A1 (en) |
| GB (1) | GB1538775A (en) |
| HU (1) | HU175610B (en) |
| IE (1) | IE41999B1 (en) |
| IT (1) | IT1054782B (en) |
| LU (1) | LU74174A1 (en) |
| MX (1) | MX3745E (en) |
| NL (1) | NL7600204A (en) |
| NO (2) | NO149387C (en) |
| PT (1) | PT64691B (en) |
| SE (1) | SE422796B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56156273A (en) * | 1980-03-31 | 1981-12-02 | Dainippon Pharmaceut Co Ltd | Acetic derivative |
| US4576960A (en) * | 1981-12-23 | 1986-03-18 | Hoechst Roussel Pharmaceuticals Incorporated | 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives |
| US4515946A (en) * | 1981-12-23 | 1985-05-07 | Hoechst-Roussel Pharmaceuticals Inc. | 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives |
| US4526891A (en) * | 1983-03-10 | 1985-07-02 | Hoechst Roussel Pharmaceuticals Inc. | Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins |
| EP1487776A4 (en) * | 2002-03-27 | 2005-05-25 | Smithkline Beecham Corp | Acid and ester compounds and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1279682B (en) * | 1961-08-12 | 1968-10-10 | Boehringer & Soehne Gmbh | Process for the preparation of 6, 11-dihydro-dibenzo- [b, e] -oxepin- or -thiepin-11-one |
| DE1294970B (en) * | 1961-09-28 | 1969-05-14 | Boehringer & Soehne Gmbh | Process for the preparation of substituted 6, 11-dihydrodibenzo [b, e] -oxepin- or -thiepin-11-ones |
| FR1449569A (en) * | 1961-10-07 | 1966-05-06 | Boehringer & Soehne Gmbh | Process for the preparation of basic derivatives of dibenzo-oxepin and dibenzo-thiepin, their salts and their quaternary ammonium compounds |
| YU204274A (en) * | 1973-07-24 | 1982-06-30 | Hoechst Ag | Process for preparing new dibenzoxepin derivatives |
-
1976
- 1976-01-08 ES ES444144A patent/ES444144A1/en not_active Expired
- 1976-01-09 NL NL7600204A patent/NL7600204A/en not_active Application Discontinuation
- 1976-01-12 FI FI760052A patent/FI760052A/fi not_active Application Discontinuation
- 1976-01-12 IT IT19179/76A patent/IT1054782B/en active
- 1976-01-13 CS CS777409A patent/CS190550B2/en unknown
- 1976-01-13 GB GB1181/76A patent/GB1538775A/en not_active Expired
- 1976-01-13 DK DK12376*#A patent/DK12376A/en not_active Application Discontinuation
- 1976-01-13 CS CS76222A patent/CS190509B2/en unknown
- 1976-01-13 CH CH33876A patent/CH627464A5/en not_active IP Right Cessation
- 1976-01-13 IE IE54/76A patent/IE41999B1/en unknown
- 1976-01-13 NO NO760101A patent/NO149387C/en unknown
- 1976-01-13 HU HU76HO1871A patent/HU175610B/en unknown
- 1976-01-13 CA CA243,400A patent/CA1081240A/en not_active Expired
- 1976-01-13 AT AT17476A patent/AT362376B/en not_active IP Right Cessation
- 1976-01-13 LU LU74174A patent/LU74174A1/xx unknown
- 1976-01-13 PT PT64691A patent/PT64691B/en unknown
- 1976-01-14 FR FR7600784A patent/FR2297852A1/en active Granted
- 1976-01-14 JP JP51003719A patent/JPS5195085A/en active Pending
- 1976-01-14 SE SE7600321A patent/SE422796B/en unknown
- 1976-01-14 MX MX762392U patent/MX3745E/en unknown
- 1976-01-14 BE BE163509A patent/BE837561A/en not_active IP Right Cessation
-
1981
- 1981-04-24 NO NO811390A patent/NO150157C/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5195085A (en) | 1976-08-20 |
| NO760101L (en) | 1976-07-15 |
| DK12376A (en) | 1976-07-15 |
| NO150157B (en) | 1984-05-21 |
| PT64691A (en) | 1976-05-01 |
| AT362376B (en) | 1981-05-11 |
| IE41999B1 (en) | 1980-05-07 |
| LU74174A1 (en) | 1976-12-31 |
| NO149387C (en) | 1984-04-11 |
| IT1054782B (en) | 1981-11-30 |
| HU175610B (en) | 1980-09-28 |
| NO150157C (en) | 1984-08-29 |
| SE422796B (en) | 1982-03-29 |
| NO811390L (en) | 1976-07-15 |
| CA1081240A (en) | 1980-07-08 |
| MX3745E (en) | 1981-06-11 |
| FR2297852A1 (en) | 1976-08-13 |
| NO149387B (en) | 1984-01-02 |
| NL7600204A (en) | 1976-07-16 |
| ATA17476A (en) | 1980-10-15 |
| ES444144A1 (en) | 1977-08-16 |
| PT64691B (en) | 1977-08-09 |
| GB1538775A (en) | 1979-01-24 |
| CS190550B2 (en) | 1979-05-31 |
| FI760052A (en) | 1976-07-15 |
| BE837561A (en) | 1976-07-14 |
| SE7600321L (en) | 1976-07-15 |
| CS190509B2 (en) | 1979-05-31 |
| CH627464A5 (en) | 1982-01-15 |
| FR2297852B1 (en) | 1979-08-31 |
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