JPS559002A - 5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the same - Google Patents
5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the sameInfo
- Publication number
- JPS559002A JPS559002A JP8048578A JP8048578A JPS559002A JP S559002 A JPS559002 A JP S559002A JP 8048578 A JP8048578 A JP 8048578A JP 8048578 A JP8048578 A JP 8048578A JP S559002 A JPS559002 A JP S559002A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- picolinic acid
- formula
- preparation
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:5-Substituted picolinic acid ester and amide of formula I [R1= C2-6 lower alkyl containing Cl, Br, I or F, substituted phenyl of formula II (R3, R4=H, halogen, lower alkyl, lower alkoxy, nitro, amino, etc.); R2=C1-5 lower alkoxy, aminoalkoxy, phenoxy, substituted phenoxy, 5-indanyloxy, etc.
EXAMPLE: 5-(4-Chlorobutoxy)-picolinic acid indanyl ester.
USE: Hypotensive agent having low toxicity and useful for the treatment of hypertension.
PROCESS: A compound of formula I is obtained by the reaction of, e.g. 5-substituted picolinic acid of formula III (M=H, metallic atom) or its salt with C1-5 aliphatic alcohol, phenol, substituted phenol, 5-indanol, or amino of formula IV (R7, R8=H, lower alkyl, etc.) in the presence of an acidic catalyst or a condensation agent.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8048578A JPS559002A (en) | 1978-07-04 | 1978-07-04 | 5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the same |
CA323,912A CA1115709A (en) | 1978-03-24 | 1979-03-21 | 5-substituted-hydroxy picolinic acid derivatives |
IT48451/79A IT1115064B (en) | 1978-03-24 | 1979-03-22 | 5-SUBSTITUTED PICOLINIC ACID DERIVATIVES PROCEDURE FOR PREPARING THEM AND HYPERTENSIVE COMPOSITIONS CONTAINING THEM |
CH268779A CH637941A5 (en) | 1978-03-24 | 1979-03-22 | DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN POSITION 5 AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES. |
NLAANVRAGE7902306,A NL178251C (en) | 1978-03-24 | 1979-03-23 | 5-SUBSTITUTED PICOLIC ACIDS AND THEIR DERIVATIVES, ANTI-BLOOD EFFECTS, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM. |
ES478918A ES478918A1 (en) | 1978-03-24 | 1979-03-23 | 5-Substituted picolinic acid derivatives, a process for preparation thereof and an anti-hypertensive composition containing the same |
SE7902665A SE446863B (en) | 1978-03-24 | 1979-03-23 | 5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PROCEDURE FOR PREPARING THEREOF AND USING THE COMPOUNDS AS ACTIVE INGREDIENT IN AN ANTI-HYPERTENSIVE COMPOSITION |
GB7910324A GB2018753B (en) | 1978-03-24 | 1979-03-23 | 5-substituted picolinic acid derivatives a process for preparation thereof and ananti-hypertensive composition containing the same |
US06/023,504 US4229448A (en) | 1978-03-24 | 1979-03-23 | 5-Substituted picolinic acid derivatives and an anti-hypertensive composition containing the same |
DE2911492A DE2911492C2 (en) | 1978-03-24 | 1979-03-23 | 5-Substituted picolinic acids, their sodium, potassium, magnesium, calcium and aluminum salts, 5-indanyl esters and acid amides, processes for their preparation and antihypertensive agents containing them |
FR7907345A FR2422639A1 (en) | 1978-03-24 | 1979-03-23 | DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8048578A JPS559002A (en) | 1978-07-04 | 1978-07-04 | 5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS559002A true JPS559002A (en) | 1980-01-22 |
JPS6134424B2 JPS6134424B2 (en) | 1986-08-07 |
Family
ID=13719580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8048578A Granted JPS559002A (en) | 1978-03-24 | 1978-07-04 | 5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS559002A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0448499Y2 (en) * | 1985-12-19 | 1992-11-16 | ||
JPS62176723U (en) * | 1986-04-28 | 1987-11-10 | ||
JPH0515061Y2 (en) * | 1986-05-09 | 1993-04-21 | ||
JPS6373628U (en) * | 1986-10-31 | 1988-05-17 |
-
1978
- 1978-07-04 JP JP8048578A patent/JPS559002A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6134424B2 (en) | 1986-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR840003247A (en) | Process for preparing ascorbic acid ether and related compounds | |
CA2011087A1 (en) | Use of trifluoromethylphenylazolylmethyloxiranes as crop protection agents | |
JPS559002A (en) | 5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the same | |
JPS57118555A (en) | Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component | |
JPS57131771A (en) | Novel pyrimidine derivative | |
JPS5576803A (en) | Agent for controlling noxious life | |
SE8200309L (en) | GUANIDINOCYKLOHEXANKARBOXYLSYRADERIVAT | |
JPS5754177A (en) | Substituted thiazole derivative | |
JPS5764683A (en) | 2-(substituted phenyl)-5-alkylthiazolidin-4-one and remedy for pepticulcer containing said compound as active component | |
JPS5740479A (en) | Preparation of benzofuran derivative and its acid addition salt | |
JPS5645454A (en) | Cyclohexanecarboxylic acid derivative and its preparation | |
JPS5770878A (en) | Isoxazole compound | |
JPS57206644A (en) | Preparation of 4-(4- (anilino)phenoxy)-2-pentenoic acid derivative | |
JPS5511503A (en) | Condensed heterocyclic compound | |
JPS5287129A (en) | 4-trifluoromethyl phenoxy phenoxyankane carboxylic acid | |
JPS57154183A (en) | Omega-piperazinylalkanoylalkylene dioxybenzenes and their acid addition salts | |
JPS5551068A (en) | Novel hydantoin derivative, and antiphlogistic analgesic agent containing the same | |
JPS55104254A (en) | N-substituted-alpha-cyano-3-phenoxybenzylamine | |
JPS57212172A (en) | Preparation of cyanuric halide derivative | |
JPS5780379A (en) | (omega-piperazinylalkoxy)alkylenedioxybenzene and its acid addition salt | |
JPS54135763A (en) | Azetidinone derivative having substituted amino group, its salt, and their preparation | |
JPS5690070A (en) | Novel pyrimidine derivative | |
JPS57200397A (en) | Novel aldohexopyranose-, aldopentopyranose-, or and medicament composition comprising it aldopentofuranose- nitrosourea compound, its preparation | |
JPS5436257A (en) | Substituted benzoic acid amide | |
JPS52113979A (en) | Novel 3,4-dihydrocarbostyril derivatives and method preparing the same |