JPS54125681A - 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same - Google Patents
5-substituted picolinic acid, its preparation, and hypotensive agent containing the sameInfo
- Publication number
- JPS54125681A JPS54125681A JP3296778A JP3296778A JPS54125681A JP S54125681 A JPS54125681 A JP S54125681A JP 3296778 A JP3296778 A JP 3296778A JP 3296778 A JP3296778 A JP 3296778A JP S54125681 A JPS54125681 A JP S54125681A
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- picolinic acid
- compound
- hypotensive agent
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:5-Substituted picolinic acid and its salt of formula I [R1 is halogen-containing 2-6C alkyl, substituted phenyl II (R2,3 are H, halogen, lower alkyl, etc.); M is H, Na, K, Ca, A1, etc.].
EXAMPLE: 5-(4-Chlorobutoxy)-picolinic acid.
USE: Long-acting hypotensive agent for oral administration.
PROCESS: A compound I wherein R1 is R5 (R5 is halogen-containing 2W6C alkyl) is prepared by (1) reacting a compound III (R4 is methyl, hydroxymethyl) with a halogen compound R5X (X is halogen) in an organic solvent such as DMF, dimethylsulfoxide, etc., in the presence of a base such as KOH, triethylamine, etc. at 30W100°C, and (2) oxidizing the resulted compound IV with KMnO4, nitric acid, etc., in a solvent such as acetone, dioxane, etc.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3296778A JPS54125681A (en) | 1978-03-24 | 1978-03-24 | 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same |
CA323,912A CA1115709A (en) | 1978-03-24 | 1979-03-21 | 5-substituted-hydroxy picolinic acid derivatives |
IT48451/79A IT1115064B (en) | 1978-03-24 | 1979-03-22 | 5-SUBSTITUTED PICOLINIC ACID DERIVATIVES PROCEDURE FOR PREPARING THEM AND HYPERTENSIVE COMPOSITIONS CONTAINING THEM |
CH268779A CH637941A5 (en) | 1978-03-24 | 1979-03-22 | DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN POSITION 5 AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES. |
US06/023,504 US4229448A (en) | 1978-03-24 | 1979-03-23 | 5-Substituted picolinic acid derivatives and an anti-hypertensive composition containing the same |
SE7902665A SE446863B (en) | 1978-03-24 | 1979-03-23 | 5-SUBSTITUTED PICOLIC ACID DERIVATIVES, PROCEDURE FOR PREPARING THEREOF AND USING THE COMPOUNDS AS ACTIVE INGREDIENT IN AN ANTI-HYPERTENSIVE COMPOSITION |
ES478918A ES478918A1 (en) | 1978-03-24 | 1979-03-23 | 5-Substituted picolinic acid derivatives, a process for preparation thereof and an anti-hypertensive composition containing the same |
GB7910324A GB2018753B (en) | 1978-03-24 | 1979-03-23 | 5-substituted picolinic acid derivatives a process for preparation thereof and ananti-hypertensive composition containing the same |
DE2911492A DE2911492C2 (en) | 1978-03-24 | 1979-03-23 | 5-Substituted picolinic acids, their sodium, potassium, magnesium, calcium and aluminum salts, 5-indanyl esters and acid amides, processes for their preparation and antihypertensive agents containing them |
FR7907345A FR2422639A1 (en) | 1978-03-24 | 1979-03-23 | DERIVATIVES OF PICOLINIC ACID SUBSTITUTED IN 5, PROCESS OF PREPARATION AND ANTI-HYPERTENSIVE COMPOSITION CONTAINING THESE DERIVATIVES |
NLAANVRAGE7902306,A NL178251C (en) | 1978-03-24 | 1979-03-23 | 5-SUBSTITUTED PICOLIC ACIDS AND THEIR DERIVATIVES, ANTI-BLOOD EFFECTS, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3296778A JPS54125681A (en) | 1978-03-24 | 1978-03-24 | 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54125681A true JPS54125681A (en) | 1979-09-29 |
JPS6134423B2 JPS6134423B2 (en) | 1986-08-07 |
Family
ID=12373671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3296778A Granted JPS54125681A (en) | 1978-03-24 | 1978-03-24 | 5-substituted picolinic acid, its preparation, and hypotensive agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54125681A (en) |
-
1978
- 1978-03-24 JP JP3296778A patent/JPS54125681A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6134423B2 (en) | 1986-08-07 |
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