JPS57193449A - Novel tin 2-nitrothiophenol complex compound, its preparation and preparation of threo substituted- propionic acid derivative with the same - Google Patents

Novel tin 2-nitrothiophenol complex compound, its preparation and preparation of threo substituted- propionic acid derivative with the same

Info

Publication number
JPS57193449A
JPS57193449A JP56078317A JP7831781A JPS57193449A JP S57193449 A JPS57193449 A JP S57193449A JP 56078317 A JP56078317 A JP 56078317A JP 7831781 A JP7831781 A JP 7831781A JP S57193449 A JPS57193449 A JP S57193449A
Authority
JP
Japan
Prior art keywords
preparation
compound
threo
substituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56078317A
Other languages
Japanese (ja)
Other versions
JPS6351148B2 (en
Inventor
Hirozumi Inoue
Tomiki Hashiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP56078317A priority Critical patent/JPS57193449A/en
Priority to EP82100807A priority patent/EP0059335B1/en
Priority to AT82100807T priority patent/ATE13292T1/en
Priority to DE8282100807T priority patent/DE3263466D1/en
Priority to US06/346,922 priority patent/US4420628A/en
Priority to CA000396154A priority patent/CA1175855A/en
Priority to FI820598A priority patent/FI76556C/en
Priority to DK082682A priority patent/DK170159B1/en
Priority to SU823396151A priority patent/SU1149873A3/en
Priority to BG055565A priority patent/BG40650A3/en
Priority to HU82601A priority patent/HU187655B/en
Priority to ES509973A priority patent/ES509973A0/en
Priority to KR8200877A priority patent/KR900000520B1/en
Publication of JPS57193449A publication Critical patent/JPS57193449A/en
Publication of JPS6351148B2 publication Critical patent/JPS6351148B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain a threo substituted-propionic acid derivative which is a synthetic intermediate for anti Ca2+ coronary circulatory enchancers, etc. in high yield in a short time, by reacting a novel tin 2-nitrothiophenol complex compound with a specific glycidic ester.
CONSTITUTION: A compound of formula II is reacted with a compound of formula III (X is halogen or aliphatic acyloxy ; y is 4 or 2) to give a novel compound of formulaI(x is 0, 1 or 2). The reaction is carried out in a solvent, e.g. benzene, at -30W+60°C. The resultant compound is then reacted with a trans-3- (4-methoxyphenyl)glycidic ester of formula IV (R is ester residue) to give a threo substituted -propionic acid derivative of formula V. The reaction is carried out in a solvent, e.g. benzene, at 0W60°C usually within 10min. The resultant compound of formula V is useful as a synthetic interemediate for diltiazem hydrochloride.
COPYRIGHT: (C)1982,JPO&Japio
JP56078317A 1981-02-27 1981-05-22 Novel tin 2-nitrothiophenol complex compound, its preparation and preparation of threo substituted- propionic acid derivative with the same Granted JPS57193449A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP56078317A JPS57193449A (en) 1981-05-22 1981-05-22 Novel tin 2-nitrothiophenol complex compound, its preparation and preparation of threo substituted- propionic acid derivative with the same
EP82100807A EP0059335B1 (en) 1981-02-27 1982-02-04 Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
AT82100807T ATE13292T1 (en) 1981-02-27 1982-02-04 PROCESS FOR THE PREPARATION OF THREO-2-HYDROXY-3-(-METHOXYPHENYL)-3-(2-NITROPH NYLTHIO)-PROPIONIC ACID ESTERS.
DE8282100807T DE3263466D1 (en) 1981-02-27 1982-02-04 Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
US06/346,922 US4420628A (en) 1981-02-27 1982-02-08 Process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
CA000396154A CA1175855A (en) 1981-02-27 1982-02-12 Process for preparing threo-2-hydroxy-3-(4- methoxyphenyl)-3-(2-nitrophenylthio) propionic ester
FI820598A FI76556C (en) 1981-02-27 1982-02-23 FOERFARANDE FOER FRAMSTAELLANDE AV TREO-2- HYDROXI-3- (4-METHOXIFENYL) -3- (2-NITROPHENYLTIO) -PROPIONSYREESTER.
DK082682A DK170159B1 (en) 1981-02-27 1982-02-25 Process for the preparation of a threo-2-hydroxy-3- (4-methoxyphenyl) -3- (2-nitrophenylthio) propionic acid ester
SU823396151A SU1149873A3 (en) 1981-02-27 1982-02-25 Method of obtaining threo-2-oxy-(4-methoxyphenyl)-3-(2-nitrophenylthio) propione ester and its version
BG055565A BG40650A3 (en) 1981-02-27 1982-02-26 Method for preparing ester of treo- 2- hydroxy- 3- (4- metoxyphenyl)- 3- (2- nitrophenylthio)- propionic acid
HU82601A HU187655B (en) 1981-02-27 1982-02-26 Process for preparing threo-2-hydroxy-3-/4-methoxy-phenyl/-3-/2-nitro-phenyl-thio/-propionic acid ester derivatives
ES509973A ES509973A0 (en) 1981-02-27 1982-02-26 A PROCEDURE FOR THE PREPARATION OF A TREO-2-HYDROXY-3- (4-METOXIPHENYL) -3- (2-NITROPHENYLTIO) PROPIONIC ESTER.
KR8200877A KR900000520B1 (en) 1981-02-27 1982-02-27 Process for preparing threo-2-hydroxy-3-(4-methoxy-phenyl)-3-(2-nitrophenylthio)-propionic ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56078317A JPS57193449A (en) 1981-05-22 1981-05-22 Novel tin 2-nitrothiophenol complex compound, its preparation and preparation of threo substituted- propionic acid derivative with the same

Publications (2)

Publication Number Publication Date
JPS57193449A true JPS57193449A (en) 1982-11-27
JPS6351148B2 JPS6351148B2 (en) 1988-10-13

Family

ID=13658556

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56078317A Granted JPS57193449A (en) 1981-02-27 1981-05-22 Novel tin 2-nitrothiophenol complex compound, its preparation and preparation of threo substituted- propionic acid derivative with the same

Country Status (1)

Country Link
JP (1) JPS57193449A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08145045A (en) * 1993-09-08 1996-06-04 Nippon Baldwin Kk Cooling roller device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08145045A (en) * 1993-09-08 1996-06-04 Nippon Baldwin Kk Cooling roller device

Also Published As

Publication number Publication date
JPS6351148B2 (en) 1988-10-13

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