JPS5585585A - Novel piperidine derivative and hypotensor containing the same - Google Patents

Novel piperidine derivative and hypotensor containing the same

Info

Publication number
JPS5585585A
JPS5585585A JP15868978A JP15868978A JPS5585585A JP S5585585 A JPS5585585 A JP S5585585A JP 15868978 A JP15868978 A JP 15868978A JP 15868978 A JP15868978 A JP 15868978A JP S5585585 A JPS5585585 A JP S5585585A
Authority
JP
Japan
Prior art keywords
formula
compound
group
same
hypotensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15868978A
Other languages
Japanese (ja)
Other versions
JPS623151B2 (en
Inventor
Yoshihiro Nakamizo
Hiroyuki Obase
Kazuhiro Kubo
Yutaka Kasuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP15868978A priority Critical patent/JPS5585585A/en
Publication of JPS5585585A publication Critical patent/JPS5585585A/en
Publication of JPS623151B2 publication Critical patent/JPS623151B2/ja
Granted legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Piperidine derivatives of formula I (Q is group of formula II or III; R is H, methyl) or their acid adduct salts. EXAMPLE:1-[2-oxo-2-(3,4,5-Trimethoxyphenyl)-1-ethyl]-4-(2-keto-1-benzi midazolinyl)-piperidine. USE:Hypotensor. PREPARATION:The reaction between a compound of formula IV (X is halogen, OSO2CH3, etc.) and another compound of formula V is carried out in the presence of a base as triethylamine in an inert solvent as chloroform, dichloromethane at 0- 80 deg.C to form the compound of formula I wherein Q is the group of formula II. The product is treated with sodium in an inert solvent as methanol to effect the metal reduction to given the compound of formula I wherein Q is the group of formula III.
JP15868978A 1978-12-25 1978-12-25 Novel piperidine derivative and hypotensor containing the same Granted JPS5585585A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15868978A JPS5585585A (en) 1978-12-25 1978-12-25 Novel piperidine derivative and hypotensor containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15868978A JPS5585585A (en) 1978-12-25 1978-12-25 Novel piperidine derivative and hypotensor containing the same

Publications (2)

Publication Number Publication Date
JPS5585585A true JPS5585585A (en) 1980-06-27
JPS623151B2 JPS623151B2 (en) 1987-01-23

Family

ID=15677194

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15868978A Granted JPS5585585A (en) 1978-12-25 1978-12-25 Novel piperidine derivative and hypotensor containing the same

Country Status (1)

Country Link
JP (1) JPS5585585A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5668680A (en) * 1979-11-06 1981-06-09 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and hypotensive agent containing the same
KR100494448B1 (en) * 1996-06-04 2005-12-02 화브리까 에스파놀라 데 프로둑또스 뀌미꼬스 이 화르마세우띠꼬스 쏘시에떼 아노님 Novel benzoimidazole derivatives with antihistamine activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5059473A (en) * 1973-09-25 1975-05-22
JPS50145644A (en) * 1974-05-13 1975-11-22
JPS5210388A (en) * 1975-07-15 1977-01-26 Sekisui Jushi Co Ltd Multi-layer vinyl fluoride resin coating

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5756474B2 (en) * 1973-05-26 1982-11-30
JPS51125239A (en) * 1975-03-05 1976-11-01 Sumitomo Chem Co Ltd Process for preparing new bytyrophenone derivatives
JPS5227775A (en) * 1975-08-28 1977-03-02 Sumitomo Chem Co Ltd Preparation of novel acylhydrazone derivatives and their salts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5059473A (en) * 1973-09-25 1975-05-22
JPS50145644A (en) * 1974-05-13 1975-11-22
JPS5210388A (en) * 1975-07-15 1977-01-26 Sekisui Jushi Co Ltd Multi-layer vinyl fluoride resin coating

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5668680A (en) * 1979-11-06 1981-06-09 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and hypotensive agent containing the same
KR100494448B1 (en) * 1996-06-04 2005-12-02 화브리까 에스파놀라 데 프로둑또스 뀌미꼬스 이 화르마세우띠꼬스 쏘시에떼 아노님 Novel benzoimidazole derivatives with antihistamine activity

Also Published As

Publication number Publication date
JPS623151B2 (en) 1987-01-23

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