JPS54125681A - 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same - Google Patents

5-substituted picolinic acid, its preparation, and hypotensive agent containing the same

Info

Publication number
JPS54125681A
JPS54125681A JP3296778A JP3296778A JPS54125681A JP S54125681 A JPS54125681 A JP S54125681A JP 3296778 A JP3296778 A JP 3296778A JP 3296778 A JP3296778 A JP 3296778A JP S54125681 A JPS54125681 A JP S54125681A
Authority
JP
Japan
Prior art keywords
halogen
picolinic acid
compound
hypotensive agent
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3296778A
Other languages
Japanese (ja)
Other versions
JPS6134423B2 (en
Inventor
Taiji Sekizawa
Takashi Tsuruoka
Mitsugi Hachisu
Masaji Sezaki
Masashi Miyamoto
Uichi Shibata
Kazuko Mizutani
Shigeharu Inoue
Takemi Koeda
Keizo Shimomura
Taro Niida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP3296778A priority Critical patent/JPS54125681A/en
Priority to CA323,912A priority patent/CA1115709A/en
Priority to IT48451/79A priority patent/IT1115064B/en
Priority to CH268779A priority patent/CH637941A5/en
Priority to US06/023,504 priority patent/US4229448A/en
Priority to SE7902665A priority patent/SE446863B/en
Priority to ES478918A priority patent/ES478918A1/en
Priority to GB7910324A priority patent/GB2018753B/en
Priority to DE2911492A priority patent/DE2911492C2/en
Priority to FR7907345A priority patent/FR2422639A1/en
Priority to NLAANVRAGE7902306,A priority patent/NL178251C/en
Publication of JPS54125681A publication Critical patent/JPS54125681A/en
Publication of JPS6134423B2 publication Critical patent/JPS6134423B2/ja
Granted legal-status Critical Current

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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:5-Substituted picolinic acid and its salt of formula I [R1 is halogen-containing 2-6C alkyl, substituted phenyl II (R2,3 are H, halogen, lower alkyl, etc.); M is H, Na, K, Ca, A1, etc.].
EXAMPLE: 5-(4-Chlorobutoxy)-picolinic acid.
USE: Long-acting hypotensive agent for oral administration.
PROCESS: A compound I wherein R1 is R5 (R5 is halogen-containing 2W6C alkyl) is prepared by (1) reacting a compound III (R4 is methyl, hydroxymethyl) with a halogen compound R5X (X is halogen) in an organic solvent such as DMF, dimethylsulfoxide, etc., in the presence of a base such as KOH, triethylamine, etc. at 30W100°C, and (2) oxidizing the resulted compound IV with KMnO4, nitric acid, etc., in a solvent such as acetone, dioxane, etc.
COPYRIGHT: (C)1979,JPO&Japio
JP3296778A 1978-03-24 1978-03-24 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same Granted JPS54125681A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP3296778A JPS54125681A (en) 1978-03-24 1978-03-24 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same
CA323,912A CA1115709A (en) 1978-03-24 1979-03-21 5-substituted-hydroxy picolinic acid derivatives
IT48451/79A IT1115064B (en) 1978-03-24 1979-03-22 5-SUBSTITUTED PICOLINIC ACID DERIVATIVES PROCEDURE FOR PREPARING THEM AND HYPERTENSIVE COMPOSITIONS CONTAINING THEM
CH268779A CH637941A5 (en) 1978-03-24 1979-03-22 DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN POSITION 5 AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES.
US06/023,504 US4229448A (en) 1978-03-24 1979-03-23 5-Substituted picolinic acid derivatives and an anti-hypertensive composition containing the same
SE7902665A SE446863B (en) 1978-03-24 1979-03-23 5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PROCEDURE FOR PREPARING THEREOF AND USING THE COMPOUNDS AS ACTIVE INGREDIENT IN AN ANTI-HYPERTENSIVE COMPOSITION
ES478918A ES478918A1 (en) 1978-03-24 1979-03-23 5-Substituted picolinic acid derivatives, a process for preparation thereof and an anti-hypertensive composition containing the same
GB7910324A GB2018753B (en) 1978-03-24 1979-03-23 5-substituted picolinic acid derivatives a process for preparation thereof and ananti-hypertensive composition containing the same
DE2911492A DE2911492C2 (en) 1978-03-24 1979-03-23 5-Substituted picolinic acids, their sodium, potassium, magnesium, calcium and aluminum salts, 5-indanyl esters and acid amides, processes for their preparation and antihypertensive agents containing them
FR7907345A FR2422639A1 (en) 1978-03-24 1979-03-23 DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES
NLAANVRAGE7902306,A NL178251C (en) 1978-03-24 1979-03-23 5-SUBSTITUTED PICOLIC ACIDS AND THEIR DERIVATIVES, ANTI-BLOOD EFFECTS, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3296778A JPS54125681A (en) 1978-03-24 1978-03-24 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same

Publications (2)

Publication Number Publication Date
JPS54125681A true JPS54125681A (en) 1979-09-29
JPS6134423B2 JPS6134423B2 (en) 1986-08-07

Family

ID=12373671

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3296778A Granted JPS54125681A (en) 1978-03-24 1978-03-24 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same

Country Status (1)

Country Link
JP (1) JPS54125681A (en)

Also Published As

Publication number Publication date
JPS6134423B2 (en) 1986-08-07

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