JPS54154763A - Thiazolidine derivative - Google Patents
Thiazolidine derivativeInfo
- Publication number
- JPS54154763A JPS54154763A JP6289478A JP6289478A JPS54154763A JP S54154763 A JPS54154763 A JP S54154763A JP 6289478 A JP6289478 A JP 6289478A JP 6289478 A JP6289478 A JP 6289478A JP S54154763 A JPS54154763 A JP S54154763A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- reacted
- lower alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A thiazolidine derivative of formula I: (R1 is lower alkanoyl, alkoxycarbonyl, or N-alkyl-thiocarbamoyl group; R2 is H or CH3 group).
EXAMPLE: 3-[3-Acetylthio-2(S)-methylpropionyl]-4(R)-thiazolidinecarboxylic acid.
USE: Medicines, e.g. remedies for hypertension, having hypotensive actions.
PROCESS: A reactive derivative, e.g. an acid chloride, of a compound of formula II is reacted with a 4(R)-thiazolidinecarboxylic acid of formula III usually in the presence of an deacidification agent, e.g. triethylamine, in an inert solvent, e.g. methylene chloride, to give the objective compound of formula I. Alternatively, the compound of formula III is reacted with a compound of formula IV: (X is halogen; R1 is lower alkanoyl or alkoxycarbonyl group) or a compound of formula V: (R3 is a alkyl group).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6289478A JPS54154763A (en) | 1978-05-25 | 1978-05-25 | Thiazolidine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6289478A JPS54154763A (en) | 1978-05-25 | 1978-05-25 | Thiazolidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54154763A true JPS54154763A (en) | 1979-12-06 |
Family
ID=13213401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6289478A Pending JPS54154763A (en) | 1978-05-25 | 1978-05-25 | Thiazolidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54154763A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981002893A1 (en) * | 1980-04-02 | 1981-10-15 | Santen Pharmaceutical Co Ltd | Sulfur-containing acylamino acids |
-
1978
- 1978-05-25 JP JP6289478A patent/JPS54154763A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981002893A1 (en) * | 1980-04-02 | 1981-10-15 | Santen Pharmaceutical Co Ltd | Sulfur-containing acylamino acids |
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