FR2422639A1 - DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES - Google Patents

DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES

Info

Publication number
FR2422639A1
FR2422639A1 FR7907345A FR7907345A FR2422639A1 FR 2422639 A1 FR2422639 A1 FR 2422639A1 FR 7907345 A FR7907345 A FR 7907345A FR 7907345 A FR7907345 A FR 7907345A FR 2422639 A1 FR2422639 A1 FR 2422639A1
Authority
FR
France
Prior art keywords
derivatives
preparation
composition containing
picolinic acid
acid substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7907345A
Other languages
French (fr)
Other versions
FR2422639B1 (en
Inventor
Yasuharu Sekizawa
Takashi Tsuruoka
Mitsugu Hachisu
Masaji Sezaki
Masashi Miyamoto
Uichi Shibata
Kazuko Mizutani
Shigeharu Inouye
Takemi Koeda
Keizo Shimomura
Taro Niida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3296778A external-priority patent/JPS54125681A/en
Priority claimed from JP3296678A external-priority patent/JPS54125680A/en
Priority claimed from JP8048578A external-priority patent/JPS559002A/en
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Publication of FR2422639A1 publication Critical patent/FR2422639A1/en
Application granted granted Critical
Publication of FR2422639B1 publication Critical patent/FR2422639B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention se rapporte à des acides picoliniques substitués en 5, nouveaux et utiles, et à leurs sels, à des esters picoliniques substitués en 5 et à des amides d'acides picoliniques substitués en 5, à un procédé permettant leur préparation ainsi qu'à des compositions pharmaceutiques contenant ces substances. Les acides picoliniques substitués sont représentés par la formule (I) :The invention relates to novel and useful 5-substituted picolinic acids and their salts, 5-substituted picolinic esters and 5-substituted picolinic acid amides, to a process for their preparation, and to to pharmaceutical compositions containing these substances. Substituted picolinic acids are represented by formula (I):

FR7907345A 1978-03-24 1979-03-23 DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES Granted FR2422639A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3296778A JPS54125681A (en) 1978-03-24 1978-03-24 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same
JP3296678A JPS54125680A (en) 1978-03-24 1978-03-24 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same
JP8048578A JPS559002A (en) 1978-07-04 1978-07-04 5-substituted picolinic acid derivative, its preparation and hypotensive agent containing the same

Publications (2)

Publication Number Publication Date
FR2422639A1 true FR2422639A1 (en) 1979-11-09
FR2422639B1 FR2422639B1 (en) 1983-05-20

Family

ID=27287919

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7907345A Granted FR2422639A1 (en) 1978-03-24 1979-03-23 DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES

Country Status (9)

Country Link
CA (1) CA1115709A (en)
CH (1) CH637941A5 (en)
DE (1) DE2911492C2 (en)
ES (1) ES478918A1 (en)
FR (1) FR2422639A1 (en)
GB (1) GB2018753B (en)
IT (1) IT1115064B (en)
NL (1) NL178251C (en)
SE (1) SE446863B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344572A (en) * 1976-09-30 1978-04-21 Meiji Seika Kaisha Ltd 5-alkoxy-picolic acid, its preparation and hypotensives containing the same

Also Published As

Publication number Publication date
CA1115709A (en) 1982-01-05
SE7902665L (en) 1979-09-25
CH637941A5 (en) 1983-08-31
DE2911492C2 (en) 1983-05-05
FR2422639B1 (en) 1983-05-20
IT7948451A0 (en) 1979-03-22
DE2911492A1 (en) 1979-09-27
NL178251B (en) 1985-09-16
GB2018753A (en) 1979-10-24
GB2018753B (en) 1982-08-25
SE446863B (en) 1986-10-13
NL178251C (en) 1986-02-17
NL7902306A (en) 1979-09-26
ES478918A1 (en) 1979-12-16
IT1115064B (en) 1986-02-03

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Legal Events

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ST Notification of lapse